Plant Transcription Factor Database
v4.0Previous version: v1.0, v2.0, v3.0
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|Solyc01g094580.2.1||BES1 family protein|
|Solyc02g063010.2.1||BES1 family protein|
|Solyc02g071990.2.1||BES1 family protein|
|Solyc03g005990.2.1||BES1 family protein|
|Solyc04g079980.2.1||BES1 family protein|
|Solyc07g062260.2.1||BES1 family protein|
|Solyc08g005780.2.1||BES1 family protein|
|Solyc10g076390.1.1||BES1 family protein|
|Solyc12g089040.1.1||BES1 family protein|
Brassinosteroids (BRs) signal through a plasma membrane-localized receptor kinase to regulate plant growth and development. We showed previously that a novel protein, BES1(BRI1-EMS-SUPPRESSOR 1), accumulates in the nucleus in response to BRs, where it plays a role in BR-regulated gene expression; however, the mechanism by which BES1 regulates gene expression is unknown. In this study, we dissect BES1 subdomains and establish that BES1 is a transcription factor that binds to and activates BR target gene promoters both in vitro and in vivo. BES1 interacts with a basic helix-loop-helix protein, BIM1, to synergistically bind to E box (CANNTG) sequences present in many BR-induced promoters. Loss-of-function and gain-of-function mutants of BIM1 and its close family members display BR response phenotypes. Thus, BES1 defines a new class of plant-specific transcription factors that cooperate with transcription factors such as BIM1 to regulate BR-induced genes.
Yin Y, Vafeados D, Tao Y, Yoshida S, Asami T, Chory J.
A new class of transcription factors mediates brassinosteroid-regulated gene expression in Arabidopsis.
Cell. 2005 Jan 28;120(2):249-59.