PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Cucurbita pepo subsp. pepo
E2F/DP Family
Species TF ID Description
XP_023511801.1E2F/DP family protein
XP_023516240.1E2F/DP family protein
XP_023518575.1E2F/DP family protein
XP_023519127.1E2F/DP family protein
XP_023519128.1E2F/DP family protein
XP_023519129.1E2F/DP family protein
XP_023519131.1E2F/DP family protein
XP_023534186.1E2F/DP family protein
XP_023534187.1E2F/DP family protein
XP_023536263.1E2F/DP family protein
XP_023536267.1E2F/DP family protein
XP_023537864.1E2F/DP family protein
XP_023541653.1E2F/DP family protein
XP_023541654.1E2F/DP family protein
XP_023543731.1E2F/DP family protein
XP_023543732.1E2F/DP family protein
XP_023543733.1E2F/DP family protein
XP_023543734.1E2F/DP family protein
XP_023543735.1E2F/DP family protein
XP_023547197.1E2F/DP family protein
XP_023553484.1E2F/DP family protein
E2F/DP Family Introduction

E2F transcription factors are a family of proteins that share a related DNA-binding domain and that bind to overlapping sets of target promoters. Most E2F proteins associate with a DP protein and form heterodimeric complexes that bind to DNA in a sequence-specific manner. E2F proteins control the temporal expression of genes that are needed for multiple processes during the cell cycle. Consequently, the level of E2F-dependent transcription is important for cell proliferation.

Different types of E2F complexes either activate or repress transcription. E2F repressor complexes suppress the transcription of their targets in quiescent cells, in differentiated cells and during the G1 phase of the cell cycle. When cells enter the cell cycle and proliferate, these repressors are disrupted and/or replaced by activator forms of E2F that promote gene expression.

van den Heuvel S, Dyson NJ.
Conserved functions of the pRB and E2F families.
Nat Rev Mol Cell Biol, 2008. 9(9): p. 713-24.
PMID: 18719710