PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Thellungiella parvula
M-type_MADS Family
Species TF ID Description
Tp1g15440M-type_MADS family protein
Tp1g16760M-type_MADS family protein
Tp1g20080M-type_MADS family protein
Tp1g25830M-type_MADS family protein
Tp1g35160M-type_MADS family protein
Tp1g36460M-type_MADS family protein
Tp2g03710M-type_MADS family protein
Tp2g03770M-type_MADS family protein
Tp2g05320M-type_MADS family protein
Tp2g11160M-type_MADS family protein
Tp2g11170M-type_MADS family protein
Tp2g14060M-type_MADS family protein
Tp2g21270M-type_MADS family protein
Tp2g21290M-type_MADS family protein
Tp2g28140M-type_MADS family protein
Tp2g28150M-type_MADS family protein
Tp2g28440M-type_MADS family protein
Tp3g03070M-type_MADS family protein
Tp3g04730M-type_MADS family protein
Tp3g04740M-type_MADS family protein
Tp3g04750M-type_MADS family protein
Tp3g05620M-type_MADS family protein
Tp3g10030M-type_MADS family protein
Tp3g10040M-type_MADS family protein
Tp3g16720M-type_MADS family protein
Tp3g17710M-type_MADS family protein
Tp3g24480M-type_MADS family protein
Tp4g03860M-type_MADS family protein
Tp4g06780M-type_MADS family protein
Tp4g11470M-type_MADS family protein
Tp4g16710M-type_MADS family protein
Tp5g22080M-type_MADS family protein
Tp5g22450M-type_MADS family protein
Tp5g27440M-type_MADS family protein
Tp5g29630M-type_MADS family protein
Tp6g04860M-type_MADS family protein
Tp6g04880M-type_MADS family protein
Tp6g06330M-type_MADS family protein
Tp6g07320M-type_MADS family protein
Tp6g13190M-type_MADS family protein
Tp6g13570M-type_MADS family protein
Tp6g17600M-type_MADS family protein
Tp6g20590M-type_MADS family protein
Tp6g22010M-type_MADS family protein
Tp6g22020M-type_MADS family protein
Tp6g36360M-type_MADS family protein
Tp7g23460M-type_MADS family protein
Tp7g34230M-type_MADS family protein
Tp7g35100M-type_MADS family protein
Tp_un0001_062M-type_MADS family protein
Tp_un0302_001M-type_MADS family protein
Tp_un0779_001M-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513