PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Sesamum indicum
MIKC_MADS Family
Species TF ID Description
XP_011069761.1MIKC_MADS family protein
XP_011069762.1MIKC_MADS family protein
XP_011071241.1MIKC_MADS family protein
XP_011071269.1MIKC_MADS family protein
XP_011071972.1MIKC_MADS family protein
XP_011073080.1MIKC_MADS family protein
XP_011073081.1MIKC_MADS family protein
XP_011073634.1MIKC_MADS family protein
XP_011074282.1MIKC_MADS family protein
XP_011074633.1MIKC_MADS family protein
XP_011075339.1MIKC_MADS family protein
XP_011076262.1MIKC_MADS family protein
XP_011076263.1MIKC_MADS family protein
XP_011081162.1MIKC_MADS family protein
XP_011081947.1MIKC_MADS family protein
XP_011082936.1MIKC_MADS family protein
XP_011082938.1MIKC_MADS family protein
XP_011083640.1MIKC_MADS family protein
XP_011085305.1MIKC_MADS family protein
XP_011085306.1MIKC_MADS family protein
XP_011085307.1MIKC_MADS family protein
XP_011085308.1MIKC_MADS family protein
XP_011085309.1MIKC_MADS family protein
XP_011085591.1MIKC_MADS family protein
XP_011086821.1MIKC_MADS family protein
XP_011086822.1MIKC_MADS family protein
XP_011086823.1MIKC_MADS family protein
XP_011086825.1MIKC_MADS family protein
XP_011086917.1MIKC_MADS family protein
XP_011086918.1MIKC_MADS family protein
XP_011087945.1MIKC_MADS family protein
XP_011087946.1MIKC_MADS family protein
XP_011087974.1MIKC_MADS family protein
XP_011091217.1MIKC_MADS family protein
XP_011091774.1MIKC_MADS family protein
XP_011092451.1MIKC_MADS family protein
XP_011093185.1MIKC_MADS family protein
XP_011095942.1MIKC_MADS family protein
XP_011095997.1MIKC_MADS family protein
XP_011096010.1MIKC_MADS family protein
XP_011096018.1MIKC_MADS family protein
XP_011096026.1MIKC_MADS family protein
XP_011097479.1MIKC_MADS family protein
XP_011098072.1MIKC_MADS family protein
XP_011098073.1MIKC_MADS family protein
XP_011099040.1MIKC_MADS family protein
XP_011099041.1MIKC_MADS family protein
XP_011099043.1MIKC_MADS family protein
XP_011099465.1MIKC_MADS family protein
XP_011099987.1MIKC_MADS family protein
XP_011101156.1MIKC_MADS family protein
XP_011101157.1MIKC_MADS family protein
XP_011101158.1MIKC_MADS family protein
XP_011101160.1MIKC_MADS family protein
XP_011102153.1MIKC_MADS family protein
XP_011102154.1MIKC_MADS family protein
XP_011102155.1MIKC_MADS family protein
XP_011102220.1MIKC_MADS family protein
XP_011102237.1MIKC_MADS family protein
XP_011102244.1MIKC_MADS family protein
XP_011102249.1MIKC_MADS family protein
XP_011102259.1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513