PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Triticum aestivum
M-type_MADS Family
Species TF ID Description
Traes_1AL_6F5982F88.1M-type_MADS family protein
Traes_1AS_24511D656.1M-type_MADS family protein
Traes_1AS_3232D5589.1M-type_MADS family protein
Traes_1BL_F1D5BF5F8.2M-type_MADS family protein
Traes_1BS_05948C723.1M-type_MADS family protein
Traes_1BS_1202C8C0D.2M-type_MADS family protein
Traes_1BS_7366111C0.1M-type_MADS family protein
Traes_1BS_7366111C01.1M-type_MADS family protein
Traes_1DL_D5BBCA2D0.1M-type_MADS family protein
Traes_1DS_A0312C264.1M-type_MADS family protein
Traes_2AL_0C169500B.1M-type_MADS family protein
Traes_2AL_267502097.2M-type_MADS family protein
Traes_2BL_3E613DE21.2M-type_MADS family protein
Traes_2BL_ABBC40952.1M-type_MADS family protein
Traes_2DL_3C9A3DD05.1M-type_MADS family protein
Traes_2DL_662837152.1M-type_MADS family protein
Traes_2DL_6A10DD109.1M-type_MADS family protein
Traes_3AS_B4247C855.1M-type_MADS family protein
TRAES3BF009000010CFD_t1M-type_MADS family protein
TRAES3BF009000040CFD_t1M-type_MADS family protein
TRAES3BF024100070CFD_t1M-type_MADS family protein
TRAES3BF073700150CFD_t1M-type_MADS family protein
TRAES3BF077200070CFD_t1M-type_MADS family protein
TRAES3BF106100060CFD_t1M-type_MADS family protein
TRAES3BF154600030CFD_t1M-type_MADS family protein
Traes_3DS_51A589227.1M-type_MADS family protein
Traes_4AL_72A03AD23.1M-type_MADS family protein
Traes_4AL_8DBE120BC.2M-type_MADS family protein
Traes_4AS_BE7BCEFEC.1M-type_MADS family protein
Traes_4AS_E1E60C5E5.1M-type_MADS family protein
Traes_4BL_410DEBFD3.2M-type_MADS family protein
Traes_4BL_9A17EA3B7.1M-type_MADS family protein
Traes_4BL_B8FFB0854.2M-type_MADS family protein
Traes_4BS_59C6DEC88.2M-type_MADS family protein
Traes_4BS_8B4AFA7C2.2M-type_MADS family protein
Traes_4DL_008F8BBFA.1M-type_MADS family protein
Traes_4DL_5633C0561.1M-type_MADS family protein
Traes_4DL_67EFB6303.2M-type_MADS family protein
Traes_4DL_964466BEC.1M-type_MADS family protein
Traes_4DL_C4CB3D5AF.1M-type_MADS family protein
Traes_4DS_4C4EB1D21.2M-type_MADS family protein
Traes_4DS_A28BC582A.1M-type_MADS family protein
Traes_5AS_029A65B0A.2M-type_MADS family protein
Traes_5BL_89636D032.1M-type_MADS family protein
Traes_5BS_A19FD8E34.1M-type_MADS family protein
Traes_5BS_BC15EF87A.1M-type_MADS family protein
Traes_5DS_3EBE121C7.1M-type_MADS family protein
Traes_5DS_82FA431DB.1M-type_MADS family protein
Traes_5DS_866BAC69D.1M-type_MADS family protein
Traes_5DS_B288EE729.1M-type_MADS family protein
Traes_6AL_B5D4C3A49.1M-type_MADS family protein
Traes_6DL_609A01BD5.1M-type_MADS family protein
Traes_6DS_2BAD7A60A.1M-type_MADS family protein
Traes_7AS_360247894.1M-type_MADS family protein
Traes_7AS_376CD50EA.1M-type_MADS family protein
Traes_7AS_ADA694FCE.2M-type_MADS family protein
Traes_7AS_EFE436F1D.1M-type_MADS family protein
Traes_7AS_F568FCBF1.1M-type_MADS family protein
Traes_7BL_7F4124E70.1M-type_MADS family protein
Traes_7BL_F5B6736D0.1M-type_MADS family protein
Traes_7BS_209950516.1M-type_MADS family protein
Traes_7BS_4D5DE99CC.1M-type_MADS family protein
Traes_7BS_592EC3AB1.1M-type_MADS family protein
Traes_7BS_DC9822CEF.1M-type_MADS family protein
Traes_7BS_F4CFCDF52.1M-type_MADS family protein
Traes_7DL_15FC3C682.1M-type_MADS family protein
Traes_7DL_303249AE4.1M-type_MADS family protein
Traes_7DL_A773A64E2.2M-type_MADS family protein
Traes_7DS_05F0F0B64.1M-type_MADS family protein
Traes_7DS_366A869CF.3M-type_MADS family protein
Traes_7DS_4AF5C695F.1M-type_MADS family protein
Traes_7DS_4DF7EB08F.1M-type_MADS family protein
Traes_7DS_59CBF5647.2M-type_MADS family protein
Traes_7DS_7A30E1397.1M-type_MADS family protein
Traes_7DS_7F8C88C92.2M-type_MADS family protein
Traes_7DS_D435DF316.1M-type_MADS family protein
Traes_7DS_D9008CC09.1M-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513