PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AHYPO_019315-RA
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; Caryophyllales; Amaranthaceae; Amaranthus
Family bHLH
Protein Properties Length: 708aa    MW: 81739.7 Da    PI: 9.4055
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AHYPO_019315-RAgenomeBYUView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH11.90.0004136991048
                     HHHHHHHHHHHHHHHCTSCCC............................TTS-STCHHHHHHHH CS
              HLH 10 rrRRdriNsafeeLrellPkas.........................kapskKlsKaeiLekAv 48
                     rr R+ i ++f++ re+lP+++                         +a  +K +K+ iL  ++
  AHYPO_019315-RA 36 RRLRSSISDSFNRGRECLPQCFgtlgkyfsgsflheswskkkvldpqGAFLQKWNKIFILSCVI 99
                     899*******************999999999999999999999999999999999999987665 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF813241.57E-2780277No hitNo description
PfamPF005206.5E-3288404IPR005821Ion transport domain
Gene3DG3DSA:1.10.287.703.5E-1892275No hitNo description
Gene3DG3DSA:1.10.287.703.5E-18339399No hitNo description
SuperFamilySSF813241.57E-27339399No hitNo description
SuperFamilySSF512061.24E-35406600IPR018490Cyclic nucleotide-binding-like
Gene3DG3DSA:1.10.287.6307.7E-14406468No hitNo description
Gene3DG3DSA:2.60.120.109.8E-27475593IPR014710RmlC-like jelly roll fold
CDDcd000384.24E-17477606No hitNo description
PROSITE profilePS5004212.911477561IPR000595Cyclic nucleotide-binding domain
SMARTSM001005.3E-15477608IPR000595Cyclic nucleotide-binding domain
PfamPF000272.9E-7498587IPR000595Cyclic nucleotide-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006813Biological Processpotassium ion transport
GO:0006816Biological Processcalcium ion transport
GO:0055085Biological Processtransmembrane transport
GO:0005886Cellular Componentplasma membrane
GO:0005221Molecular Functionintracellular cyclic nucleotide activated cation channel activity
GO:0005242Molecular Functioninward rectifier potassium channel activity
GO:0005516Molecular Functioncalmodulin binding
Sequence ? help Back to Top
Protein Sequence    Length: 708 aa     Download sequence    Send to blast
MKYNQEKLVR FQGWVPQKSV DAQFYIQDDA RFGKFRRLRS SISDSFNRGR ECLPQCFGTL  60
GKYFSGSFLH ESWSKKKVLD PQGAFLQKWN KIFILSCVIA VSIDPLFFYI PVINNDKKCL  120
HLDHKLEVIA SVLRSFTDIF YVLHIVFQFR TGFIAPSSRV FGRGVLVEDG KEIAKRYMCS  180
YFWIDILAVL PLPQVAILII IPKLRGSRSL NTKNLLRFLV VFQYIPRIAR VFPLYKEVTR  240
TSGILTETAW AGAAFNLLLY MLAIGAFWYL FSIERETTCW RKACAMRTPC DLSALYCDLN  300
QGPVNNAYLN QSCPITSDNT GPFDFGMFLN ALTSGVVETT DFPKKFLFCF WWGLQNLSSL  360
GQNLQTSTYV WENLFAILIA IAGLVLFAFL IGNMQTYLQS ITTRLEEMRV KKRDAEQWMS  420
HRLLPQDLRD RIRRYEQYKW QETRGVDEES LILNLPKDLR RDIKRHLCLD LVTRVPMFEK  480
MDDQLLDAMC DCLKPVLYTQ SSCVIREGDP VDSMVFVMRG RLQSMTTNGG RTGFFNCEYL  540
KAGDFCGEEL LTWALDPNPS SNLPLSTRTV QTLTEVEAFA LLADDLKFVA SQFRRLHSKQ  600
LRHTFRHYSQ QWRTWAACFI QAAWRRYHRK KMEQSLKEEE DRLQDALARE AGSSSPSLGA  660
TIYASRFAAN ALRALRRNGV RKARLPERIS PILLQKPAEP DFSVEHQ*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1wgp_A6e-574725958131Probable cyclic nucleotide-gated ion channel 6
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtActs as cyclic nucleotide-gated ion channel. Can be activated by cyclic AMP which leads to an opening of the cation channel. May be responsible for cAMP-induced calcium entry in cells and thus should be involved in the calcium signal transduction. Could transport K(+), Na(+) and Pb(2+). {ECO:0000269|PubMed:11115134, ECO:0000269|PubMed:11842144}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_010671493.10.0PREDICTED: cyclic nucleotide-gated ion channel 1
RefseqXP_019104059.10.0PREDICTED: cyclic nucleotide-gated ion channel 1
SwissprotO657170.0CNGC1_ARATH; Cyclic nucleotide-gated ion channel 1
TrEMBLA0A0K9QQK00.0A0A0K9QQK0_SPIOL; Uncharacterized protein
STRINGXP_010671493.10.0(Beta vulgaris)
Publications ? help Back to Top
  1. Köhler C,Merkle T,Neuhaus G
    Characterisation of a novel gene family of putative cyclic nucleotide- and calmodulin-regulated ion channels in Arabidopsis thaliana.
    Plant J., 1999. 18(1): p. 97-104
    [PMID:10341447]
  2. Köhler C,Neuhaus G
    Characterisation of calmodulin binding to cyclic nucleotide-gated ion channels from Arabidopsis thaliana.
    FEBS Lett., 2000. 471(2-3): p. 133-6
    [PMID:10767408]
  3. Sunkar R, et al.
    Expression of a truncated tobacco NtCBP4 channel in transgenic plants and disruption of the homologous Arabidopsis CNGC1 gene confer Pb2+ tolerance.
    Plant J., 2000. 24(4): p. 533-42
    [PMID:11115134]
  4. Mäser P, et al.
    Phylogenetic relationships within cation transporter families of Arabidopsis.
    Plant Physiol., 2001. 126(4): p. 1646-67
    [PMID:11500563]
  5. Leng Q,Mercier RW,Hua BG,Fromm H,Berkowitz GA
    Electrophysiological analysis of cloned cyclic nucleotide-gated ion channels.
    Plant Physiol., 2002. 128(2): p. 400-10
    [PMID:11842144]
  6. Ali R,Zielinski RE,Berkowitz GA
    Expression of plant cyclic nucleotide-gated cation channels in yeast.
    J. Exp. Bot., 2006. 57(1): p. 125-38
    [PMID:16317039]
  7. Gobert A,Park G,Amtmann A,Sanders D,Maathuis FJ
    Arabidopsis thaliana cyclic nucleotide gated channel 3 forms a non-selective ion transporter involved in germination and cation transport.
    J. Exp. Bot., 2006. 57(4): p. 791-800
    [PMID:16449377]
  8. Ma W,Ali R,Berkowitz GA
    Characterization of plant phenotypes associated with loss-of-function of AtCNGC1, a plant cyclic nucleotide gated cation channel.
    Plant Physiol. Biochem., 2006 Jul-Sep. 44(7-9): p. 494-505
    [PMID:17027276]
  9. Kanter U,Hauser A,Michalke B,Dräxl S,Schäffner AR
    Caesium and strontium accumulation in shoots of Arabidopsis thaliana: genetic and physiological aspects.
    J. Exp. Bot., 2010. 61(14): p. 3995-4009
    [PMID:20624763]
  10. Wang YF, et al.
    Identification of cyclic GMP-activated nonselective Ca2+-permeable cation channels and associated CNGC5 and CNGC6 genes in Arabidopsis guard cells.
    Plant Physiol., 2013. 163(2): p. 578-90
    [PMID:24019428]