PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Prunus mume
MIKC_MADS Family
Species TF ID Description
NP_001280191.1MIKC_MADS family protein
NP_001280193.1MIKC_MADS family protein
NP_001280194.1MIKC_MADS family protein
NP_001280195.1MIKC_MADS family protein
NP_001280196.1MIKC_MADS family protein
NP_001280197.1MIKC_MADS family protein
NP_001306730.1MIKC_MADS family protein
NP_001306731.1MIKC_MADS family protein
XP_008219057.1MIKC_MADS family protein
XP_008219059.1MIKC_MADS family protein
XP_008219077.1MIKC_MADS family protein
XP_008219192.1MIKC_MADS family protein
XP_008219193.1MIKC_MADS family protein
XP_008219194.1MIKC_MADS family protein
XP_008219269.1MIKC_MADS family protein
XP_008219270.1MIKC_MADS family protein
XP_008219271.1MIKC_MADS family protein
XP_008219272.1MIKC_MADS family protein
XP_008219575.1MIKC_MADS family protein
XP_008221326.2MIKC_MADS family protein
XP_008222191.1MIKC_MADS family protein
XP_008225406.1MIKC_MADS family protein
XP_008225407.1MIKC_MADS family protein
XP_008225408.1MIKC_MADS family protein
XP_008225409.1MIKC_MADS family protein
XP_008225840.1MIKC_MADS family protein
XP_008225841.1MIKC_MADS family protein
XP_008225844.1MIKC_MADS family protein
XP_008225845.1MIKC_MADS family protein
XP_008230289.1MIKC_MADS family protein
XP_008230290.1MIKC_MADS family protein
XP_008230291.1MIKC_MADS family protein
XP_008230292.1MIKC_MADS family protein
XP_008230294.1MIKC_MADS family protein
XP_008231099.1MIKC_MADS family protein
XP_008231548.1MIKC_MADS family protein
XP_008232833.1MIKC_MADS family protein
XP_008232835.1MIKC_MADS family protein
XP_008233985.1MIKC_MADS family protein
XP_008234477.1MIKC_MADS family protein
XP_008235579.1MIKC_MADS family protein
XP_008235586.1MIKC_MADS family protein
XP_008235594.1MIKC_MADS family protein
XP_008235603.1MIKC_MADS family protein
XP_008236592.1MIKC_MADS family protein
XP_008237086.1MIKC_MADS family protein
XP_008237141.1MIKC_MADS family protein
XP_008237142.1MIKC_MADS family protein
XP_008237143.1MIKC_MADS family protein
XP_008237144.1MIKC_MADS family protein
XP_008237145.1MIKC_MADS family protein
XP_008239493.1MIKC_MADS family protein
XP_008240080.1MIKC_MADS family protein
XP_008240081.1MIKC_MADS family protein
XP_008240082.1MIKC_MADS family protein
XP_008241773.1MIKC_MADS family protein
XP_008241774.1MIKC_MADS family protein
XP_008243811.1MIKC_MADS family protein
XP_008243812.1MIKC_MADS family protein
XP_008243813.1MIKC_MADS family protein
XP_008243814.1MIKC_MADS family protein
XP_008243815.1MIKC_MADS family protein
XP_008243816.1MIKC_MADS family protein
XP_008244251.1MIKC_MADS family protein
XP_016646849.1MIKC_MADS family protein
XP_016646850.1MIKC_MADS family protein
XP_016646851.1MIKC_MADS family protein
XP_016647215.1MIKC_MADS family protein
XP_016648485.1MIKC_MADS family protein
XP_016648725.1MIKC_MADS family protein
XP_016649470.1MIKC_MADS family protein
XP_016649582.1MIKC_MADS family protein
XP_016649927.1MIKC_MADS family protein
XP_016649947.1MIKC_MADS family protein
XP_016649948.1MIKC_MADS family protein
XP_016649949.1MIKC_MADS family protein
XP_016650154.1MIKC_MADS family protein
XP_016650260.1MIKC_MADS family protein
XP_016650261.1MIKC_MADS family protein
XP_016650554.1MIKC_MADS family protein
XP_016650555.1MIKC_MADS family protein
XP_016650556.1MIKC_MADS family protein
XP_016650557.1MIKC_MADS family protein
XP_016650834.1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513