PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Zea mays
bHLH Family
Species TF ID Description
AC149829.2_FGP004bHLH family protein
AC177924.2_FGP001bHLH family protein
AC193786.3_FGP005bHLH family protein
AC198518.3_FGP005bHLH family protein
AC216731.3_FGP001bHLH family protein
AC233899.1_FGP002bHLH family protein
AC233960.1_FGP005bHLH family protein
GRMZM2G001930_P01bHLH family protein
GRMZM2G002627_P01bHLH family protein
GRMZM2G004356_P01bHLH family protein
GRMZM2G004732_P01bHLH family protein
GRMZM2G006631_P01bHLH family protein
GRMZM2G008691_P03bHLH family protein
GRMZM2G008898_P01bHLH family protein
GRMZM2G009478_P01bHLH family protein
GRMZM2G009478_P02bHLH family protein
GRMZM2G009478_P03bHLH family protein
GRMZM2G009478_P04bHLH family protein
GRMZM2G009478_P05bHLH family protein
GRMZM2G009478_P06bHLH family protein
GRMZM2G009837_P01bHLH family protein
GRMZM2G013688_P01bHLH family protein
GRMZM2G015666_P01bHLH family protein
GRMZM2G016039_P01bHLH family protein
GRMZM2G016039_P02bHLH family protein
GRMZM2G016039_P03bHLH family protein
GRMZM2G016756_P01bHLH family protein
GRMZM2G017145_P02bHLH family protein
GRMZM2G017145_P04bHLH family protein
GRMZM2G017145_P05bHLH family protein
GRMZM2G017349_P01bHLH family protein
GRMZM2G017586_P01bHLH family protein
GRMZM2G017586_P02bHLH family protein
GRMZM2G018472_P01bHLH family protein
GRMZM2G019806_P01bHLH family protein
GRMZM2G021276_P01bHLH family protein
GRMZM2G021276_P02bHLH family protein
GRMZM2G021276_P03bHLH family protein
GRMZM2G021276_P04bHLH family protein
GRMZM2G021276_P05bHLH family protein
GRMZM2G021276_P06bHLH family protein
GRMZM2G024530_P01bHLH family protein
GRMZM2G027068_P01bHLH family protein
GRMZM2G027563_P01bHLH family protein
GRMZM2G027563_P02bHLH family protein
GRMZM2G030744_P01bHLH family protein
GRMZM2G030744_P02bHLH family protein
GRMZM2G030744_P03bHLH family protein
GRMZM2G030762_P02bHLH family protein
GRMZM2G033356_P01bHLH family protein
GRMZM2G035156_P01bHLH family protein
GRMZM2G036092_P01bHLH family protein
GRMZM2G036554_P01bHLH family protein
GRMZM2G036554_P02bHLH family protein
GRMZM2G038479_P01bHLH family protein
GRMZM2G042101_P01bHLH family protein
GRMZM2G042893_P01bHLH family protein
GRMZM2G042893_P02bHLH family protein
GRMZM2G042893_P03bHLH family protein
GRMZM2G042893_P04bHLH family protein
GRMZM2G042893_P05bHLH family protein
GRMZM2G042895_P01bHLH family protein
GRMZM2G042920_P02bHLH family protein
GRMZM2G043854_P01bHLH family protein
GRMZM2G045109_P01bHLH family protein
GRMZM2G045431_P01bHLH family protein
GRMZM2G045883_P01bHLH family protein
GRMZM2G049229_P01bHLH family protein
GRMZM2G049686_P01bHLH family protein
GRMZM2G054564_P02bHLH family protein
GRMZM2G057260_P01bHLH family protein
GRMZM2G057413_P01bHLH family protein
GRMZM2G057413_P02bHLH family protein
GRMZM2G058451_P01bHLH family protein
GRMZM2G061906_P01bHLH family protein
GRMZM2G062541_P01bHLH family protein
GRMZM2G064638_P01bHLH family protein
GRMZM2G065374_P01bHLH family protein
GRMZM2G066057_P01bHLH family protein
GRMZM2G067654_P01bHLH family protein
GRMZM2G068604_P01bHLH family protein
GRMZM2G069408_P01bHLH family protein
GRMZM2G072376_P01bHLH family protein
GRMZM2G072820_P01bHLH family protein
GRMZM2G074438_P01bHLH family protein
GRMZM2G074501_P01bHLH family protein
GRMZM2G076636_P01bHLH family protein
GRMZM2G076636_P02bHLH family protein
GRMZM2G080054_P01bHLH family protein
GRMZM2G080054_P02bHLH family protein
GRMZM2G080054_P03bHLH family protein
GRMZM2G080168_P01bHLH family protein
GRMZM2G080168_P02bHLH family protein
GRMZM2G081816_P01bHLH family protein
GRMZM2G081816_P02bHLH family protein
GRMZM2G081816_P03bHLH family protein
GRMZM2G082343_P01bHLH family protein
GRMZM2G082586_P01bHLH family protein
GRMZM2G082630_P01bHLH family protein
GRMZM2G083504_P01bHLH family protein
GRMZM2G083504_P02bHLH family protein
GRMZM2G083504_P03bHLH family protein
GRMZM2G085467_P02bHLH family protein
GRMZM2G085751_P01bHLH family protein
GRMZM2G086474_P01bHLH family protein
GRMZM2G086474_P02bHLH family protein
GRMZM2G088443_P01bHLH family protein
GRMZM2G088443_P02bHLH family protein
GRMZM2G089501_P01bHLH family protein
GRMZM2G089501_P02bHLH family protein
GRMZM2G089501_P03bHLH family protein
GRMZM2G089501_P04bHLH family protein
GRMZM2G089501_P05bHLH family protein
GRMZM2G091003_P01bHLH family protein
GRMZM2G092091_P01bHLH family protein
GRMZM2G092091_P02bHLH family protein
GRMZM2G093744_P01bHLH family protein
GRMZM2G093744_P02bHLH family protein
GRMZM2G093744_P03bHLH family protein
GRMZM2G094892_P01bHLH family protein
GRMZM2G094892_P02bHLH family protein
GRMZM2G095899_P01bHLH family protein
GRMZM2G100313_P01bHLH family protein
GRMZM2G101350_P01bHLH family protein
GRMZM2G101350_P02bHLH family protein
GRMZM2G101350_P03bHLH family protein
GRMZM2G107276_P01bHLH family protein
GRMZM2G107560_P01bHLH family protein
GRMZM2G107672_P01bHLH family protein
GRMZM2G109605_P01bHLH family protein
GRMZM2G111146_P01bHLH family protein
GRMZM2G111146_P02bHLH family protein
GRMZM2G111146_P04bHLH family protein
GRMZM2G111666_P01bHLH family protein
GRMZM2G111666_P02bHLH family protein
GRMZM2G112629_P01bHLH family protein
GRMZM2G113257_P02bHLH family protein
GRMZM2G114444_P01bHLH family protein
GRMZM2G114444_P02bHLH family protein
GRMZM2G114873_P01bHLH family protein
GRMZM2G114873_P02bHLH family protein
GRMZM2G115960_P01bHLH family protein
GRMZM2G115960_P02bHLH family protein
GRMZM2G115960_P03bHLH family protein
GRMZM2G116785_P02bHLH family protein
GRMZM2G119823_P01bHLH family protein
GRMZM2G119823_P02bHLH family protein
GRMZM2G120021_P01bHLH family protein
GRMZM2G128807_P01bHLH family protein
GRMZM2G128807_P02bHLH family protein
GRMZM2G128807_P03bHLH family protein
GRMZM2G132550_P01bHLH family protein
GRMZM2G133675_P01bHLH family protein
GRMZM2G133675_P02bHLH family protein
GRMZM2G134735_P01bHLH family protein
GRMZM2G137358_P01bHLH family protein
GRMZM2G137374_P01bHLH family protein
GRMZM2G137380_P01bHLH family protein
GRMZM2G137426_P01bHLH family protein
GRMZM2G137541_P01bHLH family protein
GRMZM2G138454_P02bHLH family protein
GRMZM2G139372_P01bHLH family protein
GRMZM2G139372_P02bHLH family protein
GRMZM2G139372_P03bHLH family protein
GRMZM2G139372_P04bHLH family protein
GRMZM2G139372_P05bHLH family protein
GRMZM2G139372_P06bHLH family protein
GRMZM2G139372_P07bHLH family protein
GRMZM2G142932_P01bHLH family protein
GRMZM2G142932_P02bHLH family protein
GRMZM2G144275_P04bHLH family protein
GRMZM2G144275_P05bHLH family protein
GRMZM2G145146_P01bHLH family protein
GRMZM2G145579_P01bHLH family protein
GRMZM2G145579_P02bHLH family protein
GRMZM2G147685_P01bHLH family protein
GRMZM2G148723_P02bHLH family protein
GRMZM2G150327_P01bHLH family protein
GRMZM2G150729_P01bHLH family protein
GRMZM2G150729_P02bHLH family protein
GRMZM2G153454_P01bHLH family protein
GRMZM2G153454_P02bHLH family protein
GRMZM2G154029_P01bHLH family protein
GRMZM2G154029_P03bHLH family protein
GRMZM2G155043_P01bHLH family protein
GRMZM2G155217_P01bHLH family protein
GRMZM2G155762_P01bHLH family protein
GRMZM2G159456_P01bHLH family protein
GRMZM2G159937_P01bHLH family protein
GRMZM2G162382_P01bHLH family protein
GRMZM2G162382_P02bHLH family protein
GRMZM2G162450_P01bHLH family protein
GRMZM2G163233_P01bHLH family protein
GRMZM2G163233_P02bHLH family protein
GRMZM2G163975_P01bHLH family protein
GRMZM2G164341_P01bHLH family protein
GRMZM2G165042_P01bHLH family protein
GRMZM2G165090_P01bHLH family protein
GRMZM2G165188_P01bHLH family protein
GRMZM2G166642_P01bHLH family protein
GRMZM2G166642_P02bHLH family protein
GRMZM2G166642_P03bHLH family protein
GRMZM2G169947_P01bHLH family protein
GRMZM2G170559_P01bHLH family protein
GRMZM2G171464_P01bHLH family protein
GRMZM2G171818_P01bHLH family protein
GRMZM2G171818_P02bHLH family protein
GRMZM2G172297_P01bHLH family protein
GRMZM2G172795_P01bHLH family protein
GRMZM2G173372_P01bHLH family protein
GRMZM2G173372_P02bHLH family protein
GRMZM2G173521_P01bHLH family protein
GRMZM2G173534_P01bHLH family protein
GRMZM2G173534_P02bHLH family protein
GRMZM2G173862_P01bHLH family protein
GRMZM2G175480_P01bHLH family protein
GRMZM2G175955_P01bHLH family protein
GRMZM2G176141_P01bHLH family protein
GRMZM2G176289_P01bHLH family protein
GRMZM2G176289_P02bHLH family protein
GRMZM2G176289_P03bHLH family protein
GRMZM2G178182_P01bHLH family protein
GRMZM2G178182_P02bHLH family protein
GRMZM2G180406_P01bHLH family protein
GRMZM2G180406_P03bHLH family protein
GRMZM2G180452_P01bHLH family protein
GRMZM2G180452_P02bHLH family protein
GRMZM2G180452_P03bHLH family protein
GRMZM2G180452_P04bHLH family protein
GRMZM2G180452_P05bHLH family protein
GRMZM2G180452_P06bHLH family protein
GRMZM2G301089_P01bHLH family protein
GRMZM2G301089_P02bHLH family protein
GRMZM2G303463_P01bHLH family protein
GRMZM2G313058_P01bHLH family protein
GRMZM2G313756_P01bHLH family protein
GRMZM2G314882_P01bHLH family protein
GRMZM2G314882_P03bHLH family protein
GRMZM2G314882_P04bHLH family protein
GRMZM2G316758_P01bHLH family protein
GRMZM2G317317_P01bHLH family protein
GRMZM2G317450_P01bHLH family protein
GRMZM2G317450_P02bHLH family protein
GRMZM2G317450_P03bHLH family protein
GRMZM2G333582_P01bHLH family protein
GRMZM2G340177_P01bHLH family protein
GRMZM2G350165_P01bHLH family protein
GRMZM2G350165_P02bHLH family protein
GRMZM2G350312_P01bHLH family protein
GRMZM2G350312_P02bHLH family protein
GRMZM2G350312_P03bHLH family protein
GRMZM2G350312_P04bHLH family protein
GRMZM2G354618_P01bHLH family protein
GRMZM2G355469_P01bHLH family protein
GRMZM2G369629_P01bHLH family protein
GRMZM2G369629_P02bHLH family protein
GRMZM2G378653_P01bHLH family protein
GRMZM2G378653_P02bHLH family protein
GRMZM2G383841_P01bHLH family protein
GRMZM2G385543_P01bHLH family protein
GRMZM2G387528_P02bHLH family protein
GRMZM2G389567_P01bHLH family protein
GRMZM2G395549_P01bHLH family protein
GRMZM2G397518_P01bHLH family protein
GRMZM2G397755_P01bHLH family protein
GRMZM2G407119_P01bHLH family protein
GRMZM2G407119_P02bHLH family protein
GRMZM2G412430_P02bHLH family protein
GRMZM2G412430_P03bHLH family protein
GRMZM2G414252_P01bHLH family protein
GRMZM2G417164_P01bHLH family protein
GRMZM2G417597_P01bHLH family protein
GRMZM2G435015_P01bHLH family protein
GRMZM2G437481_P01bHLH family protein
GRMZM2G440529_P01bHLH family protein
GRMZM2G452996_P01bHLH family protein
GRMZM2G454022_P01bHLH family protein
GRMZM2G463133_P01bHLH family protein
GRMZM2G471635_P01bHLH family protein
GRMZM2G472671_P01bHLH family protein
GRMZM2G475289_P01bHLH family protein
GRMZM2G475289_P02bHLH family protein
GRMZM2G481280_P01bHLH family protein
GRMZM2G526668_P02bHLH family protein
GRMZM5G812883_P01bHLH family protein
GRMZM5G817854_P01bHLH family protein
GRMZM5G818643_P01bHLH family protein
GRMZM5G818643_P02bHLH family protein
GRMZM5G818776_P01bHLH family protein
GRMZM5G822829_P01bHLH family protein
GRMZM5G822829_P03bHLH family protein
GRMZM5G828396_P01bHLH family protein
GRMZM5G828396_P02bHLH family protein
GRMZM5G839518_P02bHLH family protein
GRMZM5G839518_P03bHLH family protein
GRMZM5G849600_P01bHLH family protein
GRMZM5G856837_P01bHLH family protein
GRMZM5G863198_P01bHLH family protein
GRMZM5G865967_P01bHLH family protein
GRMZM5G879527_P01bHLH family protein
GRMZM5G879527_P02bHLH family protein
GRMZM5G879527_P03bHLH family protein
GRMZM5G879527_P04bHLH family protein
GRMZM5G882527_P02bHLH family protein
GRMZM5G882527_P03bHLH family protein
GRMZM5G882527_P04bHLH family protein
GRMZM5G896413_P01bHLH family protein
GRMZM5G899865_P01bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250