PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Sesamum indicum
bHLH Family
Species TF ID Description
XP_011069808.1bHLH family protein
XP_011070144.1bHLH family protein
XP_011070274.1bHLH family protein
XP_011070769.1bHLH family protein
XP_011070770.1bHLH family protein
XP_011070771.1bHLH family protein
XP_011070838.1bHLH family protein
XP_011070839.1bHLH family protein
XP_011070886.1bHLH family protein
XP_011070888.1bHLH family protein
XP_011070889.1bHLH family protein
XP_011070895.1bHLH family protein
XP_011071014.1bHLH family protein
XP_011071046.1bHLH family protein
XP_011071625.1bHLH family protein
XP_011071748.1bHLH family protein
XP_011071749.1bHLH family protein
XP_011072116.1bHLH family protein
XP_011072388.1bHLH family protein
XP_011072389.1bHLH family protein
XP_011072458.1bHLH family protein
XP_011072763.1bHLH family protein
XP_011072770.1bHLH family protein
XP_011073133.1bHLH family protein
XP_011073134.1bHLH family protein
XP_011073188.1bHLH family protein
XP_011073517.1bHLH family protein
XP_011073652.1bHLH family protein
XP_011073848.1bHLH family protein
XP_011073967.1bHLH family protein
XP_011074290.1bHLH family protein
XP_011074329.1bHLH family protein
XP_011074330.1bHLH family protein
XP_011074391.1bHLH family protein
XP_011074418.1bHLH family protein
XP_011074570.1bHLH family protein
XP_011074571.1bHLH family protein
XP_011074572.1bHLH family protein
XP_011074573.1bHLH family protein
XP_011074574.1bHLH family protein
XP_011074590.1bHLH family protein
XP_011075032.1bHLH family protein
XP_011075183.1bHLH family protein
XP_011075186.1bHLH family protein
XP_011075449.1bHLH family protein
XP_011075476.1bHLH family protein
XP_011075620.1bHLH family protein
XP_011076030.1bHLH family protein
XP_011076269.1bHLH family protein
XP_011076270.1bHLH family protein
XP_011076271.1bHLH family protein
XP_011076299.1bHLH family protein
XP_011076307.1bHLH family protein
XP_011076315.1bHLH family protein
XP_011076501.1bHLH family protein
XP_011076502.1bHLH family protein
XP_011076503.1bHLH family protein
XP_011076504.1bHLH family protein
XP_011076653.1bHLH family protein
XP_011076673.1bHLH family protein
XP_011077316.1bHLH family protein
XP_011077654.1bHLH family protein
XP_011077884.1bHLH family protein
XP_011077906.1bHLH family protein
XP_011078203.1bHLH family protein
XP_011078299.1bHLH family protein
XP_011078318.1bHLH family protein
XP_011078455.1bHLH family protein
XP_011078667.1bHLH family protein
XP_011078682.1bHLH family protein
XP_011078688.1bHLH family protein
XP_011078862.1bHLH family protein
XP_011078863.1bHLH family protein
XP_011078995.1bHLH family protein
XP_011079187.1bHLH family protein
XP_011079825.1bHLH family protein
XP_011079826.1bHLH family protein
XP_011079827.1bHLH family protein
XP_011079838.1bHLH family protein
XP_011079946.1bHLH family protein
XP_011080018.1bHLH family protein
XP_011080019.1bHLH family protein
XP_011080320.1bHLH family protein
XP_011080441.1bHLH family protein
XP_011080466.1bHLH family protein
XP_011080686.1bHLH family protein
XP_011080798.1bHLH family protein
XP_011080799.1bHLH family protein
XP_011080803.1bHLH family protein
XP_011080947.1bHLH family protein
XP_011081344.1bHLH family protein
XP_011081622.1bHLH family protein
XP_011082359.1bHLH family protein
XP_011082365.1bHLH family protein
XP_011082599.1bHLH family protein
XP_011083013.1bHLH family protein
XP_011083064.1bHLH family protein
XP_011083103.1bHLH family protein
XP_011083355.1bHLH family protein
XP_011083625.1bHLH family protein
XP_011083876.1bHLH family protein
XP_011084002.1bHLH family protein
XP_011084160.1bHLH family protein
XP_011084194.1bHLH family protein
XP_011084486.1bHLH family protein
XP_011085262.1bHLH family protein
XP_011085263.1bHLH family protein
XP_011085264.1bHLH family protein
XP_011085297.1bHLH family protein
XP_011085374.1bHLH family protein
XP_011085579.1bHLH family protein
XP_011085580.1bHLH family protein
XP_011085582.1bHLH family protein
XP_011085608.1bHLH family protein
XP_011085763.1bHLH family protein
XP_011085914.1bHLH family protein
XP_011086002.1bHLH family protein
XP_011086065.1bHLH family protein
XP_011086152.1bHLH family protein
XP_011087146.1bHLH family protein
XP_011087147.1bHLH family protein
XP_011087187.1bHLH family protein
XP_011087224.1bHLH family protein
XP_011087225.1bHLH family protein
XP_011087339.1bHLH family protein
XP_011087345.1bHLH family protein
XP_011087566.1bHLH family protein
XP_011087567.1bHLH family protein
XP_011087568.1bHLH family protein
XP_011087740.1bHLH family protein
XP_011088147.1bHLH family protein
XP_011088156.1bHLH family protein
XP_011088239.1bHLH family protein
XP_011088240.1bHLH family protein
XP_011088410.1bHLH family protein
XP_011089037.1bHLH family protein
XP_011089038.1bHLH family protein
XP_011089193.1bHLH family protein
XP_011090104.1bHLH family protein
XP_011090153.1bHLH family protein
XP_011090494.1bHLH family protein
XP_011090795.1bHLH family protein
XP_011090844.1bHLH family protein
XP_011091132.1bHLH family protein
XP_011091133.1bHLH family protein
XP_011091209.1bHLH family protein
XP_011091210.1bHLH family protein
XP_011091423.1bHLH family protein
XP_011091424.1bHLH family protein
XP_011091560.1bHLH family protein
XP_011091561.1bHLH family protein
XP_011091562.1bHLH family protein
XP_011092499.1bHLH family protein
XP_011092500.1bHLH family protein
XP_011092502.1bHLH family protein
XP_011092503.1bHLH family protein
XP_011092504.1bHLH family protein
XP_011092560.1bHLH family protein
XP_011092862.1bHLH family protein
XP_011093025.1bHLH family protein
XP_011093026.1bHLH family protein
XP_011093027.1bHLH family protein
XP_011093295.1bHLH family protein
XP_011093423.1bHLH family protein
XP_011093424.1bHLH family protein
XP_011093536.1bHLH family protein
XP_011093944.1bHLH family protein
XP_011094007.1bHLH family protein
XP_011094110.1bHLH family protein
XP_011094111.1bHLH family protein
XP_011094112.1bHLH family protein
XP_011094113.1bHLH family protein
XP_011094312.1bHLH family protein
XP_011094525.1bHLH family protein
XP_011095314.1bHLH family protein
XP_011095780.1bHLH family protein
XP_011096123.1bHLH family protein
XP_011096168.1bHLH family protein
XP_011096171.1bHLH family protein
XP_011096172.1bHLH family protein
XP_011096311.1bHLH family protein
XP_011096433.1bHLH family protein
XP_011096434.1bHLH family protein
XP_011096522.1bHLH family protein
XP_011096523.1bHLH family protein
XP_011096524.1bHLH family protein
XP_011096525.1bHLH family protein
XP_011096526.1bHLH family protein
XP_011096890.1bHLH family protein
XP_011097486.1bHLH family protein
XP_011097523.1bHLH family protein
XP_011097928.1bHLH family protein
XP_011097951.1bHLH family protein
XP_011098606.1bHLH family protein
XP_011098609.1bHLH family protein
XP_011098610.1bHLH family protein
XP_011098963.1bHLH family protein
XP_011099122.1bHLH family protein
XP_011099179.1bHLH family protein
XP_011099455.1bHLH family protein
XP_011099478.1bHLH family protein
XP_011099632.1bHLH family protein
XP_011099758.1bHLH family protein
XP_011099996.1bHLH family protein
XP_011100103.1bHLH family protein
XP_011100183.1bHLH family protein
XP_011100371.1bHLH family protein
XP_011100372.1bHLH family protein
XP_011100403.1bHLH family protein
XP_011100438.1bHLH family protein
XP_011101193.1bHLH family protein
XP_011102214.1bHLH family protein
XP_011102215.1bHLH family protein
XP_011102216.1bHLH family protein
XP_011102217.1bHLH family protein
XP_011102218.1bHLH family protein
XP_011102219.1bHLH family protein
XP_011102227.1bHLH family protein
XP_011102313.1bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250