PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Vigna radiata
bHLH Family
Species TF ID Description
Vradi0007s01280.1bHLH family protein
Vradi0023s00880.1bHLH family protein
Vradi0051s00490.1bHLH family protein
Vradi0073s00030.1bHLH family protein
Vradi0083s00280.1bHLH family protein
Vradi0091s00210.1bHLH family protein
Vradi0149s00030.1bHLH family protein
Vradi0154s00030.1bHLH family protein
Vradi0169s00280.1bHLH family protein
Vradi0171s00110.1bHLH family protein
Vradi0179s00420.1bHLH family protein
Vradi0183s00260.1bHLH family protein
Vradi0185s00010.1bHLH family protein
Vradi0189s00090.1bHLH family protein
Vradi01g01940.1bHLH family protein
Vradi01g03830.1bHLH family protein
Vradi01g04660.1bHLH family protein
Vradi01g06980.1bHLH family protein
Vradi01g06990.1bHLH family protein
Vradi01g11070.1bHLH family protein
Vradi0221s00080.1bHLH family protein
Vradi0253s00080.1bHLH family protein
Vradi0276s00010.1bHLH family protein
Vradi0290s00060.1bHLH family protein
Vradi02g00210.1bHLH family protein
Vradi02g02130.1bHLH family protein
Vradi02g04340.1bHLH family protein
Vradi02g09500.1bHLH family protein
Vradi02g14260.1bHLH family protein
Vradi0307s00130.1bHLH family protein
Vradi0310s00020.1bHLH family protein
Vradi0339s00010.1bHLH family protein
Vradi0347s00090.1bHLH family protein
Vradi0367s00030.1bHLH family protein
Vradi03g00740.1bHLH family protein
Vradi03g01220.1bHLH family protein
Vradi03g01510.1bHLH family protein
Vradi03g01980.1bHLH family protein
Vradi03g02010.1bHLH family protein
Vradi03g02820.1bHLH family protein
Vradi03g06970.1bHLH family protein
Vradi03g07220.1bHLH family protein
Vradi03g08040.1bHLH family protein
Vradi03g09220.1bHLH family protein
Vradi03g09270.1bHLH family protein
Vradi03g10130.1bHLH family protein
Vradi0441s00060.1bHLH family protein
Vradi0447s00010.1bHLH family protein
Vradi04g00980.1bHLH family protein
Vradi04g01350.1bHLH family protein
Vradi04g03150.1bHLH family protein
Vradi04g04730.1bHLH family protein
Vradi04g05840.1bHLH family protein
Vradi04g07240.1bHLH family protein
Vradi04g07860.1bHLH family protein
Vradi04g07870.1bHLH family protein
Vradi04g08690.1bHLH family protein
Vradi04g09650.1bHLH family protein
Vradi0536s00010.1bHLH family protein
Vradi05g02660.1bHLH family protein
Vradi05g03060.1bHLH family protein
Vradi05g04030.1bHLH family protein
Vradi05g04860.1bHLH family protein
Vradi05g07430.1bHLH family protein
Vradi05g08260.1bHLH family protein
Vradi05g12650.1bHLH family protein
Vradi05g14840.1bHLH family protein
Vradi05g15880.1bHLH family protein
Vradi05g16320.1bHLH family protein
Vradi05g16330.1bHLH family protein
Vradi05g17920.1bHLH family protein
Vradi05g20460.1bHLH family protein
Vradi05g20830.1bHLH family protein
Vradi05g22790.1bHLH family protein
Vradi05g22830.1bHLH family protein
Vradi06g02520.1bHLH family protein
Vradi06g04380.1bHLH family protein
Vradi06g05400.1bHLH family protein
Vradi06g08080.1bHLH family protein
Vradi06g09990.1bHLH family protein
Vradi06g14400.1bHLH family protein
Vradi06g14710.1bHLH family protein
Vradi06g15060.1bHLH family protein
Vradi06g16580.1bHLH family protein
Vradi07g00790.1bHLH family protein
Vradi07g01160.1bHLH family protein
Vradi07g02980.1bHLH family protein
Vradi07g03400.1bHLH family protein
Vradi07g03660.1bHLH family protein
Vradi07g04070.1bHLH family protein
Vradi07g05320.1bHLH family protein
Vradi07g06060.1bHLH family protein
Vradi07g07600.1bHLH family protein
Vradi07g09210.1bHLH family protein
Vradi07g10580.1bHLH family protein
Vradi07g10630.1bHLH family protein
Vradi07g11610.1bHLH family protein
Vradi07g11630.1bHLH family protein
Vradi07g14230.1bHLH family protein
Vradi07g14850.1bHLH family protein
Vradi07g15540.1bHLH family protein
Vradi07g17780.1bHLH family protein
Vradi07g21250.1bHLH family protein
Vradi07g22620.1bHLH family protein
Vradi07g25560.1bHLH family protein
Vradi07g27750.1bHLH family protein
Vradi07g29900.1bHLH family protein
Vradi07g30610.1bHLH family protein
Vradi08g00060.1bHLH family protein
Vradi08g02110.1bHLH family protein
Vradi08g02140.1bHLH family protein
Vradi08g03420.1bHLH family protein
Vradi08g08580.1bHLH family protein
Vradi08g08730.1bHLH family protein
Vradi08g08860.1bHLH family protein
Vradi08g09530.1bHLH family protein
Vradi08g09610.1bHLH family protein
Vradi08g11300.1bHLH family protein
Vradi08g11790.1bHLH family protein
Vradi08g13260.1bHLH family protein
Vradi08g14110.1bHLH family protein
Vradi08g16460.1bHLH family protein
Vradi08g16550.1bHLH family protein
Vradi08g19280.1bHLH family protein
Vradi08g19290.1bHLH family protein
Vradi08g20010.1bHLH family protein
Vradi08g20310.1bHLH family protein
Vradi08g21970.1bHLH family protein
Vradi08g23250.1bHLH family protein
Vradi09g00080.1bHLH family protein
Vradi09g01350.1bHLH family protein
Vradi09g01800.1bHLH family protein
Vradi09g06080.1bHLH family protein
Vradi09g06090.1bHLH family protein
Vradi09g06100.1bHLH family protein
Vradi09g06110.1bHLH family protein
Vradi09g06160.1bHLH family protein
Vradi09g06460.1bHLH family protein
Vradi09g06910.1bHLH family protein
Vradi10g01970.1bHLH family protein
Vradi10g05010.1bHLH family protein
Vradi10g08350.1bHLH family protein
Vradi10g11920.1bHLH family protein
Vradi11g03750.1bHLH family protein
Vradi11g04660.1bHLH family protein
Vradi11g04710.1bHLH family protein
Vradi11g08900.1bHLH family protein
Vradi11g09040.1bHLH family protein
Vradi11g09470.1bHLH family protein
Vradi11g11830.1bHLH family protein
Vradi11g12000.1bHLH family protein
Vradi11g12270.1bHLH family protein
Vradi11g12460.1bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250