PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Solanum lycopersicum
HD-ZIP Family
Species TF ID Description
Solyc02g086930.2.1HD-ZIP family protein
Solyc05g007180.2.1HD-ZIP family protein
Solyc02g087840.2.1HD-ZIP family protein
Solyc11g010270.1.1HD-ZIP family protein
Solyc08g078300.2.1HD-ZIP family protein
Solyc02g067410.1.1HD-ZIP family protein
Solyc03g113270.2.1HD-ZIP family protein
Solyc10g080540.1.1HD-ZIP family protein
Solyc05g051460.2.1HD-ZIP family protein
Solyc08g007270.2.1HD-ZIP family protein
Solyc01g073910.2.1HD-ZIP family protein
Solyc06g060830.2.1HD-ZIP family protein
Solyc01g090460.2.1HD-ZIP family protein
Solyc01g096320.2.1HD-ZIP family protein
Solyc05g006980.2.1HD-ZIP family protein
Solyc04g074700.2.1HD-ZIP family protein
Solyc02g091930.2.1HD-ZIP family protein
Solyc06g053220.2.1HD-ZIP family protein
Solyc04g005800.2.1HD-ZIP family protein
Solyc02g085630.2.1HD-ZIP family protein
Solyc09g008810.2.1HD-ZIP family protein
Solyc02g062960.2.1HD-ZIP family protein
Solyc04g077220.2.1HD-ZIP family protein
Solyc01g010600.2.1HD-ZIP family protein
Solyc03g082550.2.1HD-ZIP family protein
Solyc07g054380.1.1HD-ZIP family protein
Solyc05g008050.1.1HD-ZIP family protein
Solyc02g063520.2.1HD-ZIP family protein
Solyc03g034110.2.1HD-ZIP family protein
Solyc02g077590.1.1HD-ZIP family protein
Solyc03g034120.2.1HD-ZIP family protein
Solyc03g034130.2.1HD-ZIP family protein
Solyc03g034150.1.1HD-ZIP family protein
Solyc08g083130.2.1HD-ZIP family protein
Solyc07g062790.1.1HD-ZIP family protein
Solyc02g080260.2.1HD-ZIP family protein
Solyc03g120620.2.1HD-ZIP family protein
Solyc10g005330.2.1HD-ZIP family protein
Solyc01g091630.2.1HD-ZIP family protein
Solyc12g005830.1.1HD-ZIP family protein
Solyc03g098200.2.1HD-ZIP family protein
Solyc08g066500.2.1HD-ZIP family protein
Solyc12g044410.1.1HD-ZIP family protein
Solyc03g120910.2.1HD-ZIP family protein
Solyc06g072310.2.1HD-ZIP family protein
Solyc02g069830.2.1HD-ZIP family protein
Solyc02g024070.2.1HD-ZIP family protein
Solyc06g035940.2.1HD-ZIP family protein
Solyc11g069470.1.1HD-ZIP family protein
Solyc08g076370.2.1HD-ZIP family protein
Solyc03g026070.2.1HD-ZIP family protein
Solyc06g050160.2.1HD-ZIP family protein
Solyc07g041850.1.1HD-ZIP family protein
Solyc08g062510.2.1HD-ZIP family protein
Solyc09g066030.1.1HD-ZIP family protein
Solyc11g011940.1.1HD-ZIP family protein
Solyc10g018000.1.1HD-ZIP family protein
Solyc05g015030.1.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401