PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Ahy011400
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Dalbergieae; Arachis
Family HSF
Protein Properties Length: 349aa    MW: 40245.9 Da    PI: 8.5686
Description HSF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
gnl|UG|Ahy#S59553122PU_refUnigeneView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HSF_DNA-bind116.41.7e-361382292102
                   HHHHHHHHHCTGGGTTTSEESSSSSEEEES-HHHHHHHTHHHHSTT--HHHHHHHHHHTTEEE---SSBTTTTXTTSEEEEESXXXXXXXXXXXXXX CS
  HSF_DNA-bind   2 FlkklyeiledeelkeliswsengnsfvvldeeefakkvLpkyFkhsnfaSFvRQLnmYgFkkvkdeekkskskekiweFkhksFkkgkkellekik 98 
                   Fl+k+ye+++d+e++ ++swsen +sf+v++++efak +LpkyFkhsnf+SF+RQLn+YgF+kv++++         weF+++ F+ gkk+ll++i+
     Ahy011400 138 FLRKTYEMVDDPETDPIVSWSENRDSFIVWESHEFAKVLLPKYFKHSNFSSFIRQLNTYGFRKVDSDR---------WEFANEGFQGGKKHLLKNIR 225
                   9****************************************************************999.........******************** PP

                   XXXX CS
  HSF_DNA-bind  99 rkks 102
                   r+++
     Ahy011400 226 RRSK 229
                   **87 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM004154.7E-60134227IPR000232Heat shock factor (HSF)-type, DNA-binding
Gene3DG3DSA:1.10.10.101.5E-38134227IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467859.11E-36134227IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF004473.4E-32138227IPR000232Heat shock factor (HSF)-type, DNA-binding
PRINTSPR000565.7E-20138161IPR000232Heat shock factor (HSF)-type, DNA-binding
PRINTSPR000565.7E-20176188IPR000232Heat shock factor (HSF)-type, DNA-binding
PROSITE patternPS004340177201IPR000232Heat shock factor (HSF)-type, DNA-binding
PRINTSPR000565.7E-20189201IPR000232Heat shock factor (HSF)-type, DNA-binding
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 349 aa     Download sequence    Send to blast
XSHHYLYSTL NSNPSKTDKP QFQPTSKMVL LAHAGSGGGQ ACSPPQFNKA IAEEKPVEMV  60
RVKSEQVTSS CRFLQQNDDV SSDESDKKKS NSEVTEEEEP RVKEEVADDG AVNVSSSSSS  120
VELPKPMEGL NEAGPPPFLR KTYEMVDDPE TDPIVSWSEN RDSFIVWESH EFAKVLLPKY  180
FKHSNFSSFI RQLNTYGFRK VDSDRWEFAN EGFQGGKKHL LKNIRRRSKY NKLHQGAFID  240
PAKPCLEAEV EKLKEDQNIL KLEILKLRQQ QESSHVHISS VQDRIQNVQT KQYQMIYFLT  300
RMARKPTFME QLLQKIKRKR ELDGTDMLKR RRLLEPTPSV DYRCQQGHX
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5d5u_B6e-251102271129Heat shock factor protein 1
5d5v_B6e-251102271129Heat shock factor protein 1
5d5v_D6e-251102271129Heat shock factor protein 1
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1317331RKRELDGTDMLKRRR
2328332KRRRL
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). Involved in heat stress responses. Seems to be involved in other environmental stress responses. Activates ascorbate peroxidase 2 (APX2) in addition to several heat shock protein (HSPs). {ECO:0000269|PubMed:16649111, ECO:0000269|PubMed:17059409, ECO:0000269|PubMed:17085506}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By heat stress, high light and hydrogen peroxide (H(2)O(2)). {ECO:0000269|PubMed:16649111, ECO:0000269|PubMed:17059409, ECO:0000269|PubMed:17085506}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_020999105.10.0heat stress transcription factor A-2 isoform X2
RefseqXP_025605794.10.0heat stress transcription factor A-2 isoform X2
SwissprotO809823e-80HSFA2_ARATH; Heat stress transcription factor A-2
TrEMBLA0A0B2PBI11e-130A0A0B2PBI1_GLYSO; Heat stress transcription factor A-2
TrEMBLA0A4P1R1U51e-130A0A4P1R1U5_LUPAN; Uncharacterized protein
TrEMBLI1LY111e-130I1LY11_SOYBN; Uncharacterized protein
STRINGGLYMA13G16510.11e-131(Glycine max)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G26150.16e-82heat shock transcription factor A2
Publications ? help Back to Top
  1. Liu HC,Charng YY
    Common and distinct functions of Arabidopsis class A1 and A2 heat shock factors in diverse abiotic stress responses and development.
    Plant Physiol., 2013. 163(1): p. 276-90
    [PMID:23832625]
  2. Jung HS, et al.
    Subset of heat-shock transcription factors required for the early response of Arabidopsis to excess light.
    Proc. Natl. Acad. Sci. U.S.A., 2013. 110(35): p. 14474-9
    [PMID:23918368]
  3. Chauhan H,Khurana N,Agarwal P,Khurana JP,Khurana P
    A seed preferential heat shock transcription factor from wheat provides abiotic stress tolerance and yield enhancement in transgenic Arabidopsis under heat stress environment.
    PLoS ONE, 2013. 8(11): p. e79577
    [PMID:24265778]
  4. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  5. Weng M, et al.
    Histone chaperone ASF1 is involved in gene transcription activation in response to heat stress in Arabidopsis thaliana.
    Plant Cell Environ., 2014. 37(9): p. 2128-38
    [PMID:24548003]
  6. Jang YH, et al.
    A homolog of splicing factor SF1 is essential for development and is involved in the alternative splicing of pre-mRNA in Arabidopsis thaliana.
    Plant J., 2014. 78(4): p. 591-603
    [PMID:24580679]
  7. Stief A, et al.
    Arabidopsis miR156 Regulates Tolerance to Recurring Environmental Stress through SPL Transcription Factors.
    Plant Cell, 2014. 26(4): p. 1792-1807
    [PMID:24769482]
  8. Dobrá J, et al.
    The impact of heat stress targeting on the hormonal and transcriptomic response in Arabidopsis.
    Plant Sci., 2015. 231: p. 52-61
    [PMID:25575991]
  9. Yamauchi Y,Kunishima M,Mizutani M,Sugimoto Y
    Reactive short-chain leaf volatiles act as powerful inducers of abiotic stress-related gene expression.
    Sci Rep, 2015. 5: p. 8030
    [PMID:25619826]
  10. Shi H, et al.
    Melatonin induces class A1 heat-shock factors (HSFA1s) and their possible involvement of thermotolerance in Arabidopsis.
    J. Pineal Res., 2015. 58(3): p. 335-42
    [PMID:25711624]
  11. Mueller SP,Krause DM,Mueller MJ,Fekete A
    Accumulation of extra-chloroplastic triacylglycerols in Arabidopsis seedlings during heat acclimation.
    J. Exp. Bot., 2015. 66(15): p. 4517-26
    [PMID:25977236]
  12. Nie S,Yue H,Xing D
    A Potential Role for Mitochondrial Produced Reactive Oxygen Species in Salicylic Acid-Mediated Plant Acquired Thermotolerance.
    Plant Physiol., 2016.
    [PMID:26099269]
  13. Nguyen AH, et al.
    Loss of Arabidopsis 5'-3' Exoribonuclease AtXRN4 Function Enhances Heat Stress Tolerance of Plants Subjected to Severe Heat Stress.
    Plant Cell Physiol., 2015. 56(9): p. 1762-72
    [PMID:26136597]
  14. Hu Z, et al.
    Histone acetyltransferase GCN5 is essential for heat stress-responsive gene activation and thermotolerance in Arabidopsis.
    Plant J., 2015. 84(6): p. 1178-91
    [PMID:26576681]
  15. Lämke J,Brzezinka K,Bäurle I
    HSFA2 orchestrates transcriptional dynamics after heat stress in Arabidopsis thaliana.
    Transcription, 2016. 7(4): p. 111-4
    [PMID:27383578]
  16. Wang X,Huang W,Liu J,Yang Z,Huang B
    Molecular regulation and physiological functions of a novel FaHsfA2c cloned from tall fescue conferring plant tolerance to heat stress.
    Plant Biotechnol. J., 2017. 15(2): p. 237-248
    [PMID:27500592]
  17. Chen ST,He NY,Chen JH,Guo FQ
    Identification of core subunits of photosystem II as action sites of HSP21, which is activated by the GUN5-mediated retrograde pathway in Arabidopsis.
    Plant J., 2017. 89(6): p. 1106-1118
    [PMID:27943531]
  18. Kataoka R,Takahashi M,Suzuki N
    Coordination between bZIP28 and HSFA2 in the regulation of heat response signals in Arabidopsis.
    Plant Signal Behav, 2017. 12(11): p. e1376159
    [PMID:28873003]
  19. Wang X,Zhuang L,Shi Y,Huang B
    Up-Regulation of HSFA2c and HSPs by ABA Contributing to Improved Heat Tolerance in Tall Fescue and Arabidopsis.
    Int J Mol Sci, 2018.
    [PMID:28914758]
  20. Llamas E,Pulido P,Rodriguez-Concepcion M
    Interference with plastome gene expression and Clp protease activity in Arabidopsis triggers a chloroplast unfolded protein response to restore protein homeostasis.
    PLoS Genet., 2017. 13(9): p. e1007022
    [PMID:28937985]
  21. Li X, et al.
    Plastid Translation Elongation Factor Tu Is Prone to Heat-Induced Aggregation Despite Its Critical Role in Plant Heat Tolerance.
    Plant Physiol., 2018. 176(4): p. 3027-3045
    [PMID:29444814]