PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Physcomitrella patens
HD-ZIP Family
Species TF ID Description
Pp3c2_4940V3.7.pHD-ZIP family protein
Pp3c2_4940V3.2.pHD-ZIP family protein
Pp3c2_4940V3.3.pHD-ZIP family protein
Pp3c2_4940V3.8.pHD-ZIP family protein
Pp3c2_4940V3.1.pHD-ZIP family protein
Pp3c2_4940V3.4.pHD-ZIP family protein
Pp3c2_4940V3.5.pHD-ZIP family protein
Pp3c2_4940V3.6.pHD-ZIP family protein
Pp3c11_21670V3.1.pHD-ZIP family protein
Pp3c11_21670V3.2.pHD-ZIP family protein
Pp3c7_6890V3.1.pHD-ZIP family protein
Pp3c7_6890V3.2.pHD-ZIP family protein
Pp3c7_6850V3.1.pHD-ZIP family protein
Pp3c7_6850V3.2.pHD-ZIP family protein
Pp3c11_21650V3.1.pHD-ZIP family protein
Pp3c11_21650V3.2.pHD-ZIP family protein
Pp3c11_23440V3.1.pHD-ZIP family protein
Pp3c11_23440V3.2.pHD-ZIP family protein
Pp3c17_18190V3.4.pHD-ZIP family protein
Pp3c17_18190V3.3.pHD-ZIP family protein
Pp3c17_18190V3.5.pHD-ZIP family protein
Pp3c25_13450V3.1.pHD-ZIP family protein
Pp3c25_13450V3.2.pHD-ZIP family protein
Pp3c6_2730V3.1.pHD-ZIP family protein
Pp3c6_2730V3.2.pHD-ZIP family protein
Pp3c17_18190V3.1.pHD-ZIP family protein
Pp3c17_18190V3.2.pHD-ZIP family protein
Pp3c12_21760V3.1.pHD-ZIP family protein
Pp3c12_21760V3.2.pHD-ZIP family protein
Pp3c12_21760V3.3.pHD-ZIP family protein
Pp3c12_21760V3.4.pHD-ZIP family protein
Pp3c7_2100V3.1.pHD-ZIP family protein
Pp3c7_2100V3.2.pHD-ZIP family protein
Pp3c3_37710V3.1.pHD-ZIP family protein
Pp3c3_37710V3.2.pHD-ZIP family protein
Pp3c3_37710V3.3.pHD-ZIP family protein
Pp3c3_37710V3.4.pHD-ZIP family protein
Pp3c5_27150V3.4.pHD-ZIP family protein
Pp3c4_7260V3.1.pHD-ZIP family protein
Pp3c4_7260V3.2.pHD-ZIP family protein
Pp3c5_27150V3.1.pHD-ZIP family protein
Pp3c5_27150V3.2.pHD-ZIP family protein
Pp3c5_27150V3.3.pHD-ZIP family protein
Pp3c14_21620V3.2.pHD-ZIP family protein
Pp3c17_18130V3.1.pHD-ZIP family protein
Pp3c17_18130V3.2.pHD-ZIP family protein
Pp3c17_18130V3.3.pHD-ZIP family protein
Pp3c17_18130V3.4.pHD-ZIP family protein
Pp3c14_21620V3.1.pHD-ZIP family protein
Pp3c14_21620V3.3.pHD-ZIP family protein
Pp3c16_21410V3.1.pHD-ZIP family protein
Pp3c16_21410V3.2.pHD-ZIP family protein
Pp3c8_440V3.1.pHD-ZIP family protein
Pp3c8_440V3.2.pHD-ZIP family protein
Pp3c8_440V3.3.pHD-ZIP family protein
Pp3c8_440V3.4.pHD-ZIP family protein
Pp3c8_440V3.5.pHD-ZIP family protein
Pp3c1_36940V3.1.pHD-ZIP family protein
Pp3c1_36940V3.2.pHD-ZIP family protein
Pp3c1_37070V3.1.pHD-ZIP family protein
Pp3c1_37070V3.2.pHD-ZIP family protein
Pp3c14_21680V3.1.pHD-ZIP family protein
Pp3c14_21680V3.2.pHD-ZIP family protein
Pp3c15_21200V3.1.pHD-ZIP family protein
Pp3c15_21200V3.2.pHD-ZIP family protein
Pp3c5_6470V3.8.pHD-ZIP family protein
Pp3c5_6470V3.1.pHD-ZIP family protein
Pp3c5_6470V3.2.pHD-ZIP family protein
Pp3c5_6470V3.3.pHD-ZIP family protein
Pp3c5_6470V3.4.pHD-ZIP family protein
Pp3c5_6470V3.5.pHD-ZIP family protein
Pp3c5_6470V3.6.pHD-ZIP family protein
Pp3c5_6470V3.7.pHD-ZIP family protein
Pp3c5_6470V3.9.pHD-ZIP family protein
Pp3c15_21200V3.3.pHD-ZIP family protein
Pp3c9_22420V3.1.pHD-ZIP family protein
Pp3c9_22420V3.2.pHD-ZIP family protein
Pp3c9_22420V3.3.pHD-ZIP family protein
Pp3c9_22420V3.4.pHD-ZIP family protein
Pp3c9_22420V3.5.pHD-ZIP family protein
Pp3c9_22420V3.6.pHD-ZIP family protein
Pp3c9_22420V3.7.pHD-ZIP family protein
Pp3c6_26770V3.1.pHD-ZIP family protein
Pp3c6_26770V3.2.pHD-ZIP family protein
Pp3c6_26770V3.3.pHD-ZIP family protein
Pp3c6_26770V3.4.pHD-ZIP family protein
Pp3c6_26770V3.5.pHD-ZIP family protein
Pp3c17_16910V3.1.pHD-ZIP family protein
Pp3c17_16910V3.2.pHD-ZIP family protein
Pp3c17_16910V3.3.pHD-ZIP family protein
Pp3c17_16910V3.4.pHD-ZIP family protein
Pp3c17_16910V3.5.pHD-ZIP family protein
Pp3c14_15980V3.1.pHD-ZIP family protein
Pp3c14_15980V3.3.pHD-ZIP family protein
Pp3c14_15980V3.2.pHD-ZIP family protein
Pp3c2_10790V3.2.pHD-ZIP family protein
Pp3c2_10790V3.1.pHD-ZIP family protein
Pp3c1_24020V3.1.pHD-ZIP family protein
Pp3c16_15450V3.1.pHD-ZIP family protein
Pp3c16_15450V3.3.pHD-ZIP family protein
Pp3c16_15450V3.4.pHD-ZIP family protein
Pp3c16_15450V3.2.pHD-ZIP family protein
Pp3c10_19630V3.10.pHD-ZIP family protein
Pp3c10_19630V3.1.pHD-ZIP family protein
Pp3c10_19630V3.11.pHD-ZIP family protein
Pp3c10_19630V3.2.pHD-ZIP family protein
Pp3c10_19630V3.3.pHD-ZIP family protein
Pp3c10_19630V3.5.pHD-ZIP family protein
Pp3c10_19630V3.6.pHD-ZIP family protein
Pp3c10_19630V3.7.pHD-ZIP family protein
Pp3c10_19630V3.8.pHD-ZIP family protein
Pp3c10_19630V3.9.pHD-ZIP family protein
Pp3c10_19630V3.4.pHD-ZIP family protein
Pp3c12_14370V3.1.pHD-ZIP family protein
Pp3c12_14370V3.2.pHD-ZIP family protein
Pp3c12_14370V3.3.pHD-ZIP family protein
Pp3c12_14370V3.4.pHD-ZIP family protein
Pp3c12_14370V3.7.pHD-ZIP family protein
Pp3c12_14370V3.5.pHD-ZIP family protein
Pp3c12_14370V3.6.pHD-ZIP family protein
Pp3c3_30010V3.1.pHD-ZIP family protein
Pp3c3_30010V3.3.pHD-ZIP family protein
Pp3c3_30010V3.10.pHD-ZIP family protein
Pp3c3_30010V3.4.pHD-ZIP family protein
Pp3c3_30010V3.5.pHD-ZIP family protein
Pp3c3_30010V3.9.pHD-ZIP family protein
Pp3c3_30010V3.8.pHD-ZIP family protein
Pp3c3_30010V3.7.pHD-ZIP family protein
Pp3c3_30010V3.6.pHD-ZIP family protein
Pp3c4_5300V3.1.pHD-ZIP family protein
Pp3c4_5300V3.5.pHD-ZIP family protein
Pp3c4_5300V3.6.pHD-ZIP family protein
Pp3c4_5300V3.2.pHD-ZIP family protein
Pp3c4_5300V3.3.pHD-ZIP family protein
Pp3c4_5300V3.4.pHD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401