PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Salvia miltiorrhiza
bHLH Family
Species TF ID Description
SMil_00000281-RA_SalvbHLH family protein
SMil_00000353-RA_SalvbHLH family protein
SMil_00000992-RA_SalvbHLH family protein
SMil_00001046-RA_SalvbHLH family protein
SMil_00001130-RA_SalvbHLH family protein
SMil_00001361-RA_SalvbHLH family protein
SMil_00001369-RA_SalvbHLH family protein
SMil_00001370-RA_SalvbHLH family protein
SMil_00001859-RA_SalvbHLH family protein
SMil_00001895-RA_SalvbHLH family protein
SMil_00001968-RA_SalvbHLH family protein
SMil_00002006-RA_SalvbHLH family protein
SMil_00002083-RA_SalvbHLH family protein
SMil_00002569-RA_SalvbHLH family protein
SMil_00002880-RA_SalvbHLH family protein
SMil_00003065-RA_SalvbHLH family protein
SMil_00003180-RA_SalvbHLH family protein
SMil_00003632-RA_SalvbHLH family protein
SMil_00003984-RA_SalvbHLH family protein
SMil_00003992-RA_SalvbHLH family protein
SMil_00004014-RA_SalvbHLH family protein
SMil_00004225-RA_SalvbHLH family protein
SMil_00004393-RA_SalvbHLH family protein
SMil_00004676-RA_SalvbHLH family protein
SMil_00004784-RA_SalvbHLH family protein
SMil_00004838-RA_SalvbHLH family protein
SMil_00004865-RA_SalvbHLH family protein
SMil_00005097-RA_SalvbHLH family protein
SMil_00005108-RA_SalvbHLH family protein
SMil_00005464-RA_SalvbHLH family protein
SMil_00005759-RA_SalvbHLH family protein
SMil_00005944-RA_SalvbHLH family protein
SMil_00006423-RA_SalvbHLH family protein
SMil_00006622-RA_SalvbHLH family protein
SMil_00006890-RA_SalvbHLH family protein
SMil_00006971-RA_SalvbHLH family protein
SMil_00007166-RA_SalvbHLH family protein
SMil_00007184-RA_SalvbHLH family protein
SMil_00007185-RA_SalvbHLH family protein
SMil_00007657-RA_SalvbHLH family protein
SMil_00007696-RA_SalvbHLH family protein
SMil_00007835-RA_SalvbHLH family protein
SMil_00007980-RA_SalvbHLH family protein
SMil_00008194-RA_SalvbHLH family protein
SMil_00008195-RA_SalvbHLH family protein
SMil_00008688-RA_SalvbHLH family protein
SMil_00008717-RA_SalvbHLH family protein
SMil_00008805-RA_SalvbHLH family protein
SMil_00009010-RA_SalvbHLH family protein
SMil_00009275-RA_SalvbHLH family protein
SMil_00009467-RA_SalvbHLH family protein
SMil_00009691-RA_SalvbHLH family protein
SMil_00009727-RA_SalvbHLH family protein
SMil_00009736-RA_SalvbHLH family protein
SMil_00010170-RA_SalvbHLH family protein
SMil_00010274-RA_SalvbHLH family protein
SMil_00010404-RA_SalvbHLH family protein
SMil_00010417-RA_SalvbHLH family protein
SMil_00010559-RA_SalvbHLH family protein
SMil_00010571-RA_SalvbHLH family protein
SMil_00010946-RA_SalvbHLH family protein
SMil_00011129-RA_SalvbHLH family protein
SMil_00011197-RA_SalvbHLH family protein
SMil_00011237-RA_SalvbHLH family protein
SMil_00011353-RA_SalvbHLH family protein
SMil_00011401-RA_SalvbHLH family protein
SMil_00011498-RA_SalvbHLH family protein
SMil_00011523-RA_SalvbHLH family protein
SMil_00011524-RA_SalvbHLH family protein
SMil_00011578-RA_SalvbHLH family protein
SMil_00011704-RA_SalvbHLH family protein
SMil_00011912-RA_SalvbHLH family protein
SMil_00012074-RA_SalvbHLH family protein
SMil_00012109-RA_SalvbHLH family protein
SMil_00012209-RA_SalvbHLH family protein
SMil_00012559-RA_SalvbHLH family protein
SMil_00012735-RA_SalvbHLH family protein
SMil_00013304-RA_SalvbHLH family protein
SMil_00013772-RA_SalvbHLH family protein
SMil_00013893-RA_SalvbHLH family protein
SMil_00013925-RA_SalvbHLH family protein
SMil_00014399-RA_SalvbHLH family protein
SMil_00014486-RA_SalvbHLH family protein
SMil_00014715-RA_SalvbHLH family protein
SMil_00015009-RA_SalvbHLH family protein
SMil_00015081-RA_SalvbHLH family protein
SMil_00015521-RA_SalvbHLH family protein
SMil_00015939-RA_SalvbHLH family protein
SMil_00016107-RA_SalvbHLH family protein
SMil_00016546-RA_SalvbHLH family protein
SMil_00016703-RA_SalvbHLH family protein
SMil_00016848-RA_SalvbHLH family protein
SMil_00017490-RA_SalvbHLH family protein
SMil_00017508-RA_SalvbHLH family protein
SMil_00017552-RA_SalvbHLH family protein
SMil_00017818-RA_SalvbHLH family protein
SMil_00017887-RA_SalvbHLH family protein
SMil_00018128-RA_SalvbHLH family protein
SMil_00018390-RA_SalvbHLH family protein
SMil_00018836-RA_SalvbHLH family protein
SMil_00019228-RA_SalvbHLH family protein
SMil_00019286-RA_SalvbHLH family protein
SMil_00019414-RA_SalvbHLH family protein
SMil_00019538-RA_SalvbHLH family protein
SMil_00019739-RA_SalvbHLH family protein
SMil_00019907-RA_SalvbHLH family protein
SMil_00020000-RA_SalvbHLH family protein
SMil_00020876-RA_SalvbHLH family protein
SMil_00020944-RA_SalvbHLH family protein
SMil_00021379-RA_SalvbHLH family protein
SMil_00021481-RA_SalvbHLH family protein
SMil_00021973-RA_SalvbHLH family protein
SMil_00022202-RA_SalvbHLH family protein
SMil_00022320-RA_SalvbHLH family protein
SMil_00022386-RA_SalvbHLH family protein
SMil_00022426-RA_SalvbHLH family protein
SMil_00022447-RA_SalvbHLH family protein
SMil_00022596-RA_SalvbHLH family protein
SMil_00022608-RA_SalvbHLH family protein
SMil_00022792-RA_SalvbHLH family protein
SMil_00023118-RA_SalvbHLH family protein
SMil_00023296-RA_SalvbHLH family protein
SMil_00023539-RA_SalvbHLH family protein
SMil_00023563-RA_SalvbHLH family protein
SMil_00023988-RA_SalvbHLH family protein
SMil_00024023-RA_SalvbHLH family protein
SMil_00024126-RA_SalvbHLH family protein
SMil_00024330-RA_SalvbHLH family protein
SMil_00024366-RA_SalvbHLH family protein
SMil_00024679-RA_SalvbHLH family protein
SMil_00025539-RA_SalvbHLH family protein
SMil_00025565-RA_SalvbHLH family protein
SMil_00025712-RA_SalvbHLH family protein
SMil_00025808-RA_SalvbHLH family protein
SMil_00026150-RA_SalvbHLH family protein
SMil_00026151-RA_SalvbHLH family protein
SMil_00026336-RA_SalvbHLH family protein
SMil_00026337-RA_SalvbHLH family protein
SMil_00026727-RA_SalvbHLH family protein
SMil_00026829-RA_SalvbHLH family protein
SMil_00027079-RA_SalvbHLH family protein
SMil_00027212-RA_SalvbHLH family protein
SMil_00027340-RA_SalvbHLH family protein
SMil_00027754-RA_SalvbHLH family protein
SMil_00027756-RA_SalvbHLH family protein
SMil_00028041-RA_SalvbHLH family protein
SMil_00028115-RA_SalvbHLH family protein
SMil_00029368-RA_SalvbHLH family protein
SMil_00029392-RA_SalvbHLH family protein
SMil_00029733-RA_SalvbHLH family protein
SMil_00029866-RA_SalvbHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250