PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Sisymbrium irio
WRKY Family
Species TF ID Description
676707074WRKY family protein
676710984WRKY family protein
676711936WRKY family protein
676714300WRKY family protein
676714356WRKY family protein
676717690WRKY family protein
676719194WRKY family protein
676721566WRKY family protein
676721608WRKY family protein
676724330WRKY family protein
676725334WRKY family protein
676725930WRKY family protein
676726210WRKY family protein
676727556WRKY family protein
676727820WRKY family protein
676728392WRKY family protein
676729154WRKY family protein
676729212WRKY family protein
676730990WRKY family protein
676731426WRKY family protein
676732964WRKY family protein
676733684WRKY family protein
676734696WRKY family protein
676734870WRKY family protein
676734888WRKY family protein
676735416WRKY family protein
676735696WRKY family protein
676735698WRKY family protein
676740518WRKY family protein
676740574WRKY family protein
676741292WRKY family protein
676742766WRKY family protein
676743110WRKY family protein
676743368WRKY family protein
676743666WRKY family protein
676744086WRKY family protein
676744138WRKY family protein
676744854WRKY family protein
676745960WRKY family protein
676746008WRKY family protein
676746118WRKY family protein
676746744WRKY family protein
676747156WRKY family protein
676749138WRKY family protein
676749282WRKY family protein
676750094WRKY family protein
676750298WRKY family protein
676752238WRKY family protein
676755090WRKY family protein
676756144WRKY family protein
676758502WRKY family protein
676759030WRKY family protein
676759968WRKY family protein
676762314WRKY family protein
676762930WRKY family protein
676764350WRKY family protein
676767316WRKY family protein
676771814WRKY family protein
676776052WRKY family protein
676779768WRKY family protein
676780060WRKY family protein
676780222WRKY family protein
676781942WRKY family protein
676781994WRKY family protein
676783420WRKY family protein
676786254WRKY family protein
676789432WRKY family protein
WRKY Family Introduction

WRKY transcription factors are one of the largest families of transcriptional regulators in plants and form integral parts of signalling webs that modulate many plant processes. Here, we review recent significant progress in WRKY transcription factor research. New findings illustrate that WRKY proteins often act as repressors as well as activators, and that members of the family play roles in both the repression and de-repression of important plant processes. Furthermore, it is becoming clear that a single WRKY transcription factor might be involved in regulating several seemingly disparate processes. Mechanisms of signalling and transcriptional regulation are being dissected, uncovering WRKY protein functions via interactions with a diverse array of protein partners, including MAP kinases, MAP kinase kinases, 14-3-3 proteins, calmodulin, histone deacetylases, resistance proteins and other WRKY transcription factors. WRKY genes exhibit extensive autoregulation and cross-regulation that facilitates transcriptional reprogramming in a dynamic web with built-in redundancy.

The defining feature of WRKY transcription factors is their DNA binding domain. This is called the WRKY domain after the almost invariant WRKY amino acid sequence at the N-terminus. In a few WRKY proteins, the WRKY amino acid sequences have been replaced by WRRY, WSKY, WKRY, WVKY or WKKY. The WRKY domain is about 60 residues in length, and as well as containing the WRKY signature it also has an atypical zinc-finger structure at the C-terminus. The zinc-finger structure is either Cx4-5Cx22-23HxH or Cx7Cx23HxC. Initially, in the absence of a complete gene family from any plant species, the WRKY transcription factors were divided into three groups based on the number of WRKY domains (two domains in Group I proteins and one in the others) and the structure of their zinc fingers (C2HC in Group III proteins).

Rushton PJ, Somssich IE, Ringler P, Shen QJ.
WRKY transcription factors.
Trends Plant Sci, 2010. 15(5): p. 247-58.
PMID: 20304701