PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Raphanus raphanistrum
bHLH Family
Species TF ID Description
RrC10086_p1bHLH family protein
RrC1008_p2bHLH family protein
RrC10199_p1bHLH family protein
RrC10483_p1bHLH family protein
RrC10578_p1bHLH family protein
RrC10676_p1bHLH family protein
RrC10775_p1bHLH family protein
RrC108_p4bHLH family protein
RrC10958_p1bHLH family protein
RrC11033_p1bHLH family protein
RrC11065_p1bHLH family protein
RrC11268_p1bHLH family protein
RrC11277_p1bHLH family protein
RrC1130_p1bHLH family protein
RrC11369_p1bHLH family protein
RrC11458_p1bHLH family protein
RrC1146_p3bHLH family protein
RrC11642_p1bHLH family protein
RrC11742_p1bHLH family protein
RrC11779_p1bHLH family protein
RrC1210_p5bHLH family protein
RrC12162_p1bHLH family protein
RrC1216_p4bHLH family protein
RrC1223_p2bHLH family protein
RrC12416_p1bHLH family protein
RrC1254_p2bHLH family protein
RrC1259_p1bHLH family protein
RrC12681_p1bHLH family protein
RrC1278_p2bHLH family protein
RrC12925_p1bHLH family protein
RrC13052_p1bHLH family protein
RrC13114_p1bHLH family protein
RrC13544_p2bHLH family protein
RrC13565_p1bHLH family protein
RrC13578_p1bHLH family protein
RrC1360_p3bHLH family protein
RrC13645_p2bHLH family protein
RrC1366_p2bHLH family protein
RrC13867_p1bHLH family protein
RrC1406_p1bHLH family protein
RrC14586_p1bHLH family protein
RrC1458_p1bHLH family protein
RrC1486_p3bHLH family protein
RrC148_p5bHLH family protein
RrC15175_p1bHLH family protein
RrC1524_p3bHLH family protein
RrC156_p14bHLH family protein
RrC156_p15bHLH family protein
RrC1570_p1bHLH family protein
RrC15743_p2bHLH family protein
RrC15911_p1bHLH family protein
RrC16060_p1bHLH family protein
RrC1631_p3bHLH family protein
RrC164_p11bHLH family protein
RrC16589_p1bHLH family protein
RrC16619_p1bHLH family protein
RrC1666_p1bHLH family protein
RrC16674_p2bHLH family protein
RrC16987_p1bHLH family protein
RrC17085_p1bHLH family protein
RrC170_p12bHLH family protein
RrC17143_p1bHLH family protein
RrC1722_p2bHLH family protein
RrC17293_p1bHLH family protein
RrC17536_p1bHLH family protein
RrC1757_p5bHLH family protein
RrC18427_p1bHLH family protein
RrC18477_p1bHLH family protein
RrC184_p6bHLH family protein
RrC186_p2bHLH family protein
RrC1871_p5bHLH family protein
RrC19048_p1bHLH family protein
RrC19071_p1bHLH family protein
RrC19206_p1bHLH family protein
RrC19496_p1bHLH family protein
RrC1984_p3bHLH family protein
RrC1987_p2bHLH family protein
RrC20195_p1bHLH family protein
RrC216_p2bHLH family protein
RrC21780_p1bHLH family protein
RrC21801_p1bHLH family protein
RrC2202_p4bHLH family protein
RrC2220_p2bHLH family protein
RrC22724_p1bHLH family protein
RrC2274_p1bHLH family protein
RrC2300_p5bHLH family protein
RrC23068_p1bHLH family protein
RrC23113_p1bHLH family protein
RrC2348_p3bHLH family protein
RrC23588_p1bHLH family protein
RrC23716_p1bHLH family protein
RrC2388_p6bHLH family protein
RrC2403_p2bHLH family protein
RrC241_p8bHLH family protein
RrC2433_p6bHLH family protein
RrC24680_p1bHLH family protein
RrC24875_p1bHLH family protein
RrC24973_p1bHLH family protein
RrC25023_p1bHLH family protein
RrC2506_p2bHLH family protein
RrC2513_p1bHLH family protein
RrC2517_p6bHLH family protein
RrC2535_p1bHLH family protein
RrC2554_p3bHLH family protein
RrC2601_p2bHLH family protein
RrC2604_p3bHLH family protein
RrC2618_p3bHLH family protein
RrC26490_p1bHLH family protein
RrC2673_p3bHLH family protein
RrC2777_p2bHLH family protein
RrC2778_p2bHLH family protein
RrC2778_p5bHLH family protein
RrC28165_p1bHLH family protein
RrC28822_p1bHLH family protein
RrC2891_p2bHLH family protein
RrC2961_p3bHLH family protein
RrC3017_p5bHLH family protein
RrC301_p9bHLH family protein
RrC3039_p2bHLH family protein
RrC3065_p2bHLH family protein
RrC30807_p1bHLH family protein
RrC3150_p2bHLH family protein
RrC3268_p2bHLH family protein
RrC338_p1bHLH family protein
RrC3431_p3bHLH family protein
RrC34520_p1bHLH family protein
RrC3473_p1bHLH family protein
RrC3517_p4bHLH family protein
RrC351_p2bHLH family protein
RrC3740_p3bHLH family protein
RrC378_p8bHLH family protein
RrC37_p11bHLH family protein
RrC3826_p3bHLH family protein
RrC3848_p1bHLH family protein
RrC3960_p2bHLH family protein
RrC3963_p1bHLH family protein
RrC416_p9bHLH family protein
RrC4222_p3bHLH family protein
RrC4247_p4bHLH family protein
RrC4284_p1bHLH family protein
RrC43_p17bHLH family protein
RrC4438_p3bHLH family protein
RrC455_p7bHLH family protein
RrC456_p7bHLH family protein
RrC4586_p1bHLH family protein
RrC4697_p2bHLH family protein
RrC469_p3bHLH family protein
RrC4702_p1bHLH family protein
RrC4911_p2bHLH family protein
RrC49_p8bHLH family protein
RrC5024_p1bHLH family protein
RrC5129_p2bHLH family protein
RrC5222_p1bHLH family protein
RrC5237_p1bHLH family protein
RrC5257_p1bHLH family protein
RrC5274_p1bHLH family protein
RrC5275_p1bHLH family protein
RrC5306_p2bHLH family protein
RrC5373_p1bHLH family protein
RrC5379_p3bHLH family protein
RrC5416_p5bHLH family protein
RrC54508_p1bHLH family protein
RrC5475_p1bHLH family protein
RrC5519_p2bHLH family protein
RrC5562_p1bHLH family protein
RrC55_p12bHLH family protein
RrC5686_p1bHLH family protein
RrC5822_p1bHLH family protein
RrC583_p4bHLH family protein
RrC5869_p2bHLH family protein
RrC5921_p1bHLH family protein
RrC60080_p1bHLH family protein
RrC603_p3bHLH family protein
RrC6062_p1bHLH family protein
RrC6081_p1bHLH family protein
RrC6105_p1bHLH family protein
RrC6121_p1bHLH family protein
RrC63_p16bHLH family protein
RrC650_p3bHLH family protein
RrC656_p2bHLH family protein
RrC6651_p1bHLH family protein
RrC6658_p1bHLH family protein
RrC6757_p1bHLH family protein
RrC6792_p1bHLH family protein
RrC7016_p1bHLH family protein
RrC7024_p1bHLH family protein
RrC7070_p1bHLH family protein
RrC715_p1bHLH family protein
RrC7233_p1bHLH family protein
RrC7292_p1bHLH family protein
RrC7295_p1bHLH family protein
RrC7372_p1bHLH family protein
RrC744_p2bHLH family protein
RrC7488_p3bHLH family protein
RrC7494_p1bHLH family protein
RrC770_p4bHLH family protein
RrC7777_p1bHLH family protein
RrC7798_p1bHLH family protein
RrC784_p2bHLH family protein
RrC784_p8bHLH family protein
RrC7859_p2bHLH family protein
RrC7880_p2bHLH family protein
RrC796_p6bHLH family protein
RrC7996_p1bHLH family protein
RrC8143_p2bHLH family protein
RrC8165_p3bHLH family protein
RrC8172_p2bHLH family protein
RrC8195_p1bHLH family protein
RrC8230_p1bHLH family protein
RrC8419_p2bHLH family protein
RrC8431_p1bHLH family protein
RrC844_p1bHLH family protein
RrC8589_p1bHLH family protein
RrC8698_p2bHLH family protein
RrC87_p12bHLH family protein
RrC8900_p1bHLH family protein
RrC8933_p1bHLH family protein
RrC9029_p1bHLH family protein
RrC9086_p3bHLH family protein
RrC9178_p3bHLH family protein
RrC9239_p1bHLH family protein
RrC92_p3bHLH family protein
RrC9462_p1bHLH family protein
RrC9504_p1bHLH family protein
RrC9511_p2bHLH family protein
RrC9511_p3bHLH family protein
RrC9582_p1bHLH family protein
RrC961_p8bHLH family protein
RrC9679_p1bHLH family protein
RrC975_p2bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250