PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Vigna unguiculata
HD-ZIP Family
Species TF ID Description
Vun002668HD-ZIP family protein
Vun002989HD-ZIP family protein
Vun001992HD-ZIP family protein
Vun008959HD-ZIP family protein
Vun007979HD-ZIP family protein
Vun000257HD-ZIP family protein
Vun005872HD-ZIP family protein
Vun002040HD-ZIP family protein
Vun001401HD-ZIP family protein
Vun002683HD-ZIP family protein
Vun004620HD-ZIP family protein
Vun008880HD-ZIP family protein
Vun003852HD-ZIP family protein
Vun004812HD-ZIP family protein
Vun005544HD-ZIP family protein
Vun011002HD-ZIP family protein
Vun008257HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401