PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Solanum pimpinellifolium
bHLH Family
Species TF ID Description
Sopim00g050430.0.1bHLH family protein
Sopim01g010130.0.1bHLH family protein
Sopim01g014910.0.1bHLH family protein
Sopim01g014960.0.1bHLH family protein
Sopim01g020170.0.1bHLH family protein
Sopim01g057300.0.1bHLH family protein
Sopim01g080050.0.1bHLH family protein
Sopim01g081090.0.1bHLH family protein
Sopim01g081100.0.1bHLH family protein
Sopim01g086870.0.1bHLH family protein
Sopim01g090790.0.1bHLH family protein
Sopim01g096050.0.1bHLH family protein
Sopim01g096370.0.1bHLH family protein
Sopim01g098720.0.1bHLH family protein
Sopim01g102300.0.1bHLH family protein
Sopim01g106460.0.1bHLH family protein
Sopim01g107140.0.1bHLH family protein
Sopim01g107950.0.1bHLH family protein
Sopim01g107960.0.1bHLH family protein
Sopim01g107970.0.1bHLH family protein
Sopim01g109700.0.1bHLH family protein
Sopim01g111130.0.1bHLH family protein
Sopim02g062690.0.1bHLH family protein
Sopim02g063430.0.1bHLH family protein
Sopim02g067380.0.1bHLH family protein
Sopim02g070880.0.1bHLH family protein
Sopim02g076920.0.1bHLH family protein
Sopim02g078130.0.1bHLH family protein
Sopim02g079810.0.1bHLH family protein
Sopim02g079970.0.1bHLH family protein
Sopim02g084880.0.1bHLH family protein
Sopim02g087860.0.1bHLH family protein
Sopim02g090950.0.1bHLH family protein
Sopim02g091440.0.1bHLH family protein
Sopim02g091690.0.1bHLH family protein
Sopim02g091800.0.1bHLH family protein
Sopim02g091810.0.1bHLH family protein
Sopim02g091820.0.1bHLH family protein
Sopim02g093280.0.1bHLH family protein
Sopim03g005350.0.1bHLH family protein
Sopim03g006910.0.1bHLH family protein
Sopim03g007410.0.1bHLH family protein
Sopim03g031450.0.1bHLH family protein
Sopim03g034000.0.1bHLH family protein
Sopim03g044460.0.1bHLH family protein
Sopim03g095980.0.1bHLH family protein
Sopim03g097820.0.1bHLH family protein
Sopim03g113560.0.1bHLH family protein
Sopim03g114230.0.1bHLH family protein
Sopim03g114720.0.1bHLH family protein
Sopim03g115540.0.1bHLH family protein
Sopim03g118310.0.1bHLH family protein
Sopim03g119390.0.1bHLH family protein
Sopim03g120530.0.1bHLH family protein
Sopim03g121240.0.1bHLH family protein
Sopim04g005130.0.1bHLH family protein
Sopim04g005220.0.1bHLH family protein
Sopim04g005280.0.1bHLH family protein
Sopim04g005660.0.1bHLH family protein
Sopim04g006990.0.1bHLH family protein
Sopim04g007300.0.1bHLH family protein
Sopim04g007430.0.1bHLH family protein
Sopim04g014360.0.1bHLH family protein
Sopim04g058090.0.1bHLH family protein
Sopim04g074810.0.1bHLH family protein
Sopim04g076240.0.1bHLH family protein
Sopim04g077480.0.1bHLH family protein
Sopim04g077960.0.1bHLH family protein
Sopim04g078690.0.1bHLH family protein
Sopim04g078790.0.1bHLH family protein
Sopim04g080710.0.1bHLH family protein
Sopim05g005300.0.1bHLH family protein
Sopim05g006650.0.1bHLH family protein
Sopim05g007210.0.1bHLH family protein
Sopim05g009220.0.1bHLH family protein
Sopim05g009640.0.1bHLH family protein
Sopim05g009880.0.1bHLH family protein
Sopim05g010610.0.1bHLH family protein
Sopim05g011810.0.1bHLH family protein
Sopim05g014590.0.1bHLH family protein
Sopim05g050560.0.1bHLH family protein
Sopim05g053660.0.1bHLH family protein
Sopim06g008030.0.1bHLH family protein
Sopim06g035490.0.1bHLH family protein
Sopim06g050840.0.1bHLH family protein
Sopim06g051260.0.1bHLH family protein
Sopim06g051550.0.1bHLH family protein
Sopim06g062460.0.1bHLH family protein
Sopim06g064580.0.1bHLH family protein
Sopim06g064590.0.1bHLH family protein
Sopim06g065040.0.1bHLH family protein
Sopim06g068870.0.1bHLH family protein
Sopim06g069370.0.1bHLH family protein
Sopim06g069600.0.1bHLH family protein
Sopim06g070910.0.1bHLH family protein
Sopim06g072520.0.1bHLH family protein
Sopim06g083170.0.1bHLH family protein
Sopim06g083980.0.1bHLH family protein
Sopim07g005400.0.1bHLH family protein
Sopim07g018010.0.1bHLH family protein
Sopim07g039570.0.1bHLH family protein
Sopim07g043580.0.1bHLH family protein
Sopim07g052670.0.1bHLH family protein
Sopim07g052930.0.1bHLH family protein
Sopim07g053290.0.1bHLH family protein
Sopim07g062200.0.1bHLH family protein
Sopim07g063830.0.1bHLH family protein
Sopim07g064040.0.1bHLH family protein
Sopim08g005050.0.1bHLH family protein
Sopim08g008600.0.1bHLH family protein
Sopim08g062780.0.1bHLH family protein
Sopim08g075090.0.1bHLH family protein
Sopim08g075110.0.1bHLH family protein
Sopim08g076820.0.1bHLH family protein
Sopim08g076930.0.1bHLH family protein
Sopim08g081140.0.1bHLH family protein
Sopim08g083170.0.1bHLH family protein
Sopim09g005070.0.1bHLH family protein
Sopim09g018130.0.1bHLH family protein
Sopim09g018150.0.1bHLH family protein
Sopim09g057710.0.1bHLH family protein
Sopim09g063010.0.1bHLH family protein
Sopim09g064920.0.1bHLH family protein
Sopim09g065100.0.1bHLH family protein
Sopim09g065820.0.1bHLH family protein
Sopim09g074810.0.1bHLH family protein
Sopim09g083220.0.1bHLH family protein
Sopim09g083360.0.1bHLH family protein
Sopim09g089870.0.1bHLH family protein
Sopim09g091760.0.1bHLH family protein
Sopim09g097870.0.1bHLH family protein
Sopim09g098110.0.1bHLH family protein
Sopim10g006510.0.1bHLH family protein
Sopim10g006640.0.1bHLH family protein
Sopim10g008250.0.1bHLH family protein
Sopim10g008260.0.1bHLH family protein
Sopim10g008270.0.1bHLH family protein
Sopim10g009270.0.1bHLH family protein
Sopim10g009290.0.1bHLH family protein
Sopim10g018510.0.1bHLH family protein
Sopim10g049780.0.1bHLH family protein
Sopim10g078380.0.1bHLH family protein
Sopim10g079050.0.1bHLH family protein
Sopim10g079070.0.1bHLH family protein
Sopim10g079650.0.1bHLH family protein
Sopim10g079660.0.1bHLH family protein
Sopim10g079680.0.1bHLH family protein
Sopim11g005780.0.1bHLH family protein
Sopim11g010340.0.1bHLH family protein
Sopim12g010170.0.1bHLH family protein
Sopim12g036430.0.1bHLH family protein
Sopim12g036470.0.1bHLH family protein
Sopim12g042010.0.1bHLH family protein
Sopim12g087850.0.1bHLH family protein
Sopim12g088130.0.1bHLH family protein
Sopim12g088790.0.1bHLH family protein
Sopim12g098620.0.1bHLH family protein
Sopim12g100140.0.1bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250