PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Zostera marina
HD-ZIP Family
Species TF ID Description
Zosma20g00250.1HD-ZIP family protein
Zosma248g00110.1HD-ZIP family protein
Zosma23g01260.1HD-ZIP family protein
Zosma91g00670.1HD-ZIP family protein
Zosma182g00060.1HD-ZIP family protein
Zosma203g00180.1HD-ZIP family protein
Zosma6g02120.1HD-ZIP family protein
Zosma77g00560.1HD-ZIP family protein
Zosma54g00840.1HD-ZIP family protein
Zosma99g00110.1HD-ZIP family protein
Zosma6g02230.1HD-ZIP family protein
Zosma76g00750.1HD-ZIP family protein
Zosma20g00010.1HD-ZIP family protein
Zosma169g00180.1HD-ZIP family protein
Zosma199g00100.1HD-ZIP family protein
Zosma86g00400.1HD-ZIP family protein
Zosma52g00940.1HD-ZIP family protein
Zosma97g00520.1HD-ZIP family protein
Zosma75g00290.1HD-ZIP family protein
Zosma19g01250.1HD-ZIP family protein
Zosma57g00400.1HD-ZIP family protein
Zosma5g01920.1HD-ZIP family protein
Zosma189g00260.1HD-ZIP family protein
Zosma43g00170.1HD-ZIP family protein
Zosma77g00470.1HD-ZIP family protein
Zosma30g00880.1HD-ZIP family protein
Zosma123g00250.1HD-ZIP family protein
Zosma64g00040.1HD-ZIP family protein
Zosma29g01030.1HD-ZIP family protein
Zosma122g00770.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401