PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Ziziphus jujuba
bHLH Family
Species TF ID Description
XP_015865728.1bHLH family protein
XP_015866259.1bHLH family protein
XP_015866729.1bHLH family protein
XP_015866737.1bHLH family protein
XP_015866794.1bHLH family protein
XP_015866969.1bHLH family protein
XP_015867026.1bHLH family protein
XP_015867031.1bHLH family protein
XP_015867132.1bHLH family protein
XP_015867675.1bHLH family protein
XP_015868192.1bHLH family protein
XP_015868749.1bHLH family protein
XP_015868957.1bHLH family protein
XP_015868969.1bHLH family protein
XP_015868974.1bHLH family protein
XP_015868975.1bHLH family protein
XP_015868985.1bHLH family protein
XP_015868990.1bHLH family protein
XP_015869190.1bHLH family protein
XP_015869191.1bHLH family protein
XP_015869842.1bHLH family protein
XP_015869909.1bHLH family protein
XP_015869917.1bHLH family protein
XP_015869924.1bHLH family protein
XP_015869933.1bHLH family protein
XP_015870030.1bHLH family protein
XP_015870213.1bHLH family protein
XP_015871076.1bHLH family protein
XP_015871249.1bHLH family protein
XP_015871359.1bHLH family protein
XP_015871816.1bHLH family protein
XP_015872823.1bHLH family protein
XP_015874491.1bHLH family protein
XP_015874808.1bHLH family protein
XP_015874809.1bHLH family protein
XP_015875423.1bHLH family protein
XP_015875424.1bHLH family protein
XP_015875928.1bHLH family protein
XP_015875929.1bHLH family protein
XP_015876019.1bHLH family protein
XP_015876980.1bHLH family protein
XP_015876981.1bHLH family protein
XP_015876982.1bHLH family protein
XP_015876983.1bHLH family protein
XP_015876984.1bHLH family protein
XP_015876985.1bHLH family protein
XP_015876987.1bHLH family protein
XP_015877971.1bHLH family protein
XP_015877981.1bHLH family protein
XP_015877982.1bHLH family protein
XP_015877984.1bHLH family protein
XP_015878205.1bHLH family protein
XP_015879350.1bHLH family protein
XP_015880191.1bHLH family protein
XP_015880243.1bHLH family protein
XP_015880244.1bHLH family protein
XP_015880600.1bHLH family protein
XP_015880601.1bHLH family protein
XP_015881066.1bHLH family protein
XP_015881068.1bHLH family protein
XP_015881324.1bHLH family protein
XP_015881343.1bHLH family protein
XP_015882192.1bHLH family protein
XP_015882267.1bHLH family protein
XP_015882268.1bHLH family protein
XP_015882629.1bHLH family protein
XP_015882712.1bHLH family protein
XP_015882713.1bHLH family protein
XP_015882980.1bHLH family protein
XP_015883254.1bHLH family protein
XP_015883255.1bHLH family protein
XP_015883375.1bHLH family protein
XP_015883376.1bHLH family protein
XP_015883400.1bHLH family protein
XP_015883513.1bHLH family protein
XP_015883514.1bHLH family protein
XP_015883523.1bHLH family protein
XP_015884278.1bHLH family protein
XP_015884317.1bHLH family protein
XP_015884335.1bHLH family protein
XP_015884336.1bHLH family protein
XP_015884337.1bHLH family protein
XP_015884937.1bHLH family protein
XP_015885026.1bHLH family protein
XP_015885132.1bHLH family protein
XP_015885133.1bHLH family protein
XP_015885134.1bHLH family protein
XP_015885249.1bHLH family protein
XP_015885269.1bHLH family protein
XP_015885861.1bHLH family protein
XP_015885983.1bHLH family protein
XP_015885984.1bHLH family protein
XP_015886306.1bHLH family protein
XP_015886558.1bHLH family protein
XP_015886777.1bHLH family protein
XP_015886785.1bHLH family protein
XP_015887121.1bHLH family protein
XP_015887122.1bHLH family protein
XP_015887123.1bHLH family protein
XP_015887489.1bHLH family protein
XP_015887823.1bHLH family protein
XP_015887824.1bHLH family protein
XP_015887825.1bHLH family protein
XP_015887981.1bHLH family protein
XP_015888270.1bHLH family protein
XP_015888410.1bHLH family protein
XP_015888651.1bHLH family protein
XP_015888663.1bHLH family protein
XP_015888724.1bHLH family protein
XP_015888894.1bHLH family protein
XP_015888932.1bHLH family protein
XP_015888933.1bHLH family protein
XP_015888934.1bHLH family protein
XP_015889249.1bHLH family protein
XP_015889419.1bHLH family protein
XP_015889640.1bHLH family protein
XP_015889816.1bHLH family protein
XP_015889817.1bHLH family protein
XP_015889818.1bHLH family protein
XP_015889819.1bHLH family protein
XP_015889872.1bHLH family protein
XP_015889971.1bHLH family protein
XP_015890138.1bHLH family protein
XP_015890377.1bHLH family protein
XP_015890378.1bHLH family protein
XP_015890379.1bHLH family protein
XP_015890380.1bHLH family protein
XP_015890448.1bHLH family protein
XP_015890522.1bHLH family protein
XP_015890729.1bHLH family protein
XP_015890730.1bHLH family protein
XP_015890731.1bHLH family protein
XP_015891196.1bHLH family protein
XP_015891470.1bHLH family protein
XP_015891480.1bHLH family protein
XP_015891504.1bHLH family protein
XP_015891505.1bHLH family protein
XP_015891593.1bHLH family protein
XP_015891828.1bHLH family protein
XP_015892114.1bHLH family protein
XP_015892261.1bHLH family protein
XP_015892262.1bHLH family protein
XP_015892293.1bHLH family protein
XP_015892516.1bHLH family protein
XP_015892614.1bHLH family protein
XP_015892818.1bHLH family protein
XP_015892819.1bHLH family protein
XP_015893146.1bHLH family protein
XP_015893295.1bHLH family protein
XP_015893436.1bHLH family protein
XP_015894738.1bHLH family protein
XP_015894924.1bHLH family protein
XP_015895230.1bHLH family protein
XP_015895269.1bHLH family protein
XP_015895330.1bHLH family protein
XP_015895533.1bHLH family protein
XP_015895685.1bHLH family protein
XP_015895915.1bHLH family protein
XP_015896035.1bHLH family protein
XP_015896324.1bHLH family protein
XP_015896335.1bHLH family protein
XP_015896336.1bHLH family protein
XP_015896887.1bHLH family protein
XP_015896923.1bHLH family protein
XP_015897521.1bHLH family protein
XP_015898008.1bHLH family protein
XP_015898010.1bHLH family protein
XP_015898140.1bHLH family protein
XP_015898241.1bHLH family protein
XP_015898395.1bHLH family protein
XP_015899023.1bHLH family protein
XP_015899024.1bHLH family protein
XP_015899049.1bHLH family protein
XP_015899050.1bHLH family protein
XP_015900346.1bHLH family protein
XP_015900464.1bHLH family protein
XP_015900575.1bHLH family protein
XP_015900576.1bHLH family protein
XP_015900980.1bHLH family protein
XP_015901482.1bHLH family protein
XP_015901602.1bHLH family protein
XP_015901603.1bHLH family protein
XP_015902282.1bHLH family protein
XP_015902991.1bHLH family protein
XP_015902992.1bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250