PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Trifolium pratense
M-type_MADS Family
Species TF ID Description
Tp57577_TGAC_v2_mRNA11271M-type_MADS family protein
Tp57577_TGAC_v2_mRNA11384M-type_MADS family protein
Tp57577_TGAC_v2_mRNA12155M-type_MADS family protein
Tp57577_TGAC_v2_mRNA12286M-type_MADS family protein
Tp57577_TGAC_v2_mRNA12294M-type_MADS family protein
Tp57577_TGAC_v2_mRNA12311M-type_MADS family protein
Tp57577_TGAC_v2_mRNA12316M-type_MADS family protein
Tp57577_TGAC_v2_mRNA12334M-type_MADS family protein
Tp57577_TGAC_v2_mRNA12860M-type_MADS family protein
Tp57577_TGAC_v2_mRNA14081M-type_MADS family protein
Tp57577_TGAC_v2_mRNA1462M-type_MADS family protein
Tp57577_TGAC_v2_mRNA15032M-type_MADS family protein
Tp57577_TGAC_v2_mRNA15177M-type_MADS family protein
Tp57577_TGAC_v2_mRNA15248M-type_MADS family protein
Tp57577_TGAC_v2_mRNA16398M-type_MADS family protein
Tp57577_TGAC_v2_mRNA16407M-type_MADS family protein
Tp57577_TGAC_v2_mRNA16639M-type_MADS family protein
Tp57577_TGAC_v2_mRNA17350M-type_MADS family protein
Tp57577_TGAC_v2_mRNA17575M-type_MADS family protein
Tp57577_TGAC_v2_mRNA1803M-type_MADS family protein
Tp57577_TGAC_v2_mRNA18191M-type_MADS family protein
Tp57577_TGAC_v2_mRNA19010M-type_MADS family protein
Tp57577_TGAC_v2_mRNA1915M-type_MADS family protein
Tp57577_TGAC_v2_mRNA1917M-type_MADS family protein
Tp57577_TGAC_v2_mRNA19730M-type_MADS family protein
Tp57577_TGAC_v2_mRNA2020M-type_MADS family protein
Tp57577_TGAC_v2_mRNA20359M-type_MADS family protein
Tp57577_TGAC_v2_mRNA2039M-type_MADS family protein
Tp57577_TGAC_v2_mRNA21233M-type_MADS family protein
Tp57577_TGAC_v2_mRNA21561M-type_MADS family protein
Tp57577_TGAC_v2_mRNA21737M-type_MADS family protein
Tp57577_TGAC_v2_mRNA21862M-type_MADS family protein
Tp57577_TGAC_v2_mRNA22346M-type_MADS family protein
Tp57577_TGAC_v2_mRNA22774M-type_MADS family protein
Tp57577_TGAC_v2_mRNA23761M-type_MADS family protein
Tp57577_TGAC_v2_mRNA23997M-type_MADS family protein
Tp57577_TGAC_v2_mRNA24190M-type_MADS family protein
Tp57577_TGAC_v2_mRNA24207M-type_MADS family protein
Tp57577_TGAC_v2_mRNA24508M-type_MADS family protein
Tp57577_TGAC_v2_mRNA24833M-type_MADS family protein
Tp57577_TGAC_v2_mRNA25139M-type_MADS family protein
Tp57577_TGAC_v2_mRNA25233M-type_MADS family protein
Tp57577_TGAC_v2_mRNA25300M-type_MADS family protein
Tp57577_TGAC_v2_mRNA25304M-type_MADS family protein
Tp57577_TGAC_v2_mRNA25310M-type_MADS family protein
Tp57577_TGAC_v2_mRNA26430M-type_MADS family protein
Tp57577_TGAC_v2_mRNA27308M-type_MADS family protein
Tp57577_TGAC_v2_mRNA27652M-type_MADS family protein
Tp57577_TGAC_v2_mRNA27961M-type_MADS family protein
Tp57577_TGAC_v2_mRNA28322M-type_MADS family protein
Tp57577_TGAC_v2_mRNA28663M-type_MADS family protein
Tp57577_TGAC_v2_mRNA29038M-type_MADS family protein
Tp57577_TGAC_v2_mRNA29403M-type_MADS family protein
Tp57577_TGAC_v2_mRNA29711M-type_MADS family protein
Tp57577_TGAC_v2_mRNA29943M-type_MADS family protein
Tp57577_TGAC_v2_mRNA30803M-type_MADS family protein
Tp57577_TGAC_v2_mRNA315M-type_MADS family protein
Tp57577_TGAC_v2_mRNA32495M-type_MADS family protein
Tp57577_TGAC_v2_mRNA32568M-type_MADS family protein
Tp57577_TGAC_v2_mRNA32921M-type_MADS family protein
Tp57577_TGAC_v2_mRNA33537M-type_MADS family protein
Tp57577_TGAC_v2_mRNA35281M-type_MADS family protein
Tp57577_TGAC_v2_mRNA35734M-type_MADS family protein
Tp57577_TGAC_v2_mRNA36086M-type_MADS family protein
Tp57577_TGAC_v2_mRNA36392M-type_MADS family protein
Tp57577_TGAC_v2_mRNA36950M-type_MADS family protein
Tp57577_TGAC_v2_mRNA38349M-type_MADS family protein
Tp57577_TGAC_v2_mRNA39058M-type_MADS family protein
Tp57577_TGAC_v2_mRNA39095M-type_MADS family protein
Tp57577_TGAC_v2_mRNA39141M-type_MADS family protein
Tp57577_TGAC_v2_mRNA3977M-type_MADS family protein
Tp57577_TGAC_v2_mRNA39807M-type_MADS family protein
Tp57577_TGAC_v2_mRNA3984M-type_MADS family protein
Tp57577_TGAC_v2_mRNA40586M-type_MADS family protein
Tp57577_TGAC_v2_mRNA41069M-type_MADS family protein
Tp57577_TGAC_v2_mRNA4734M-type_MADS family protein
Tp57577_TGAC_v2_mRNA5032M-type_MADS family protein
Tp57577_TGAC_v2_mRNA547M-type_MADS family protein
Tp57577_TGAC_v2_mRNA548M-type_MADS family protein
Tp57577_TGAC_v2_mRNA7596M-type_MADS family protein
Tp57577_TGAC_v2_mRNA7829M-type_MADS family protein
Tp57577_TGAC_v2_mRNA7859M-type_MADS family protein
Tp57577_TGAC_v2_mRNA8745M-type_MADS family protein
Tp57577_TGAC_v2_mRNA9029M-type_MADS family protein
Tp57577_TGAC_v2_mRNA9359M-type_MADS family protein
Tp57577_TGAC_v2_mRNA9557M-type_MADS family protein
Tp57577_TGAC_v2_mRNA9810M-type_MADS family protein
Tp57577_TGAC_v2_mRNA9914M-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513