PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Aradu.K3S1H
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Dalbergieae; Arachis
Family E2F/DP
Protein Properties Length: 471aa    MW: 51564.6 Da    PI: 5.0792
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Aradu.K3S1HgenomeNCGR_PGCView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP84.96.1e-27151216171
      E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                  r+++sL++lt+kf++l+++se+g+++ln++a++L   +v  k+RRiYDi+NVLe+++liekk kn+i+wkg
  Aradu.K3S1H 151 RYDNSLGMLTKKFVNLVKHSEDGNLDLNQAAETL---EV--KKRRIYDITNVLEGIGLIEKKLKNRIHWKG 216
                  689*******************************...99..9***************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.3E-28148218IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.41E-17151214IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013725.7E-34151216IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023199.7E-25153216IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440748.11E-32228332No hitNo description
PfamPF164211.1E-32231330IPR032198E2F transcription factor, CC-MB domain
CDDcd146603.14E-47231332No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 471 aa     Download sequence    Send to blast
MSGGAGPPPQ HTKPDDSGVP IRPPLKRHLA FASMKPSFAQ PDEYHSFSSS SGAPDSGRKL  60
AADQQAEVVV VRSPHIKRKG GMTNIEGDSQ KLSNVPGSAN AASSPFKTPV SSKGGRTHAK  120
SKVSKEGMQC PQTPISNSGS PSPLTPAGSC RYDNSLGMLT KKFVNLVKHS EDGNLDLNQA  180
AETLEVKKRR IYDITNVLEG IGLIEKKLKN RIHWKGTESS SGDVDGDISM LKEEVERLSL  240
EEHRLDDRIR EMQERLRSLS EDENKQKFLF VTEEDIKAVP CFQNETLIAI KAPHGTTLEV  300
PDPEEAVDYL QRRYRIILRS TMGPIDVYLI SQFEERFEEI NGPEPPVSLP LPSSSGSNEP  360
PVAETVPAEC SAKGLEPQPQ IPSHTYSDLN TSQDFGGGMM KIVPSDADND ADYWLLSDAD  420
ISITDMWRTD SSVDWNGVDM LHPDFGNIPR PQTPSSGIAE TPSTVTNPNQ R
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A1e-22146217274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapAradu.K3S1H
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankBT0930465e-61BT093046.1 Soybean clone JCVI-FLGm-15I8 unknown mRNA.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_015951408.10.0transcription factor E2FA
SwissprotQ9FNY01e-158E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A445E7B20.0A0A445E7B2_ARAHY; Uncharacterized protein
STRINGAES627030.0(Medicago truncatula)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-151E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]