PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Triticum aestivum
MIKC_MADS Family
Species TF ID Description
Traes_1AL_1B5F51626.1MIKC_MADS family protein
Traes_1AL_5F5A87122.2MIKC_MADS family protein
Traes_1AL_6B108514B.1MIKC_MADS family protein
Traes_1AS_985BB33A1.2MIKC_MADS family protein
Traes_1BL_B44C0D37C.1MIKC_MADS family protein
Traes_1DL_6DA0DFC5B.1MIKC_MADS family protein
Traes_1DL_D25CDC57D.1MIKC_MADS family protein
Traes_1DS_F22A3DB6A.1MIKC_MADS family protein
Traes_1DS_F70AAB507.2MIKC_MADS family protein
Traes_2AL_20C2D79E1.2MIKC_MADS family protein
Traes_2AL_8DF89AA72.1MIKC_MADS family protein
Traes_2BL_26F24E716.1MIKC_MADS family protein
Traes_2BL_E0978B1BC.1MIKC_MADS family protein
Traes_2BS_4818EA1FF.1MIKC_MADS family protein
Traes_2DL_6CD5A5CD9.2MIKC_MADS family protein
Traes_2DL_71F120931.1MIKC_MADS family protein
Traes_2DL_903A29CBA.1MIKC_MADS family protein
Traes_3AL_219064574.1MIKC_MADS family protein
Traes_3AS_55E9080C2.2MIKC_MADS family protein
TRAES3BF021600020CFD_t1MIKC_MADS family protein
TRAES3BF048900050CFD_t1MIKC_MADS family protein
TRAES3BF068500020CFD_t1MIKC_MADS family protein
Traes_5AL_01329A110.1MIKC_MADS family protein
Traes_5AS_7BFB385EF.3MIKC_MADS family protein
Traes_5AS_E9E60BA43.2MIKC_MADS family protein
Traes_5BL_4CA71C036.1MIKC_MADS family protein
Traes_5BL_9627436AE.1MIKC_MADS family protein
Traes_5DL_9CC4EC839.1MIKC_MADS family protein
Traes_5DS_16243E52C.2MIKC_MADS family protein
Traes_6AL_1F7DAC5FA.2MIKC_MADS family protein
Traes_6AL_A93C6F2FC.1MIKC_MADS family protein
Traes_6AS_57E50EE92.3MIKC_MADS family protein
Traes_6AS_9AA76345D.1MIKC_MADS family protein
Traes_6AS_D6ABA1D79.1MIKC_MADS family protein
Traes_6BL_7C6B17284.2MIKC_MADS family protein
Traes_6BS_5789476CB.2MIKC_MADS family protein
Traes_6BS_8F1EC63B9.1MIKC_MADS family protein
Traes_6DL_5B1D4DBF5.2MIKC_MADS family protein
Traes_6DL_D1C1DBD34.1MIKC_MADS family protein
Traes_6DL_D8C9E421C.2MIKC_MADS family protein
Traes_6DS_9BBDCC9F7.2MIKC_MADS family protein
Traes_7AL_1C76E543C.1MIKC_MADS family protein
Traes_7AL_67921A952.2MIKC_MADS family protein
Traes_7AS_0CD3B69E7.2MIKC_MADS family protein
Traes_7AS_8123257BA.1MIKC_MADS family protein
Traes_7AS_C25A349A9.1MIKC_MADS family protein
Traes_7BL_9BCF391CF.2MIKC_MADS family protein
Traes_7BS_9D42F9BEA.2MIKC_MADS family protein
Traes_7DL_CAF83263E.2MIKC_MADS family protein
Traes_7DL_DDCC09B24.1MIKC_MADS family protein
Traes_7DS_68DE33D2A.1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513