PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Prunus mume
bHLH Family
Species TF ID Description
XP_008218265.1bHLH family protein
XP_008218266.1bHLH family protein
XP_008219008.1bHLH family protein
XP_008219184.1bHLH family protein
XP_008219331.1bHLH family protein
XP_008219358.1bHLH family protein
XP_008220346.1bHLH family protein
XP_008220363.1bHLH family protein
XP_008220406.1bHLH family protein
XP_008220407.1bHLH family protein
XP_008220408.1bHLH family protein
XP_008220847.1bHLH family protein
XP_008220848.1bHLH family protein
XP_008220849.1bHLH family protein
XP_008221374.1bHLH family protein
XP_008221650.1bHLH family protein
XP_008221651.1bHLH family protein
XP_008221713.1bHLH family protein
XP_008221870.1bHLH family protein
XP_008222403.1bHLH family protein
XP_008222500.1bHLH family protein
XP_008222502.1bHLH family protein
XP_008222661.1bHLH family protein
XP_008222784.1bHLH family protein
XP_008223133.1bHLH family protein
XP_008223870.1bHLH family protein
XP_008224372.1bHLH family protein
XP_008224428.1bHLH family protein
XP_008224493.1bHLH family protein
XP_008224494.1bHLH family protein
XP_008224874.1bHLH family protein
XP_008224893.1bHLH family protein
XP_008224894.1bHLH family protein
XP_008224896.1bHLH family protein
XP_008225174.1bHLH family protein
XP_008225271.1bHLH family protein
XP_008225759.1bHLH family protein
XP_008226618.1bHLH family protein
XP_008226756.1bHLH family protein
XP_008228480.1bHLH family protein
XP_008228481.1bHLH family protein
XP_008228482.1bHLH family protein
XP_008228998.1bHLH family protein
XP_008229223.1bHLH family protein
XP_008229596.2bHLH family protein
XP_008230307.1bHLH family protein
XP_008230308.1bHLH family protein
XP_008230751.1bHLH family protein
XP_008231033.1bHLH family protein
XP_008231356.1bHLH family protein
XP_008231650.2bHLH family protein
XP_008232566.1bHLH family protein
XP_008232900.1bHLH family protein
XP_008233131.1bHLH family protein
XP_008233781.1bHLH family protein
XP_008234323.1bHLH family protein
XP_008234325.1bHLH family protein
XP_008234326.1bHLH family protein
XP_008234327.1bHLH family protein
XP_008234779.2bHLH family protein
XP_008235249.1bHLH family protein
XP_008235250.1bHLH family protein
XP_008235251.1bHLH family protein
XP_008235259.1bHLH family protein
XP_008235271.1bHLH family protein
XP_008235331.1bHLH family protein
XP_008235541.1bHLH family protein
XP_008235701.1bHLH family protein
XP_008235702.1bHLH family protein
XP_008235723.1bHLH family protein
XP_008236124.1bHLH family protein
XP_008236173.1bHLH family protein
XP_008236198.1bHLH family protein
XP_008236358.1bHLH family protein
XP_008236359.1bHLH family protein
XP_008236390.1bHLH family protein
XP_008236491.1bHLH family protein
XP_008236674.1bHLH family protein
XP_008236876.1bHLH family protein
XP_008236887.1bHLH family protein
XP_008236908.1bHLH family protein
XP_008238226.1bHLH family protein
XP_008238247.1bHLH family protein
XP_008238754.1bHLH family protein
XP_008238755.1bHLH family protein
XP_008238769.1bHLH family protein
XP_008238828.1bHLH family protein
XP_008239542.1bHLH family protein
XP_008239552.1bHLH family protein
XP_008239676.1bHLH family protein
XP_008239749.1bHLH family protein
XP_008239750.1bHLH family protein
XP_008239751.1bHLH family protein
XP_008239804.1bHLH family protein
XP_008239805.1bHLH family protein
XP_008239815.1bHLH family protein
XP_008240068.1bHLH family protein
XP_008240069.1bHLH family protein
XP_008240071.1bHLH family protein
XP_008240256.1bHLH family protein
XP_008240669.1bHLH family protein
XP_008240817.1bHLH family protein
XP_008240829.1bHLH family protein
XP_008241478.1bHLH family protein
XP_008241480.1bHLH family protein
XP_008241481.1bHLH family protein
XP_008241488.2bHLH family protein
XP_008241823.1bHLH family protein
XP_008242151.1bHLH family protein
XP_008242363.1bHLH family protein
XP_008242571.1bHLH family protein
XP_008242964.1bHLH family protein
XP_008243129.1bHLH family protein
XP_008243130.1bHLH family protein
XP_008243163.1bHLH family protein
XP_008243251.1bHLH family protein
XP_008243252.1bHLH family protein
XP_008243253.1bHLH family protein
XP_008243254.1bHLH family protein
XP_008243279.1bHLH family protein
XP_008243775.2bHLH family protein
XP_008243794.1bHLH family protein
XP_008243989.1bHLH family protein
XP_008244210.1bHLH family protein
XP_008244684.1bHLH family protein
XP_008244773.1bHLH family protein
XP_008244842.1bHLH family protein
XP_008245174.1bHLH family protein
XP_008245180.1bHLH family protein
XP_008245384.1bHLH family protein
XP_008245385.1bHLH family protein
XP_008245386.1bHLH family protein
XP_008245390.1bHLH family protein
XP_008245834.1bHLH family protein
XP_008245935.1bHLH family protein
XP_008245936.1bHLH family protein
XP_008246329.1bHLH family protein
XP_008246511.1bHLH family protein
XP_016647633.1bHLH family protein
XP_016647805.1bHLH family protein
XP_016647807.1bHLH family protein
XP_016647808.1bHLH family protein
XP_016648145.1bHLH family protein
XP_016649113.1bHLH family protein
XP_016649255.1bHLH family protein
XP_016649885.1bHLH family protein
XP_016649886.1bHLH family protein
XP_016649887.1bHLH family protein
XP_016649888.1bHLH family protein
XP_016649889.1bHLH family protein
XP_016649890.1bHLH family protein
XP_016650411.1bHLH family protein
XP_016650643.1bHLH family protein
XP_016650919.1bHLH family protein
XP_016651050.1bHLH family protein
XP_016651146.1bHLH family protein
XP_016651277.1bHLH family protein
XP_016651278.1bHLH family protein
XP_016651309.1bHLH family protein
XP_016651429.1bHLH family protein
XP_016651480.1bHLH family protein
XP_016652303.1bHLH family protein
XP_016652557.1bHLH family protein
XP_016652703.1bHLH family protein
XP_016652732.1bHLH family protein
bHLH Family Introduction

The basic/helix-loop-helix (bHLH) proteins are a superfamily of transcription factors that have been well characterized in nonplant eukaryotes, especially in mammalian systems, in which considerable structural, functional, and phylogenetic analyses have been performed. The data indicate that bHLH proteins are important regulatory components in transcriptional networks in these systems, controlling a diversity of processes from cell proliferation to cell lineage establishment.

This family is defined by the bHLH signature domain, which consists of 60 amino acids with two functionally distinct regions. The basic region, located at the N-terminal end of the domain, is involved in DNA binding and consists of 15 amino acids with a high number of basic residues. The HLH region, at the C-terminal end, functions as a dimerization domain and is constituted mainly of hydrophobic residues that form two amphipathic -helices separated by a loop region of variable sequence and length. Outside of the conserved bHLH domain, these proteins exhibit considerable sequence divergence. Cocrystal structural analysis has shown that the interaction between the HLH regions of two separate polypeptides leads to the formation of homodimers and/or heterodimers and that the basic region of each partner binds to half of the DNA recognition sequence. Some bHLH proteins form homodimers or restrict their heterodimerization activity to closely related members of the family. On the other hand, some can form heterodimers with one or several different partners.

The core DNA sequence motif recognized by the bHLH proteins is a consensus hexanucleotide sequence known as the E-box (5'-CANNTG-3'). There are different types of E-boxes, depending on the identity of the two central bases. One of the most common is the palindromic G-box (5'-CACGTG-3'). Certain conserved amino acids within the basic region of the protein provide recognition of the core consensus site, whereas other residues in the domain dictate specificity for a given type of E-box . In addition, flanking nucleotides outside of the hexanucleotide core have been shown to play a role in binding specificity, and there is evidence that a loop residue in the protein plays a role in DNA binding through elements that lie outside of the core recognition sequence.

Toledo-Ortiz G, Huq E, Quail PH.
The Arabidopsis basic/helix-loop-helix transcription factor family.
Plant Cell. 2003 Aug;15(8):1749-70
PMID: 12897250