PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Tarenaya hassleriana
HD-ZIP Family
Species TF ID Description
XP_010550130.1HD-ZIP family protein
XP_010550131.1HD-ZIP family protein
XP_010551895.1HD-ZIP family protein
XP_010523302.1HD-ZIP family protein
XP_010523301.1HD-ZIP family protein
XP_010555396.1HD-ZIP family protein
XP_010524329.1HD-ZIP family protein
XP_010526667.1HD-ZIP family protein
XP_010532854.1HD-ZIP family protein
XP_010529979.1HD-ZIP family protein
XP_010557949.1HD-ZIP family protein
XP_010538408.1HD-ZIP family protein
XP_010550065.1HD-ZIP family protein
XP_010534362.1HD-ZIP family protein
XP_010531658.1HD-ZIP family protein
XP_010543827.1HD-ZIP family protein
XP_010531317.1HD-ZIP family protein
XP_010555437.1HD-ZIP family protein
XP_010519326.1HD-ZIP family protein
XP_010551522.1HD-ZIP family protein
XP_010524427.1HD-ZIP family protein
XP_010552589.1HD-ZIP family protein
XP_010544578.1HD-ZIP family protein
XP_010526695.1HD-ZIP family protein
XP_010559143.1HD-ZIP family protein
XP_010544870.1HD-ZIP family protein
XP_010527776.1HD-ZIP family protein
XP_010527775.1HD-ZIP family protein
XP_010548355.1HD-ZIP family protein
XP_010531178.1HD-ZIP family protein
XP_010554975.1HD-ZIP family protein
XP_010552709.1HD-ZIP family protein
XP_010558140.1HD-ZIP family protein
XP_010526748.1HD-ZIP family protein
XP_010528264.1HD-ZIP family protein
XP_010558215.1HD-ZIP family protein
XP_010554012.1HD-ZIP family protein
XP_010554014.1HD-ZIP family protein
XP_010558970.1HD-ZIP family protein
XP_010521473.1HD-ZIP family protein
XP_010537037.1HD-ZIP family protein
XP_010558832.1HD-ZIP family protein
XP_010520926.1HD-ZIP family protein
XP_010552710.1HD-ZIP family protein
XP_010529425.1HD-ZIP family protein
XP_010521515.1HD-ZIP family protein
XP_010538642.1HD-ZIP family protein
XP_010538651.1HD-ZIP family protein
XP_010522330.1HD-ZIP family protein
XP_010523041.1HD-ZIP family protein
XP_010523042.1HD-ZIP family protein
XP_010544375.1HD-ZIP family protein
XP_010526102.1HD-ZIP family protein
XP_010526103.1HD-ZIP family protein
XP_010537199.1HD-ZIP family protein
XP_010537200.1HD-ZIP family protein
XP_010537201.1HD-ZIP family protein
XP_010537202.1HD-ZIP family protein
XP_010537203.1HD-ZIP family protein
XP_010537204.1HD-ZIP family protein
XP_010537198.1HD-ZIP family protein
XP_010537197.1HD-ZIP family protein
XP_010523728.1HD-ZIP family protein
XP_010555656.1HD-ZIP family protein
XP_010555657.1HD-ZIP family protein
XP_010555658.1HD-ZIP family protein
XP_010555655.1HD-ZIP family protein
XP_010555654.1HD-ZIP family protein
XP_010544689.1HD-ZIP family protein
XP_010519070.1HD-ZIP family protein
XP_010535179.1HD-ZIP family protein
XP_010538268.1HD-ZIP family protein
XP_010545669.1HD-ZIP family protein
XP_010545670.1HD-ZIP family protein
XP_010545671.1HD-ZIP family protein
XP_010545672.1HD-ZIP family protein
XP_010545673.1HD-ZIP family protein
XP_010537520.1HD-ZIP family protein
XP_010535608.1HD-ZIP family protein
XP_010540042.1HD-ZIP family protein
XP_010540044.1HD-ZIP family protein
XP_010540045.1HD-ZIP family protein
XP_010540046.1HD-ZIP family protein
XP_010518669.1HD-ZIP family protein
XP_010518670.1HD-ZIP family protein
XP_010518671.1HD-ZIP family protein
XP_010520372.1HD-ZIP family protein
XP_010550261.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401