PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Solanum tuberosum
E2F/DP Family
Species TF ID Description
PGSC0003DMP400002324E2F/DP family protein
PGSC0003DMP400002325E2F/DP family protein
PGSC0003DMP400002326E2F/DP family protein
PGSC0003DMP400006748E2F/DP family protein
PGSC0003DMP400006749E2F/DP family protein
PGSC0003DMP400010519E2F/DP family protein
PGSC0003DMP400010520E2F/DP family protein
PGSC0003DMP400014698E2F/DP family protein
PGSC0003DMP400014699E2F/DP family protein
PGSC0003DMP400015689E2F/DP family protein
PGSC0003DMP400015690E2F/DP family protein
PGSC0003DMP400015691E2F/DP family protein
PGSC0003DMP400028726E2F/DP family protein
PGSC0003DMP400028727E2F/DP family protein
PGSC0003DMP400028728E2F/DP family protein
PGSC0003DMP400034101E2F/DP family protein
PGSC0003DMP400034102E2F/DP family protein
PGSC0003DMP400034104E2F/DP family protein
PGSC0003DMP400042303E2F/DP family protein
PGSC0003DMP400042307E2F/DP family protein
E2F/DP Family Introduction

E2F transcription factors are a family of proteins that share a related DNA-binding domain and that bind to overlapping sets of target promoters. Most E2F proteins associate with a DP protein and form heterodimeric complexes that bind to DNA in a sequence-specific manner. E2F proteins control the temporal expression of genes that are needed for multiple processes during the cell cycle. Consequently, the level of E2F-dependent transcription is important for cell proliferation.

Different types of E2F complexes either activate or repress transcription. E2F repressor complexes suppress the transcription of their targets in quiescent cells, in differentiated cells and during the G1 phase of the cell cycle. When cells enter the cell cycle and proliferate, these repressors are disrupted and/or replaced by activator forms of E2F that promote gene expression.

van den Heuvel S, Dyson NJ.
Conserved functions of the pRB and E2F families.
Nat Rev Mol Cell Biol, 2008. 9(9): p. 713-24.
PMID: 18719710