PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Sesamum indicum
HD-ZIP Family
Species TF ID Description
XP_011085824.1HD-ZIP family protein
XP_011071017.1HD-ZIP family protein
XP_011097532.1HD-ZIP family protein
XP_011081291.1HD-ZIP family protein
XP_011098601.1HD-ZIP family protein
XP_011075470.1HD-ZIP family protein
XP_011089804.1HD-ZIP family protein
XP_011100030.1HD-ZIP family protein
XP_011075258.1HD-ZIP family protein
XP_011087055.1HD-ZIP family protein
XP_011085766.1HD-ZIP family protein
XP_011071034.1HD-ZIP family protein
XP_011086401.1HD-ZIP family protein
XP_011087214.1HD-ZIP family protein
XP_011093390.1HD-ZIP family protein
XP_011101501.1HD-ZIP family protein
XP_011073661.1HD-ZIP family protein
XP_011073660.1HD-ZIP family protein
XP_011094442.1HD-ZIP family protein
XP_011075911.1HD-ZIP family protein
XP_011087051.1HD-ZIP family protein
XP_011099420.1HD-ZIP family protein
XP_011093277.1HD-ZIP family protein
XP_011070725.1HD-ZIP family protein
XP_011099589.1HD-ZIP family protein
XP_011093009.1HD-ZIP family protein
XP_011097229.1HD-ZIP family protein
XP_011070186.1HD-ZIP family protein
XP_011075631.1HD-ZIP family protein
XP_011070385.1HD-ZIP family protein
XP_011082709.1HD-ZIP family protein
XP_011096367.1HD-ZIP family protein
XP_011086174.1HD-ZIP family protein
XP_011096101.1HD-ZIP family protein
XP_011096102.1HD-ZIP family protein
XP_011096103.1HD-ZIP family protein
XP_011072373.1HD-ZIP family protein
XP_011091721.1HD-ZIP family protein
XP_011093166.1HD-ZIP family protein
XP_011093167.1HD-ZIP family protein
XP_011076209.1HD-ZIP family protein
XP_011076210.1HD-ZIP family protein
XP_011076208.1HD-ZIP family protein
XP_011081776.1HD-ZIP family protein
XP_011080516.1HD-ZIP family protein
XP_011086973.1HD-ZIP family protein
XP_011085350.1HD-ZIP family protein
XP_011072422.1HD-ZIP family protein
XP_011072039.1HD-ZIP family protein
XP_011085207.1HD-ZIP family protein
XP_011096678.1HD-ZIP family protein
XP_011089912.1HD-ZIP family protein
XP_011089294.1HD-ZIP family protein
XP_011070329.1HD-ZIP family protein
XP_011070327.1HD-ZIP family protein
XP_011070328.1HD-ZIP family protein
XP_011085928.1HD-ZIP family protein
XP_011085929.1HD-ZIP family protein
XP_011085930.1HD-ZIP family protein
XP_011076983.1HD-ZIP family protein
XP_011076980.1HD-ZIP family protein
XP_011076981.1HD-ZIP family protein
XP_011084331.1HD-ZIP family protein
XP_011084330.1HD-ZIP family protein
XP_011084333.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401