PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Raphanus raphanistrum
M-type_MADS Family
Species TF ID Description
RrC10807_p2M-type_MADS family protein
RrC10931_p2M-type_MADS family protein
RrC11525_p1M-type_MADS family protein
RrC1183_p2M-type_MADS family protein
RrC12115_p1M-type_MADS family protein
RrC12231_p5M-type_MADS family protein
RrC12469_p1M-type_MADS family protein
RrC12830_p1M-type_MADS family protein
RrC13082_p1M-type_MADS family protein
RrC13371_p1M-type_MADS family protein
RrC13838_p1M-type_MADS family protein
RrC1496_p1M-type_MADS family protein
RrC1763_p1M-type_MADS family protein
RrC17785_p1M-type_MADS family protein
RrC1783_p2M-type_MADS family protein
RrC19123_p1M-type_MADS family protein
RrC19294_p1M-type_MADS family protein
RrC1970_p2M-type_MADS family protein
RrC20252_p1M-type_MADS family protein
RrC2055_p5M-type_MADS family protein
RrC2096_p5M-type_MADS family protein
RrC21298_p1M-type_MADS family protein
RrC212_p4M-type_MADS family protein
RrC22842_p1M-type_MADS family protein
RrC23124_p1M-type_MADS family protein
RrC23437_p2M-type_MADS family protein
RrC24709_p1M-type_MADS family protein
RrC2482_p5M-type_MADS family protein
RrC26244_p1M-type_MADS family protein
RrC27450_p1M-type_MADS family protein
RrC27859_p1M-type_MADS family protein
RrC28432_p1M-type_MADS family protein
RrC29350_p1M-type_MADS family protein
RrC3079_p2M-type_MADS family protein
RrC30821_p1M-type_MADS family protein
RrC3265_p1M-type_MADS family protein
RrC3291_p2M-type_MADS family protein
RrC3302_p3M-type_MADS family protein
RrC3302_p4M-type_MADS family protein
RrC3377_p2M-type_MADS family protein
RrC36717_p1M-type_MADS family protein
RrC370_p4M-type_MADS family protein
RrC3851_p1M-type_MADS family protein
RrC38630_p1M-type_MADS family protein
RrC39330_p1M-type_MADS family protein
RrC4032_p4M-type_MADS family protein
RrC4073_p2M-type_MADS family protein
RrC4247_p1M-type_MADS family protein
RrC4249_p1M-type_MADS family protein
RrC42715_p1M-type_MADS family protein
RrC4360_p1M-type_MADS family protein
RrC4790_p1M-type_MADS family protein
RrC4841_p1M-type_MADS family protein
RrC49560_p1M-type_MADS family protein
RrC5014_p1M-type_MADS family protein
RrC5633_p4M-type_MADS family protein
RrC578_p3M-type_MADS family protein
RrC5887_p3M-type_MADS family protein
RrC5951_p2M-type_MADS family protein
RrC6078_p4M-type_MADS family protein
RrC6079_p1M-type_MADS family protein
RrC6091_p1M-type_MADS family protein
RrC6340_p3M-type_MADS family protein
RrC6527_p1M-type_MADS family protein
RrC6615_p2M-type_MADS family protein
RrC688_p6M-type_MADS family protein
RrC7133_p1M-type_MADS family protein
RrC7195_p3M-type_MADS family protein
RrC7993_p1M-type_MADS family protein
RrC7993_p2M-type_MADS family protein
RrC841_p5M-type_MADS family protein
RrC8572_p1M-type_MADS family protein
RrC8749_p1M-type_MADS family protein
RrC877_p4M-type_MADS family protein
RrC9040_p1M-type_MADS family protein
RrC9299_p1M-type_MADS family protein
RrC9497_p1M-type_MADS family protein
RrC9579_p1M-type_MADS family protein
RrC9964_p1M-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513