PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Aradu.891N0
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Dalbergieae; Arachis
Family E2F/DP
Protein Properties Length: 483aa    MW: 53818.1 Da    PI: 5.0096
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Aradu.891N0genomeNCGR_PGCView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP83.71.4e-26132207171
      E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.........dvknkrRRiYDilNVLealnliekkekneirwkg 71 
                  r+++sL+llt+kf++l++++e+gi++ln++a++L  e         +v  ++RRiYDi+NVLe+++liekk kn+i+wkg
  Aradu.891N0 132 RYDSSLGLLTKKFINLIKQAEDGILDLNKAAETL--EirgikvdylKV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 207
                  6899******************************..778****96656..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.9E-27128209IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.06E-14132205IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013726.2E-32132207IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023195.8E-24134207IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146601.71E-39218320No hitNo description
SuperFamilySSF1440743.66E-29221322No hitNo description
PfamPF164214.1E-28223320IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 483 aa     Download sequence    Send to blast
MKRQVPLPST KPPFAPPADY HRFATDHRTT SQNDADAIAV KTPIATEMDF VPQIQQLKRK  60
SVTTDLEGDS GNVTPASTEA VNSPFRTPIS RKTGKASKSS RLTKCNRSGS QIPGSNISSP  120
SANNLAPSGP CRYDSSLGLL TKKFINLIKQ AEDGILDLNK AAETLEIRGI KVDYLKVQKR  180
RIYDITNVLE GIGLIEKKLK NRIQWKGLDV SRPGQAVDSF ASLQAEVENL TNEEHRLDEQ  240
IREMQERLRG LSEDENTQRY LFVTEEDIKS LPSSQNETLI AIKAPYCTTL EVPDPDEVVD  300
YPQRKYRIIL RSSTGPIDSF CWGNGNCKMQ YDDIPDLFSS HCHASQFEEK FEINGVNVAP  360
NIPSRPDFNK HQSTVVSNDR GKDLEMGIQD VYRPSDLSNS HDFAGGITKI VPSDFESDAD  420
YWLLSDADVS ITDMWRTEPG EVEWHNLDTP KEDYCMTHVS PPPPQTPPSN ISEAPSASNP  480
PVA
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A7e-26127208274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1174180LKVQKRR
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapAradu.891N0
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269|PubMed:16055635, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_020984925.10.0transcription factor E2FB isoform X2
SwissprotQ9FV711e-128E2FB_ARATH; Transcription factor E2FB
TrEMBLA0A445BWJ60.0A0A445BWJ6_ARAHY; Uncharacterized protein
STRINGAES882920.0(Medicago truncatula)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G22220.21e-129E2F transcription factor 1
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Wu M,Liu L,Hijazi H,Chan C
    A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
    Bioinformatics, 2013. 29(12): p. 1541-52
    [PMID:23610368]
  3. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]