PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AHYPO_017472-RA
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; Caryophyllales; Amaranthaceae; Amaranthus
Family bHLH
Protein Properties Length: 626aa    MW: 68934.8 Da    PI: 5.4686
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AHYPO_017472-RAgenomeBYUView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH39.31.2e-12450495454
                      HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS
              HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 
                      +h e+Er+RR+++N++f  Lr ++P+       K++Ka+ L  A+ YI++L
  AHYPO_017472-RA 450 NHVEAERQRREKLNQRFYALRAVVPNV-----SKMDKASLLGDAISYINEL 495
                      799***********************6.....5***************998 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142152.2E-5036226IPR025610Transcription factor MYC/MYB N-terminal
PROSITE profilePS5088817.39446495IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474591.83E-19449524IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000831.99E-15449500No hitNo description
Gene3DG3DSA:4.10.280.107.2E-19450516IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000103.9E-10450495IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003531.4E-16452501IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006952Biological Processdefense response
GO:0009718Biological Processanthocyanin-containing compound biosynthetic process
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0043425Molecular FunctionbHLH transcription factor binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 626 aa     Download sequence    Send to blast
MMNFWSSNDI NGSVSSSSSP LLMDSFPPSN SAQDTLHTRL QALIDNPVTF RGETWTYAIF  60
WQYSVDYSGQ ALLGWGDGYY RGEENKTRKD SNKPASNRIS HDLAEQEHRK RVLRELNSLI  120
SGAPAPEDSA VEEEVTDTEW FFLISMTNTF ASGEDLPGQA HFSSTPIWAA GLDRLSSSPC  180
NRAKQGSCFG LQTMVSIPVL NGVLELGSTE VIFQTPELMN KVRILFCFGS GSGVGDPSAW  240
PVPIPVPIQT PVPSSESDPT AMWINDPNPP EIVKEIRKTP TPPPPLQPQP KLINLDTPIK  300
NNNPGEIQNT QSKSEFFSKE LNFSEYAGFT GNGSKPNGGV KPESGEILSF GGNGSVKPDS  360
KFVMEDTTYK KKRSPNSRGS NEEGMMSFTS GVILASSAVK SSNNGGIDSE HSDLEASIKE  420
VDSCRVIPEP EKRPRKRGRK PANGREEPLN HVEAERQRRE KLNQRFYALR AVVPNVSKMD  480
KASLLGDAIS YINELKSKLQ NFESEKEELV TQMEALKKEL VTLPPSPPHI EKGQNVLAGK  540
PLMDLEVDVK IIGWEAMIRV NCNKKNHPAA RLMAALKELD LDVSHASVSV VNELMIQQAT  600
VKMGNSIELQ PFLEYISTHK ATMME*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4rru_A3e-573322245227Transcription factor MYC3
4ywc_A3e-573322245227Transcription factor MYC3
4ywc_B3e-573322245227Transcription factor MYC3
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1431439KRPRKRGRK
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional activator that binds to the G-box motif (5'-AACGTG-3') found in the promoter of the jasmonate-induced gene LAPA1 (PubMed:15231736). Acts as negative regulator of blue light-mediated photomorphogenesis and positively regulates root growth (PubMed:24483714). Promotes growth in response to the phytohormones abscisic acid (ABA) and jasmonate (JA) (PubMed:24483714). Binds to the G-box motif (5'-CACGTG-3') of the RBCS-3A gene promoter (PubMed:24483714). Acts downstream of the jasmonate (JA) receptor to orchestrate JA-mediated activation of plant responses (PubMed:28733419). Positively regulates both wound-responsive and pathogen-responsive genes through MYC2-targeted transcription factors (MTFs) involved in early response to JA (PubMed:28733419). With JA2L forms a transcription module that regulates wounding-responsive genes (PubMed:28733419). With ERF.C3 forms a transcription module that regulates pathogen-responsive genes (PubMed:28733419). Plays a critical role in orchestrating JA-mediated defense gene expression during Botrytis cinerea infection (PubMed:28733419). Regulates negatively defense responses to root-knot nematodes, potentially by mediating crosstalk among the hormones strigolactones, abscisic acid (ABA) and jasmonate (JA) (PubMed:30576511). Regulates the termination of JA-mediated defense responses by specifically binding the G-box (5'-CACATG-3') motifs in the promoters of MTB1, MTB2 and MTB3, which are transcription factors that negatively regulates JA signaling (PubMed:30610166). May be involved in JA-induced chilling tolerance, possibly by ameliorating the antioxidant enzyme system of fruit and increasing proline and lycopene levels (PubMed:29528226). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:24483714, ECO:0000269|PubMed:28733419, ECO:0000269|PubMed:29528226, ECO:0000269|PubMed:30576511, ECO:0000269|PubMed:30610166}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00086PBMTransfer from AT4G17880Download
Motif logo
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by methyl jasmonate (PubMed:15231736, PubMed:28733419). Induced by wounding (PubMed:15231736). Induced by infection with the fungal pathogen Botrytis cinerea (PubMed:28733419). Induced in fruit by storage in cold (PubMed:29528226). Induced by hydrogen peroxide and infection with root-knot nematodes (PubMed:30576511). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:28733419, ECO:0000269|PubMed:29528226, ECO:0000269|PubMed:30576511}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_021765652.10.0LOW QUALITY PROTEIN: transcription factor MYC2-like
SwissprotA0A3Q7HRZ60.0MYC2_SOLLC; Transcription factor MYC2
TrEMBLA0A0K9RA930.0A0A0K9RA93_SPIOL; Uncharacterized protein
STRINGXP_010677236.10.0(Beta vulgaris)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G17880.11e-158bHLH family protein
Publications ? help Back to Top
  1. Tomato Genome Consortium
    The tomato genome sequence provides insights into fleshy fruit evolution.
    Nature, 2012. 485(7400): p. 635-41
    [PMID:22660326]
  2. Gupta N,Prasad VB,Chattopadhyay S
    LeMYC2 acts as a negative regulator of blue light mediated photomorphogenic growth, and promotes the growth of adult tomato plants.
    BMC Plant Biol., 2014. 14: p. 38
    [PMID:24483714]
  3. Sun H,Fan HJ,Ling HQ
    Genome-wide identification and characterization of the bHLH gene family in tomato.
    BMC Genomics, 2015. 16: p. 9
    [PMID:25612924]
  4. Du M, et al.
    MYC2 Orchestrates a Hierarchical Transcriptional Cascade That Regulates Jasmonate-Mediated Plant Immunity in Tomato.
    Plant Cell, 2017. 29(8): p. 1883-1906
    [PMID:28733419]
  5. Min D, et al.
    SlMYC2 Involved in Methyl Jasmonate-Induced Tomato Fruit Chilling Tolerance.
    J. Agric. Food Chem., 2018. 66(12): p. 3110-3117
    [PMID:29528226]
  6. Xu X, et al.
    Strigolactones positively regulate defense against root-knot nematodes in tomato.
    J. Exp. Bot., 2019. 70(4): p. 1325-1337
    [PMID:30576511]
  7. Liu Y, et al.
    MYC2 Regulates the Termination of Jasmonate Signaling via an Autoregulatory Negative Feedback Loop.
    Plant Cell, 2019. 31(1): p. 106-127
    [PMID:30610166]