PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID KFK38438.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Arabideae; Arabis
Family NAC
Protein Properties Length: 558aa    MW: 62683 Da    PI: 4.2169
Description NAC family protein
Gene Model
Gene Model ID Type Source Coding Sequence
KFK38438.1genomeMPIPBRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1NAM168.91.7e-5271341128
         NAM   1 lppGfrFhPtdeelvveyLkkkvegkkleleevikevdiykvePwdLp.k.kvkaeekewyfFskrdkkyatgkrknratksgyWkatgkdkevlskkg 97 
                 l+pGfrFhPtdeelv++yLk+k+ +k+l++ ++i+ +d+yk+ePwdLp k k+k+++ ewyfFs  dkky++g ++nrat++gyWk+tgkd+e+   ++
  KFK38438.1   7 LAPGFRFHPTDEELVCYYLKRKICNKPLKF-DAISVTDVYKSEPWDLPdKsKLKSRDLEWYFFSMLDKKYRNGLKTNRATENGYWKTTGKDREIRY-GS 103
                 579**************************9.99**************95347777888*************************************9.9* PP

         NAM  98 elvglkktLvfykgrapkgektdWvmheyrl 128
                 ++vg+kktLv++kgrap+ge+t+Wvmheyrl
  KFK38438.1 104 RVVGMKKTLVYHKGRAPRGERTNWVMHEYRL 134
                 *****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF1019413.14E-615160IPR003441NAC domain
PROSITE profilePS5100558.2167160IPR003441NAC domain
PfamPF023655.5E-289134IPR003441NAC domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0009819Biological Processdrought recovery
GO:0010150Biological Processleaf senescence
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:2000377Biological Processregulation of reactive oxygen species metabolic process
GO:0005634Cellular Componentnucleus
GO:0005737Cellular Componentcytoplasm
GO:0005886Cellular Componentplasma membrane
GO:0016021Cellular Componentintegral component of membrane
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 558 aa     Download sequence    Send to blast
MGRGSSLAPG FRFHPTDEEL VCYYLKRKIC NKPLKFDAIS VTDVYKSEPW DLPDKSKLKS  60
RDLEWYFFSM LDKKYRNGLK TNRATENGYW KTTGKDREIR YGSRVVGMKK TLVYHKGRAP  120
RGERTNWVMH EYRLVSEDTD KEKKTGVQQD SYVLCRIFQK SGTGPKNGEN YGAPFVEEEW  180
EEDDMVFVPG QDLGSEDCVY VDVDEFDQKL DNALVYDAVP IPLNFDYGES SNNAETNYSD  240
SNKYMQPGNY VDSNIYFEQP AEFSEGGQKP IIGDGSLQND ALFPDEGNGC GVQDDSTANL  300
QSSDNIFESD TSRYNEYPGE SNYFTGEAFL DPNNSLLQND GLFLETNDLG STQQDGFDYE  360
DYLTFFDEDD ENLTFDPSQL IGTEDVIPDQ EELFQKAETK ELEKEEASGG KQVVEEKEKD  420
EASCSKQVDA YATEFEPDYK YSFLKKASNM LGAIPAPPAF ASEFPAKDAS IQLHAAQSSG  480
SVHVTAGMIT ISDSNTSWSY GKDGNGNLEL ILSFGLAQGN AASEKSGNSL TRAMFMFMCF  540
WVLVLSISFK VSTLVSSR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
3ulx_A5e-45616014168Stress-induced transcription factor NAC1
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP) (Ref.6, PubMed:24323506, PubMed:25219309). Promotes reactive oxygen species (ROS) production during drought-induced leaf senescence. In response to abscisic acid (ABA)-mediated drought stress signals, binds directly to the promoters of RBOHC and RBOHE genes, encoding ROS biosynthetic enzymes, resulting in ROS accumulation and triggering leaf senescence via programmed cell death (PCD). ROS-induced leaf senescence sustains plant survival under drought conditions (PubMed:22313226). Involved in heat stress response. Modulates PCD through a ROS-mediated positive feedback control under heat stress conditions. This may provide an adaptation strategy for plant survival under extreme heat stress conditions (PubMed:25219309). Acts as repressor in preventing anther dehiscence during stamen development by suppressing genes that participate in jasmonic acid (JA) biosynthesis, such as DAD1, AOS, AOC3, OPR3 and 4CLL5/OPCL1 (PubMed:24323506). {ECO:0000269|PubMed:22313226, ECO:0000269|PubMed:24323506, ECO:0000269|PubMed:25219309, ECO:0000269|Ref.6}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00343DAPTransfer from AT3G10500Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapKFK38438.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By abscisic acid (ABA) (PubMed:22313226, PubMed:25219309). Induced by heat shock (PubMed:25219309). Induced by cold, drought stress and methyl methanesulfonate (MMS) treatment (PubMed:17158162). {ECO:0000269|PubMed:17158162, ECO:0000269|PubMed:22313226, ECO:0000269|PubMed:25219309}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_020886650.10.0NAC domain-containing protein 53
SwissprotQ949N00.0NAC53_ARATH; NAC domain-containing protein 53
TrEMBLA0A087H8I60.0A0A087H8I6_ARAAL; Uncharacterized protein
STRINGA0A087H8I60.0(Arabis alpina)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM31922762
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G10500.10.0NAC domain containing protein 53
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  3. Vermeirssen V,De Clercq I,Van Parys T,Van Breusegem F,Van de Peer Y
    Arabidopsis ensemble reverse-engineered gene regulatory network discloses interconnected transcription factors in oxidative stress.
    Plant Cell, 2014. 26(12): p. 4656-79
    [PMID:25549671]
  4. Gladman NP,Marshall RS,Lee KH,Vierstra RD
    The Proteasome Stress Regulon Is Controlled by a Pair of NAC Transcription Factors in Arabidopsis.
    Plant Cell, 2016. 28(6): p. 1279-96
    [PMID:27194708]
  5. Sanz-Fernández M, et al.
    Screening Arabidopsis mutants in genes useful for phytoremediation.
    J. Hazard. Mater., 2017. 335: p. 143-151
    [PMID:28441590]