PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Ricinus communis
HD-ZIP Family
Species TF ID Description
29822.m003350HD-ZIP family protein
29736.m002010HD-ZIP family protein
29822.m003500HD-ZIP family protein
30226.m002015HD-ZIP family protein
30147.m014069HD-ZIP family protein
28578.m000034HD-ZIP family protein
29908.m006082HD-ZIP family protein
30174.m008775HD-ZIP family protein
29736.m002045HD-ZIP family protein
29825.m000313HD-ZIP family protein
30170.m013648HD-ZIP family protein
27964.m000347HD-ZIP family protein
29662.m000460HD-ZIP family protein
29816.m000678HD-ZIP family protein
30089.m001006HD-ZIP family protein
29815.m000499HD-ZIP family protein
29646.m001066HD-ZIP family protein
27401.m000280HD-ZIP family protein
28307.m000017HD-ZIP family protein
29983.m003123HD-ZIP family protein
30146.m003568HD-ZIP family protein
29600.m000538HD-ZIP family protein
29842.m003633HD-ZIP family protein
30174.m008969HD-ZIP family protein
30147.m014288HD-ZIP family protein
30075.m001183HD-ZIP family protein
30135.m000188HD-ZIP family protein
30146.m003520HD-ZIP family protein
29794.m003393HD-ZIP family protein
27538.m000332HD-ZIP family protein
30068.m002643HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401