PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Salvia splendens
E2F/DP Family
Species TF ID Description
TEY13129.1E2F/DP family protein
TEY14738.1E2F/DP family protein
TEY18632.1E2F/DP family protein
TEY25761.1E2F/DP family protein
TEY27540.1E2F/DP family protein
TEY33741.1E2F/DP family protein
TEY39940.1E2F/DP family protein
TEY41273.1E2F/DP family protein
TEY49669.1E2F/DP family protein
TEY52328.1E2F/DP family protein
TEY59279.1E2F/DP family protein
TEY63957.1E2F/DP family protein
TEY72938.1E2F/DP family protein
TEY74516.1E2F/DP family protein
TEY74518.1E2F/DP family protein
TEY77010.1E2F/DP family protein
TEY88434.1E2F/DP family protein
TEY89074.1E2F/DP family protein
TEY90212.1E2F/DP family protein
TEY92372.1E2F/DP family protein
E2F/DP Family Introduction

E2F transcription factors are a family of proteins that share a related DNA-binding domain and that bind to overlapping sets of target promoters. Most E2F proteins associate with a DP protein and form heterodimeric complexes that bind to DNA in a sequence-specific manner. E2F proteins control the temporal expression of genes that are needed for multiple processes during the cell cycle. Consequently, the level of E2F-dependent transcription is important for cell proliferation.

Different types of E2F complexes either activate or repress transcription. E2F repressor complexes suppress the transcription of their targets in quiescent cells, in differentiated cells and during the G1 phase of the cell cycle. When cells enter the cell cycle and proliferate, these repressors are disrupted and/or replaced by activator forms of E2F that promote gene expression.

van den Heuvel S, Dyson NJ.
Conserved functions of the pRB and E2F families.
Nat Rev Mol Cell Biol, 2008. 9(9): p. 713-24.
PMID: 18719710