PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Zoysia pacifica
GeBP Family
Species TF ID Description
Zpz_sc00002.1.g00420.1.am.mkGeBP family protein
Zpz_sc00150.1.g00320.1.sm.mkGeBP family protein
Zpz_sc00223.1.g00240.1.am.mkGeBP family protein
Zpz_sc00228.1.g00060.1.am.mkGeBP family protein
Zpz_sc00322.1.g00060.1.sm.mkGeBP family protein
Zpz_sc00452.1.g00020.1.sm.mkGeBP family protein
Zpz_sc00499.1.g00050.1.am.mkGeBP family protein
Zpz_sc00703.1.g00090.1.am.mkGeBP family protein
Zpz_sc00713.1.g00110.1.am.mkGeBP family protein
Zpz_sc00713.1.g00260.1.am.mkGeBP family protein
Zpz_sc00717.1.g00310.1.am.mkGeBP family protein
Zpz_sc01083.1.g00150.1.am.mkGeBP family protein
Zpz_sc01135.1.g00140.1.sm.mkGeBP family protein
Zpz_sc01158.1.g00150.1.am.mkGeBP family protein
Zpz_sc01412.1.g00050.1.sm.mkGeBP family protein
Zpz_sc01429.1.g00170.1.am.mkGeBP family protein
Zpz_sc01514.1.g00050.1.es.mkhcGeBP family protein
Zpz_sc01820.1.g00070.1.sm.mkGeBP family protein
Zpz_sc02399.1.g00100.1.sm.mkGeBP family protein
Zpz_sc02487.1.g00010.1.am.mkGeBP family protein
Zpz_sc05572.1.g00020.1.am.mkGeBP family protein
GeBP Family Introduction

Understanding the role of transcription factors (TFs) is essential in reconstructing developmental regulatory networks. The plant-specific GeBP TF family of Arabidopsis thaliana (Arabidopsis) comprises 21 members, all of unknown function. A subset of four members, the founding member GeBP and GeBP-like proteins (GPL) 1, 2, and 3, shares a conserved C-terminal domain. Here we report that GeBP/GPL genes represent a newly defined class of leucine-zipper (Leu-zipper) TFs and that they play a redundant role in cytokinin hormone pathway regulation. Specifically, we demonstrate using yeast, in vitro, and split-yellow fluorescent protein in planta assays that GeBP/GPL proteins form homo- and heterodimers through a noncanonical Leu-zipper motif located in the C-terminal domain. A triple loss-of-function mutant of the three most closely related genes gebp gpl1 gpl2 shows a reduced sensitivity to exogenous cytokinins in a subset of cytokinin responses such as senescence and growth, whereas root inhibition is not affected. We find that transcript levels of type-A cytokinin response genes, which are involved in the negative feedback regulation of cytokinin signaling, are higher in the triple mutant. Using a GPL version that acts as a constitutive transcriptional activator, we show that the regulation of Arabidopsis response regulators (ARRs) is mediated by at least one additional, as yet unknown, repressor acting genetically downstream in the GeBP/GPL pathway. Our results indicate that GeBP/GPL genes encode a new class of unconventional Leu-zipper TF proteins and suggest that their role in the cytokinin pathway is to antagonize the negative feedback regulation on ARR genes to trigger the cytokinin response.

Chevalier F, Perazza D, Laporte F, Le Henanff G, Hornitschek P, Bonneville JM, Herzog M, Vachon G
GeBP and GeBP-Like Proteins Are Noncanonical Leucine-Zipper Transcription Factors That Regulate Cytokinin Response in Arabidopsis
Plant Physiol. 2008 Mar;146(3):1142-54.
PMID: 18162594