PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Selaginella moellendorffii
ERF Family
Species TF ID Description
104978ERF family protein
104980ERF family protein
131245ERF family protein
17648ERF family protein
17708ERF family protein
19889ERF family protein
19890ERF family protein
26594ERF family protein
27203ERF family protein
38494ERF family protein
38500ERF family protein
38502ERF family protein
402810ERF family protein
403257ERF family protein
404338ERF family protein
409196ERF family protein
412693ERF family protein
415574ERF family protein
428344ERF family protein
440731ERF family protein
443366ERF family protein
443461ERF family protein
49950ERF family protein
49951ERF family protein
68470ERF family protein
69413ERF family protein
71661ERF family protein
72871ERF family protein
72880ERF family protein
73134ERF family protein
73136ERF family protein
73138ERF family protein
73140ERF family protein
73146ERF family protein
73148ERF family protein
73155ERF family protein
73157ERF family protein
73160ERF family protein
73164ERF family protein
73165ERF family protein
73177ERF family protein
73232ERF family protein
73854ERF family protein
80895ERF family protein
92334ERF family protein
ERF Family Introduction

The AP2/ERF superfamily is defined by the AP2/ERF domain, which consists of about 60 to 70 amino acids and is involved in DNA binding. These three families have been defined as follows. The AP2 family proteins contain two repeated AP2/ERF domains, the ERF family proteins contain a single AP2/ERF domain, and the RAV family proteins contain a B3 domain, which is a DNA-binding domain conserved in other plant-specific transcription factors, in addition to the single AP2/ERF domain.

It has been demonstrated that the AP2/ERF proteins have important functions in the transcriptional regulation of a variety of biological processes related to growth and development, as well as various responses to environmental stimuli.

After finding the tobacco ERFs, many proteins in the ERF family were identified and implicated in many diverse functions in cellular processes, such as hormonal signal transduction, response to biotic and abiotic stresses, regulation of metabolism, and in developmental processes in various plant species.

Toshitsugu Nakano, Kaoru Suzuki, Tatsuhito Fujimura, and Hideaki Shinshi.
Genome-wide analysis of the ERF gene family in Arabidopsis and rice.
Plant Physiol, 2006. 140(2): p. 411-32.
PMID: 16407444


The first class are proteins which bind to ethylene response elements (ERE) or GCC boxes (tobacco EREBPs, Arabidopsis AtEBP and AtERF1-5, and tomato Pti4-6) found in the promoters of ethylene-inducible pathogenesis related genes. The GCC box is an 11 bp sequence (TAAGAGCCGCC) with a core GCCGCC sequence that is required for binding.
The second class includes proteins that bind to the C-repeat or dehydration response element (DRE) in the promoters of genes that are turned on in response to low temperatures and/or water deficit (CBF1, CBF2, CBF3/DREB1A and DREB2A). The C-repeat/DREs contain the core sequence CCGAC.

Nole-Wilson S, Krizek BA.
DNA binding properties of the Arabidopsis floral development protein AINTEGUMENTA.
Nucleic Acids Res. 2000 Nov 1;28(21):4076-82. Erratum in: Nucleic Acids Res 2001 Mar 1;29(5):1261.
PMID: 11058102