PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Raphanus raphanistrum
HD-ZIP Family
Species TF ID Description
RrC4473_p1HD-ZIP family protein
RrC23998_p1HD-ZIP family protein
RrC5542_p2HD-ZIP family protein
RrC547_p1HD-ZIP family protein
RrC19245_p1HD-ZIP family protein
RrC1631_p2HD-ZIP family protein
RrC4252_p3HD-ZIP family protein
RrC2387_p1HD-ZIP family protein
RrC3392_p1HD-ZIP family protein
RrC2708_p1HD-ZIP family protein
RrC7376_p2HD-ZIP family protein
RrC17361_p1HD-ZIP family protein
RrC11078_p1HD-ZIP family protein
RrC18890_p1HD-ZIP family protein
RrC1233_p1HD-ZIP family protein
RrC9430_p1HD-ZIP family protein
RrC8416_p2HD-ZIP family protein
RrC5602_p1HD-ZIP family protein
RrC6257_p2HD-ZIP family protein
RrC1374_p5HD-ZIP family protein
RrC9240_p1HD-ZIP family protein
RrC14295_p1HD-ZIP family protein
RrC131_p10HD-ZIP family protein
RrC1092_p1HD-ZIP family protein
RrC14541_p1HD-ZIP family protein
RrC614_p1HD-ZIP family protein
RrC7304_p1HD-ZIP family protein
RrC6022_p2HD-ZIP family protein
RrC305_p3HD-ZIP family protein
RrC13539_p1HD-ZIP family protein
RrC1693_p2HD-ZIP family protein
RrC16353_p1HD-ZIP family protein
RrC42628_p1HD-ZIP family protein
RrC6305_p1HD-ZIP family protein
RrC5809_p3HD-ZIP family protein
RrC624_p9HD-ZIP family protein
RrC5890_p1HD-ZIP family protein
RrC4816_p1HD-ZIP family protein
RrC1659_p1HD-ZIP family protein
RrC2237_p4HD-ZIP family protein
RrC267_p3HD-ZIP family protein
RrC8299_p1HD-ZIP family protein
RrC2237_p3HD-ZIP family protein
RrC342_p9HD-ZIP family protein
RrC1_p11HD-ZIP family protein
RrC20516_p1HD-ZIP family protein
RrC10936_p1HD-ZIP family protein
RrC1566_p2HD-ZIP family protein
RrC17403_p1HD-ZIP family protein
RrC2640_p2HD-ZIP family protein
RrC1897_p1HD-ZIP family protein
RrC7332_p1HD-ZIP family protein
RrC969_p7HD-ZIP family protein
RrC4900_p1HD-ZIP family protein
RrC2185_p4HD-ZIP family protein
RrC8510_p2HD-ZIP family protein
RrC810_p1HD-ZIP family protein
RrC3081_p3HD-ZIP family protein
RrC450_p2HD-ZIP family protein
RrC911_p1HD-ZIP family protein
RrC974_p5HD-ZIP family protein
RrC3602_p1HD-ZIP family protein
RrC5949_p1HD-ZIP family protein
RrC5826_p3HD-ZIP family protein
RrC142_p8HD-ZIP family protein
RrC1605_p5HD-ZIP family protein
RrC3092_p1HD-ZIP family protein
RrC12745_p1HD-ZIP family protein
RrC1476_p2HD-ZIP family protein
RrC2365_p2HD-ZIP family protein
RrC2546_p2HD-ZIP family protein
RrC12371_p1HD-ZIP family protein
RrC13422_p1HD-ZIP family protein
RrC3699_p2HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401