PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Zea mays
HD-ZIP Family
Species TF ID Description
GRMZM2G041127_P02HD-ZIP family protein
GRMZM2G056600_P01HD-ZIP family protein
GRMZM2G122076_P02HD-ZIP family protein
GRMZM2G021339_P02HD-ZIP family protein
GRMZM2G021339_P03HD-ZIP family protein
GRMZM2G041127_P01HD-ZIP family protein
GRMZM2G041127_P03HD-ZIP family protein
GRMZM2G041127_P04HD-ZIP family protein
GRMZM2G021339_P01HD-ZIP family protein
GRMZM2G122076_P01HD-ZIP family protein
GRMZM2G003304_P01HD-ZIP family protein
GRMZM2G044752_P03HD-ZIP family protein
GRMZM2G044752_P01HD-ZIP family protein
GRMZM5G803812_P01HD-ZIP family protein
GRMZM2G097349_P01HD-ZIP family protein
GRMZM2G142962_P03HD-ZIP family protein
GRMZM2G139963_P01HD-ZIP family protein
GRMZM2G142962_P02HD-ZIP family protein
GRMZM2G127537_P01HD-ZIP family protein
GRMZM2G148074_P01HD-ZIP family protein
GRMZM2G106276_P01HD-ZIP family protein
GRMZM2G131476_P01HD-ZIP family protein
GRMZM2G119999_P02HD-ZIP family protein
GRMZM2G134260_P01HD-ZIP family protein
GRMZM2G119999_P01HD-ZIP family protein
GRMZM2G178741_P02HD-ZIP family protein
GRMZM2G126808_P03HD-ZIP family protein
GRMZM2G132367_P01HD-ZIP family protein
GRMZM2G132367_P02HD-ZIP family protein
GRMZM2G351330_P01HD-ZIP family protein
GRMZM2G041462_P01HD-ZIP family protein
GRMZM2G068672_P01HD-ZIP family protein
GRMZM2G105834_P01HD-ZIP family protein
GRMZM2G047715_P01HD-ZIP family protein
GRMZM2G117164_P01HD-ZIP family protein
GRMZM2G396527_P01HD-ZIP family protein
GRMZM2G126239_P01HD-ZIP family protein
GRMZM2G178741_P01HD-ZIP family protein
GRMZM2G034113_P01HD-ZIP family protein
GRMZM2G366130_P01HD-ZIP family protein
AC233899.1_FGP004HD-ZIP family protein
GRMZM2G126808_P04HD-ZIP family protein
GRMZM2G126808_P02HD-ZIP family protein
GRMZM2G062244_P01HD-ZIP family protein
GRMZM2G307397_P01HD-ZIP family protein
GRMZM2G005624_P01HD-ZIP family protein
GRMZM2G002915_P02HD-ZIP family protein
GRMZM2G002915_P01HD-ZIP family protein
GRMZM2G477415_P01HD-ZIP family protein
GRMZM2G166041_P01HD-ZIP family protein
GRMZM2G307400_P01HD-ZIP family protein
GRMZM5G830671_P01HD-ZIP family protein
GRMZM2G131476_P02HD-ZIP family protein
GRMZM2G134260_P02HD-ZIP family protein
GRMZM2G044752_P05HD-ZIP family protein
GRMZM2G142962_P01HD-ZIP family protein
GRMZM2G104204_P01HD-ZIP family protein
GRMZM2G122897_P01HD-ZIP family protein
GRMZM2G130442_P02HD-ZIP family protein
GRMZM2G130442_P01HD-ZIP family protein
GRMZM2G004957_P01HD-ZIP family protein
GRMZM2G004957_P02HD-ZIP family protein
GRMZM2G001289_P02HD-ZIP family protein
GRMZM2G001289_P01HD-ZIP family protein
GRMZM2G026643_P01HD-ZIP family protein
GRMZM2G026643_P02HD-ZIP family protein
GRMZM2G118063_P03HD-ZIP family protein
GRMZM2G118063_P01HD-ZIP family protein
GRMZM2G118063_P02HD-ZIP family protein
GRMZM2G116658_P01HD-ZIP family protein
AC187157.4_FGP005HD-ZIP family protein
GRMZM2G126646_P01HD-ZIP family protein
GRMZM2G003509_P01HD-ZIP family protein
GRMZM2G145690_P02HD-ZIP family protein
GRMZM2G145690_P01HD-ZIP family protein
GRMZM2G042250_P04HD-ZIP family protein
GRMZM2G042250_P01HD-ZIP family protein
GRMZM2G042250_P02HD-ZIP family protein
GRMZM2G042250_P03HD-ZIP family protein
GRMZM2G178102_P01HD-ZIP family protein
GRMZM2G109987_P04HD-ZIP family protein
GRMZM2G109987_P01HD-ZIP family protein
GRMZM2G109987_P03HD-ZIP family protein
GRMZM2G109987_P02HD-ZIP family protein
GRMZM2G109987_P05HD-ZIP family protein
GRMZM2G469551_P02HD-ZIP family protein
AC235534.1_FGP007HD-ZIP family protein
GRMZM2G469551_P01HD-ZIP family protein
GRMZM2G004334_P01HD-ZIP family protein
GRMZM2G123140_P04HD-ZIP family protein
GRMZM2G123140_P02HD-ZIP family protein
GRMZM2G123140_P05HD-ZIP family protein
GRMZM2G123140_P01HD-ZIP family protein
GRMZM2G123140_P03HD-ZIP family protein
GRMZM2G438260_P01HD-ZIP family protein
GRMZM2G060444_P01HD-ZIP family protein
GRMZM2G386276_P01HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401