PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Tarenaya hassleriana
MIKC_MADS Family
Species TF ID Description
XP_010518865.1MIKC_MADS family protein
XP_010518970.1MIKC_MADS family protein
XP_010518976.1MIKC_MADS family protein
XP_010519690.1MIKC_MADS family protein
XP_010519700.1MIKC_MADS family protein
XP_010519708.1MIKC_MADS family protein
XP_010519728.1MIKC_MADS family protein
XP_010519741.1MIKC_MADS family protein
XP_010520705.1MIKC_MADS family protein
XP_010520708.1MIKC_MADS family protein
XP_010520749.1MIKC_MADS family protein
XP_010520750.1MIKC_MADS family protein
XP_010520751.1MIKC_MADS family protein
XP_010520827.1MIKC_MADS family protein
XP_010520846.1MIKC_MADS family protein
XP_010521205.1MIKC_MADS family protein
XP_010521206.1MIKC_MADS family protein
XP_010522050.1MIKC_MADS family protein
XP_010522059.1MIKC_MADS family protein
XP_010522067.1MIKC_MADS family protein
XP_010522074.1MIKC_MADS family protein
XP_010522082.1MIKC_MADS family protein
XP_010522467.1MIKC_MADS family protein
XP_010523346.1MIKC_MADS family protein
XP_010523347.1MIKC_MADS family protein
XP_010523348.1MIKC_MADS family protein
XP_010523499.1MIKC_MADS family protein
XP_010523708.1MIKC_MADS family protein
XP_010523709.1MIKC_MADS family protein
XP_010523711.1MIKC_MADS family protein
XP_010523712.1MIKC_MADS family protein
XP_010525329.1MIKC_MADS family protein
XP_010525336.1MIKC_MADS family protein
XP_010525339.1MIKC_MADS family protein
XP_010525343.1MIKC_MADS family protein
XP_010526675.1MIKC_MADS family protein
XP_010527021.1MIKC_MADS family protein
XP_010527508.1MIKC_MADS family protein
XP_010527982.1MIKC_MADS family protein
XP_010528425.1MIKC_MADS family protein
XP_010529519.1MIKC_MADS family protein
XP_010529520.1MIKC_MADS family protein
XP_010529521.1MIKC_MADS family protein
XP_010530248.1MIKC_MADS family protein
XP_010530256.1MIKC_MADS family protein
XP_010530322.1MIKC_MADS family protein
XP_010530323.1MIKC_MADS family protein
XP_010530324.1MIKC_MADS family protein
XP_010530389.1MIKC_MADS family protein
XP_010530561.1MIKC_MADS family protein
XP_010530562.1MIKC_MADS family protein
XP_010531071.1MIKC_MADS family protein
XP_010531079.1MIKC_MADS family protein
XP_010531345.1MIKC_MADS family protein
XP_010532202.1MIKC_MADS family protein
XP_010532203.1MIKC_MADS family protein
XP_010532204.1MIKC_MADS family protein
XP_010532206.1MIKC_MADS family protein
XP_010532441.1MIKC_MADS family protein
XP_010532442.1MIKC_MADS family protein
XP_010534127.1MIKC_MADS family protein
XP_010536502.1MIKC_MADS family protein
XP_010538582.1MIKC_MADS family protein
XP_010538787.1MIKC_MADS family protein
XP_010538788.1MIKC_MADS family protein
XP_010538789.1MIKC_MADS family protein
XP_010541718.1MIKC_MADS family protein
XP_010541719.1MIKC_MADS family protein
XP_010542871.1MIKC_MADS family protein
XP_010542875.1MIKC_MADS family protein
XP_010544676.1MIKC_MADS family protein
XP_010544677.1MIKC_MADS family protein
XP_010544678.1MIKC_MADS family protein
XP_010544679.1MIKC_MADS family protein
XP_010544680.1MIKC_MADS family protein
XP_010545163.1MIKC_MADS family protein
XP_010545211.1MIKC_MADS family protein
XP_010546076.1MIKC_MADS family protein
XP_010546077.1MIKC_MADS family protein
XP_010546078.1MIKC_MADS family protein
XP_010547302.1MIKC_MADS family protein
XP_010547303.1MIKC_MADS family protein
XP_010547305.1MIKC_MADS family protein
XP_010547306.1MIKC_MADS family protein
XP_010547620.1MIKC_MADS family protein
XP_010547743.1MIKC_MADS family protein
XP_010547744.1MIKC_MADS family protein
XP_010549963.1MIKC_MADS family protein
XP_010551359.1MIKC_MADS family protein
XP_010552418.1MIKC_MADS family protein
XP_010552551.1MIKC_MADS family protein
XP_010554818.1MIKC_MADS family protein
XP_010554819.1MIKC_MADS family protein
XP_010555321.1MIKC_MADS family protein
XP_010555411.1MIKC_MADS family protein
XP_010555422.1MIKC_MADS family protein
XP_010555639.1MIKC_MADS family protein
XP_010557822.1MIKC_MADS family protein
XP_010558530.1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513