PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Thellungiella parvula
HD-ZIP Family
Species TF ID Description
Tp5g24890HD-ZIP family protein
Tp6g36150HD-ZIP family protein
Tp4g01450HD-ZIP family protein
Tp7g35790HD-ZIP family protein
Tp2g28420HD-ZIP family protein
Tp6g28920HD-ZIP family protein
Tp7g17330HD-ZIP family protein
Tp3g32030HD-ZIP family protein
Tp3g00880HD-ZIP family protein
Tp4g01820HD-ZIP family protein
Tp4g26980HD-ZIP family protein
Tp7g35440HD-ZIP family protein
Tp7g16730HD-ZIP family protein
Tp5g02830HD-ZIP family protein
Tp_un0080_001HD-ZIP family protein
Tp1g21820HD-ZIP family protein
Tp3g00600HD-ZIP family protein
Tp2g12090HD-ZIP family protein
Tp2g30000HD-ZIP family protein
Tp4g28720HD-ZIP family protein
Tp5g01460HD-ZIP family protein
Tp2g12870HD-ZIP family protein
Tp6g38940HD-ZIP family protein
Tp1g21740HD-ZIP family protein
Tp6g38930HD-ZIP family protein
Tp5g26090HD-ZIP family protein
Tp4g18890HD-ZIP family protein
Tp7g01690HD-ZIP family protein
Tp_un0727_001HD-ZIP family protein
Tp5g35920HD-ZIP family protein
Tp1g04080HD-ZIP family protein
Tp_un0024_006HD-ZIP family protein
Tp6g04070HD-ZIP family protein
Tp7g19920HD-ZIP family protein
Tp6g00710HD-ZIP family protein
Tp7g30650HD-ZIP family protein
Tp4g16990HD-ZIP family protein
Tp5g02230HD-ZIP family protein
Tp4g27810HD-ZIP family protein
Tp4g14740HD-ZIP family protein
Tp6g14420HD-ZIP family protein
Tp1g26330HD-ZIP family protein
Tp1g38700HD-ZIP family protein
Tp5g28290HD-ZIP family protein
Tp5g16120HD-ZIP family protein
Tp6g22260HD-ZIP family protein
Tp1g15990HD-ZIP family protein
Tp2g11680HD-ZIP family protein
Tp6g26910HD-ZIP family protein
Tp7g23550HD-ZIP family protein
Tp3g02290HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401