PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Aradu.DRR9K
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Dalbergieae; Arachis
Family bHLH
Protein Properties Length: 464aa    MW: 51190.7 Da    PI: 6.7008
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Aradu.DRR9KgenomeNCGR_PGCView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH35.32e-11267309754
                  HHHHHHHHHHHHHHHHHHCTSCC.C...TTS-STCHHHHHHHHHHHHHH CS
          HLH   7 erErrRRdriNsafeeLrellPk.askapskKlsKaeiLekAveYIksL 54 
                  ++ErrRR+++N+++  Lr+++Pk +      K++ a+iL  A+eY+++L
  Aradu.DRR9K 267 MAERRRRKKLNDRLYMLRSVVPKiS------KMDRASILGDAIEYLREL 309
                  79*********************66......***************998 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5088815.675260309IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474593.93E-16263322IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003538.2E-14266315IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000104.6E-9266309IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000834.96E-12267313No hitNo description
Gene3DG3DSA:4.10.280.101.9E-15267322IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd048734.39E-5393453No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0010440Biological Processstomatal lineage progression
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0050826Biological Processresponse to freezing
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 464 aa     Download sequence    Send to blast
MMSSSWASME AETEHQQQTH NDRDFTSLCS FNNNLPFMEV DDVNDIMMMM TMMRDMSNFF  60
PEPDTTNNNN LVLLHHHSSS SSSSSSSSSH LQCFLPPPPP PNPFDMPTMA SFLDPHQASI  120
TATTDFGGFH HHNLEELGSC SSSGKPAPPP PPPLFFNRSK ILRPLDDSLP PSGAQPTLFQ  180
KRAALRKNNS SSQQQQGGVL GEDDNNNNKN SMKRKVMMEM EDNGSFDGSS AFNYDSGDDL  240
IETNNKKNNQ KGGGGKNKKG MPAKNLMAER RRRKKLNDRL YMLRSVVPKI SKMDRASILG  300
DAIEYLRELL QRINELHNEL ESSSSTSTNS GSGSVMTAVP TVVASSSFYP LTPTPPSLPT  360
RIKEEICPTS LPSPNAQPPR VDVRLREGRA VNIHMFCGRK AGLLLSTMRA LDTLGLDIQQ  420
AVISCFNGFA LDIFRAEQCK EGQDVHPEQI KAVLLDTAGY PAII
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5gnj_A1e-13262319663Transcription factor MYC2
5gnj_B1e-13262319663Transcription factor MYC2
5gnj_E1e-13262319663Transcription factor MYC2
5gnj_F1e-13262319663Transcription factor MYC2
5gnj_G1e-13262319663Transcription factor MYC2
5gnj_I1e-13262319663Transcription factor MYC2
5gnj_M1e-13262319663Transcription factor MYC2
5gnj_N1e-13262319663Transcription factor MYC2
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1268275ERRRRKKL
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional activator that regulates the cold-induced transcription of CBF/DREB1 genes. Binds specifically to the MYC recognition sites (5'-CANNTG-3') found in the CBF3/DREB1A promoter. Mediates stomatal differentiation in the epidermis probably by controlling successive roles of SPCH, MUTE, and FAMA. Functions as a dimer with SPCH during stomatal initiation (PubMed:18641265, PubMed:28507175). {ECO:0000269|PubMed:17416732, ECO:0000269|PubMed:18641265, ECO:0000269|PubMed:28507175}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapAradu.DRR9K
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By high-salt stress, cold stress and abscisic acid (ABA) treatment.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_015937933.10.0transcription factor SCREAM2
SwissprotQ9LSE21e-113ICE1_ARATH; Transcription factor ICE1
TrEMBLA0A445C1V60.0A0A445C1V6_ARAHY; Uncharacterized protein
STRINGGLYMA04G37750.21e-144(Glycine max)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF24143482
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G26744.41e-104bHLH family protein
Publications ? help Back to Top
  1. Chen Y, et al.
    Ambient temperature enhanced freezing tolerance of Chrysanthemum dichrum CdICE1 Arabidopsis via miR398.
    BMC Biol., 2013. 11: p. 121
    [PMID:24350981]
  2. Xu F, et al.
    Increased drought tolerance through the suppression of ESKMO1 gene and overexpression of CBF-related genes in Arabidopsis.
    PLoS ONE, 2014. 9(9): p. e106509
    [PMID:25184213]
  3. Jiang W,Wu J,Zhang Y,Yin L,Lu J
    Isolation of a WRKY30 gene from Muscadinia rotundifolia (Michx) and validation of its function under biotic and abiotic stresses.
    Protoplasma, 2015. 252(5): p. 1361-74
    [PMID:25643917]
  4. Lang Z,Zhu J
    OST1 phosphorylates ICE1 to enhance plant cold tolerance.
    Sci China Life Sci, 2015. 58(3): p. 317-8
    [PMID:25680856]
  5. Juan JX, et al.
    Agrobacterium-mediated transformation of tomato with the ICE1 transcription factor gene.
    Genet. Mol. Res., 2015. 14(1): p. 597-608
    [PMID:25729995]
  6. Lee HG,Seo PJ
    The MYB96-HHP module integrates cold and abscisic acid signaling to activate the CBF-COR pathway in Arabidopsis.
    Plant J., 2015. 82(6): p. 962-77
    [PMID:25912720]
  7. Horst RJ, et al.
    Molecular Framework of a Regulatory Circuit Initiating Two-Dimensional Spatial Patterning of Stomatal Lineage.
    PLoS Genet., 2015. 11(7): p. e1005374
    [PMID:26203655]
  8. Lee JH,Jung JH,Park CM
    INDUCER OF CBF EXPRESSION 1 integrates cold signals into FLOWERING LOCUS C-mediated flowering pathways in Arabidopsis.
    Plant J., 2015. 84(1): p. 29-40
    [PMID:26248809]
  9. Wang CL,Zhang SC,Qi SD,Zheng CC,Wu CA
    Delayed germination of Arabidopsis seeds under chilling stress by overexpressing an abiotic stress inducible GhTPS11.
    Gene, 2016. 575(2 Pt 1): p. 206-12
    [PMID:26325072]
  10. Lee JH,Park CM
    Integration of photoperiod and cold temperature signals into flowering genetic pathways in Arabidopsis.
    Plant Signal Behav, 2015. 10(11): p. e1089373
    [PMID:26430754]
  11. Su F, et al.
    Burkholderia phytofirmans PsJN reduces impact of freezing temperatures on photosynthesis in Arabidopsis thaliana.
    Front Plant Sci, 2015. 6: p. 810
    [PMID:26483823]
  12. Klermund C, et al.
    LLM-Domain B-GATA Transcription Factors Promote Stomatal Development Downstream of Light Signaling Pathways in Arabidopsis thaliana Hypocotyls.
    Plant Cell, 2016. 28(3): p. 646-60
    [PMID:26917680]
  13. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  14. Lu X, et al.
    A novel Zea mays ssp. mexicana L. MYC-type ICE-like transcription factor gene ZmmICE1, enhances freezing tolerance in transgenic Arabidopsis thaliana.
    Plant Physiol. Biochem., 2017. 113: p. 78-88
    [PMID:28189052]
  15. Deng C,Ye H,Fan M,Pu T,Yan J
    The rice transcription factors OsICE confer enhanced cold tolerance in transgenic Arabidopsis.
    Plant Signal Behav, 2017. 12(5): p. e1316442
    [PMID:28414264]
  16. de Marcos A, et al.
    A Mutation in the bHLH Domain of the SPCH Transcription Factor Uncovers a BR-Dependent Mechanism for Stomatal Development.
    Plant Physiol., 2017. 174(2): p. 823-842
    [PMID:28507175]
  17. Kim SH, et al.
    Phosphorylation of the transcriptional repressor MYB15 by mitogen-activated protein kinase 6 is required for freezing tolerance in Arabidopsis.
    Nucleic Acids Res., 2017. 45(11): p. 6613-6627
    [PMID:28510716]
  18. Pal S, et al.
    TransDetect Identifies a New Regulatory Module Controlling Phosphate Accumulation.
    Plant Physiol., 2017. 175(2): p. 916-926
    [PMID:28827455]
  19. Zhao C, et al.
    MAP Kinase Cascades Regulate the Cold Response by Modulating ICE1 Protein Stability.
    Dev. Cell, 2017. 43(5): p. 618-629.e5
    [PMID:29056551]
  20. Li H, et al.
    MPK3- and MPK6-Mediated ICE1 Phosphorylation Negatively Regulates ICE1 Stability and Freezing Tolerance in Arabidopsis.
    Dev. Cell, 2017. 43(5): p. 630-642.e4
    [PMID:29056553]
  21. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  22. Liu Y,Zhou J
    MAPping Kinase Regulation of ICE1 in Freezing Tolerance.
    Trends Plant Sci., 2018. 23(2): p. 91-93
    [PMID:29248419]
  23. Xie H, et al.
    Variation in ICE1 Methylation Primarily Determines Phenotypic Variation in Freezing Tolerance in Arabidopsis thaliana.
    Plant Cell Physiol., 2019. 60(1): p. 152-165
    [PMID:30295898]