PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Herrania umbratica
E2F/DP Family
Species TF ID Description
XP_021278199.1E2F/DP family protein
XP_021278200.1E2F/DP family protein
XP_021284606.1E2F/DP family protein
XP_021284607.1E2F/DP family protein
XP_021289090.1E2F/DP family protein
XP_021289091.1E2F/DP family protein
XP_021289599.1E2F/DP family protein
XP_021289600.1E2F/DP family protein
XP_021289601.1E2F/DP family protein
XP_021289739.1E2F/DP family protein
XP_021292037.1E2F/DP family protein
XP_021292038.1E2F/DP family protein
XP_021297822.1E2F/DP family protein
XP_021297824.1E2F/DP family protein
XP_021297825.1E2F/DP family protein
XP_021297826.1E2F/DP family protein
XP_021297827.1E2F/DP family protein
E2F/DP Family Introduction

E2F transcription factors are a family of proteins that share a related DNA-binding domain and that bind to overlapping sets of target promoters. Most E2F proteins associate with a DP protein and form heterodimeric complexes that bind to DNA in a sequence-specific manner. E2F proteins control the temporal expression of genes that are needed for multiple processes during the cell cycle. Consequently, the level of E2F-dependent transcription is important for cell proliferation.

Different types of E2F complexes either activate or repress transcription. E2F repressor complexes suppress the transcription of their targets in quiescent cells, in differentiated cells and during the G1 phase of the cell cycle. When cells enter the cell cycle and proliferate, these repressors are disrupted and/or replaced by activator forms of E2F that promote gene expression.

van den Heuvel S, Dyson NJ.
Conserved functions of the pRB and E2F families.
Nat Rev Mol Cell Biol, 2008. 9(9): p. 713-24.
PMID: 18719710