PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Solanum pennellii
HD-ZIP Family
Species TF ID Description
Sopen02g031700.1HD-ZIP family protein
Sopen05g003140.1HD-ZIP family protein
Sopen02g032560.1HD-ZIP family protein
Sopen11g005060.1HD-ZIP family protein
Sopen02g016550.1HD-ZIP family protein
Sopen08g026800.1HD-ZIP family protein
Sopen03g032330.1HD-ZIP family protein
Sopen10g031080.1HD-ZIP family protein
Sopen01g036250.1HD-ZIP family protein
Sopen08g003230.1HD-ZIP family protein
Sopen05g029870.1HD-ZIP family protein
Sopen01g033480.1HD-ZIP family protein
Sopen06g020980.1HD-ZIP family protein
Sopen05g002940.1HD-ZIP family protein
Sopen04g029670.1HD-ZIP family protein
Sopen02g036500.1HD-ZIP family protein
Sopen01g040080.1HD-ZIP family protein
Sopen06g018290.1HD-ZIP family protein
Sopen04g001860.1HD-ZIP family protein
Sopen09g003600.1HD-ZIP family protein
Sopen01g006250.1HD-ZIP family protein
Sopen02g030300.1HD-ZIP family protein
Sopen02g014010.1HD-ZIP family protein
Sopen04g030810.1HD-ZIP family protein
Sopen03g022310.1HD-ZIP family protein
Sopen02g014610.1HD-ZIP family protein
Sopen07g028320.1HD-ZIP family protein
Sopen05g003890.1HD-ZIP family protein
Sopen03g006890.1HD-ZIP family protein
Sopen03g006910.1HD-ZIP family protein
Sopen03g006900.1HD-ZIP family protein
Sopen02g022490.1HD-ZIP family protein
Sopen03g006930.1HD-ZIP family protein
Sopen07g031010.1HD-ZIP family protein
Sopen08g031350.1HD-ZIP family protein
Sopen10g002990.1HD-ZIP family protein
Sopen02g024970.1HD-ZIP family protein
Sopen03g005620.1HD-ZIP family protein
Sopen10g001320.1HD-ZIP family protein
Sopen01g037400.1HD-ZIP family protein
Sopen03g028900.1HD-ZIP family protein
Sopen12g001780.1HD-ZIP family protein
Sopen08g020320.1HD-ZIP family protein
Sopen12g022680.1HD-ZIP family protein
Sopen03g039740.1HD-ZIP family protein
Sopen06g028680.1HD-ZIP family protein
Sopen02g006800.1HD-ZIP family protein
Sopen02g018990.1HD-ZIP family protein
Sopen02g018990.2HD-ZIP family protein
Sopen06g011720.1HD-ZIP family protein
Sopen11g028190.1HD-ZIP family protein
Sopen08g024950.2HD-ZIP family protein
Sopen08g024950.1HD-ZIP family protein
Sopen03g004900.1HD-ZIP family protein
Sopen06g015560.1HD-ZIP family protein
Sopen07g021330.1HD-ZIP family protein
Sopen09g027820.3HD-ZIP family protein
Sopen11g006760.1HD-ZIP family protein
Sopen09g021360.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401