PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Solanum tuberosum
Species TF ID Description
PGSC0003DMP400000026MIKC_MADS family protein
PGSC0003DMP400000027MIKC_MADS family protein
PGSC0003DMP400000297MIKC_MADS family protein
PGSC0003DMP400002481MIKC_MADS family protein
PGSC0003DMP400002482MIKC_MADS family protein
PGSC0003DMP400002483MIKC_MADS family protein
PGSC0003DMP400006318MIKC_MADS family protein
PGSC0003DMP400006319MIKC_MADS family protein
PGSC0003DMP400006615MIKC_MADS family protein
PGSC0003DMP400006616MIKC_MADS family protein
PGSC0003DMP400007292MIKC_MADS family protein
PGSC0003DMP400007293MIKC_MADS family protein
PGSC0003DMP400009183MIKC_MADS family protein
PGSC0003DMP400009184MIKC_MADS family protein
PGSC0003DMP400011974MIKC_MADS family protein
PGSC0003DMP400011975MIKC_MADS family protein
PGSC0003DMP400011976MIKC_MADS family protein
PGSC0003DMP400013088MIKC_MADS family protein
PGSC0003DMP400013090MIKC_MADS family protein
PGSC0003DMP400016560MIKC_MADS family protein
PGSC0003DMP400018138MIKC_MADS family protein
PGSC0003DMP400026671MIKC_MADS family protein
PGSC0003DMP400026672MIKC_MADS family protein
PGSC0003DMP400028305MIKC_MADS family protein
PGSC0003DMP400030218MIKC_MADS family protein
PGSC0003DMP400031037MIKC_MADS family protein
PGSC0003DMP400031038MIKC_MADS family protein
PGSC0003DMP400031039MIKC_MADS family protein
PGSC0003DMP400031040MIKC_MADS family protein
PGSC0003DMP400031041MIKC_MADS family protein
PGSC0003DMP400037925MIKC_MADS family protein
PGSC0003DMP400039436MIKC_MADS family protein
PGSC0003DMP400039437MIKC_MADS family protein
PGSC0003DMP400039438MIKC_MADS family protein
PGSC0003DMP400041061MIKC_MADS family protein
PGSC0003DMP400042628MIKC_MADS family protein
PGSC0003DMP400042629MIKC_MADS family protein
PGSC0003DMP400042630MIKC_MADS family protein
PGSC0003DMP400044272MIKC_MADS family protein
PGSC0003DMP400044273MIKC_MADS family protein
PGSC0003DMP400044274MIKC_MADS family protein
PGSC0003DMP400046162MIKC_MADS family protein
PGSC0003DMP400046163MIKC_MADS family protein
PGSC0003DMP400049309MIKC_MADS family protein
PGSC0003DMP400049310MIKC_MADS family protein
PGSC0003DMP400049311MIKC_MADS family protein
PGSC0003DMP400049312MIKC_MADS family protein
PGSC0003DMP400049313MIKC_MADS family protein
PGSC0003DMP400049482MIKC_MADS family protein
PGSC0003DMP400049483MIKC_MADS family protein
PGSC0003DMP400049484MIKC_MADS family protein
PGSC0003DMP400056040MIKC_MADS family protein
PGSC0003DMP400056041MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513