PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Vigna angularis
M-type_MADS Family
Species TF ID Description
Vang0002ss02280.1M-type_MADS family protein
Vang0013ss00230.1M-type_MADS family protein
Vang0013ss00230.2M-type_MADS family protein
Vang0032ss00720.1M-type_MADS family protein
Vang0053ss00150.1M-type_MADS family protein
Vang0062ss00080.1M-type_MADS family protein
Vang0064ss00130.1M-type_MADS family protein
Vang0064ss00150.1M-type_MADS family protein
Vang0248s00130.1M-type_MADS family protein
Vang0268s00450.1M-type_MADS family protein
Vang02g07170.1M-type_MADS family protein
Vang02g07170.2M-type_MADS family protein
Vang02g11040.1M-type_MADS family protein
Vang02g11040.2M-type_MADS family protein
Vang0318s00010.1M-type_MADS family protein
Vang0361s00090.1M-type_MADS family protein
Vang03g12440.1M-type_MADS family protein
Vang03g12440.2M-type_MADS family protein
Vang03g12450.1M-type_MADS family protein
Vang03g12460.1M-type_MADS family protein
Vang03g12490.1M-type_MADS family protein
Vang03g12490.2M-type_MADS family protein
Vang03g12500.1M-type_MADS family protein
Vang03g12500.2M-type_MADS family protein
Vang03g17860.1M-type_MADS family protein
Vang04g05940.1M-type_MADS family protein
Vang0685s00030.1M-type_MADS family protein
Vang06g02580.1M-type_MADS family protein
Vang06g02640.1M-type_MADS family protein
Vang06g02680.1M-type_MADS family protein
Vang06g19320.1M-type_MADS family protein
Vang06g24910.1M-type_MADS family protein
Vang06g24910.2M-type_MADS family protein
Vang06g24910.3M-type_MADS family protein
Vang06g24910.4M-type_MADS family protein
Vang0717s00040.1M-type_MADS family protein
Vang0717s00040.2M-type_MADS family protein
Vang07g08110.1M-type_MADS family protein
Vang08g03740.1M-type_MADS family protein
Vang08g04110.1M-type_MADS family protein
Vang0913s00010.1M-type_MADS family protein
Vang09g00860.1M-type_MADS family protein
Vang09g05450.1M-type_MADS family protein
Vang10g02270.1M-type_MADS family protein
Vang10g02310.1M-type_MADS family protein
Vang11g06830.1M-type_MADS family protein
Vang11g06960.1M-type_MADS family protein
Vang11g11490.1M-type_MADS family protein
Vang11g15490.1M-type_MADS family protein
Vang11g15490.2M-type_MADS family protein
Vang11g16990.1M-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513