PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Theobroma cacao
HD-ZIP Family
Species TF ID Description
Thecc1EG016864t1HD-ZIP family protein
Thecc1EG011764t1HD-ZIP family protein
Thecc1EG015919t1HD-ZIP family protein
Thecc1EG034849t1HD-ZIP family protein
Thecc1EG018470t1HD-ZIP family protein
Thecc1EG001039t3HD-ZIP family protein
Thecc1EG001039t1HD-ZIP family protein
Thecc1EG001039t2HD-ZIP family protein
Thecc1EG013821t1HD-ZIP family protein
Thecc1EG013821t2HD-ZIP family protein
Thecc1EG024940t1HD-ZIP family protein
Thecc1EG009970t2HD-ZIP family protein
Thecc1EG009970t1HD-ZIP family protein
Thecc1EG005689t1HD-ZIP family protein
Thecc1EG000867t1HD-ZIP family protein
Thecc1EG034628t1HD-ZIP family protein
Thecc1EG015486t1HD-ZIP family protein
Thecc1EG005074t1HD-ZIP family protein
Thecc1EG000438t1HD-ZIP family protein
Thecc1EG022391t1HD-ZIP family protein
Thecc1EG010868t1HD-ZIP family protein
Thecc1EG015645t1HD-ZIP family protein
Thecc1EG031644t1HD-ZIP family protein
Thecc1EG013821t3HD-ZIP family protein
Thecc1EG028767t2HD-ZIP family protein
Thecc1EG028767t1HD-ZIP family protein
Thecc1EG011330t2HD-ZIP family protein
Thecc1EG011330t3HD-ZIP family protein
Thecc1EG011330t1HD-ZIP family protein
Thecc1EG030175t1HD-ZIP family protein
Thecc1EG030175t2HD-ZIP family protein
Thecc1EG030175t3HD-ZIP family protein
Thecc1EG005412t3HD-ZIP family protein
Thecc1EG005412t2HD-ZIP family protein
Thecc1EG005412t1HD-ZIP family protein
Thecc1EG037207t2HD-ZIP family protein
Thecc1EG037207t3HD-ZIP family protein
Thecc1EG037207t1HD-ZIP family protein
Thecc1EG028866t1HD-ZIP family protein
Thecc1EG044944t1HD-ZIP family protein
Thecc1EG026907t6HD-ZIP family protein
Thecc1EG026907t4HD-ZIP family protein
Thecc1EG026907t3HD-ZIP family protein
Thecc1EG026907t1HD-ZIP family protein
Thecc1EG026907t5HD-ZIP family protein
Thecc1EG015114t2HD-ZIP family protein
Thecc1EG015114t3HD-ZIP family protein
Thecc1EG015114t1HD-ZIP family protein
Thecc1EG042062t4HD-ZIP family protein
Thecc1EG042062t3HD-ZIP family protein
Thecc1EG042062t1HD-ZIP family protein
Thecc1EG042062t2HD-ZIP family protein
Thecc1EG016582t2HD-ZIP family protein
Thecc1EG016582t1HD-ZIP family protein
Thecc1EG017892t1HD-ZIP family protein
Thecc1EG015114t4HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401