Plant Transcription Factor Database
Previous version: v1.0, v2.0, v3.0
Prunus mume
HD-ZIP Family
Species TF ID Description
XP_008230624.1HD-ZIP family protein
XP_008221655.1HD-ZIP family protein
XP_016651837.1HD-ZIP family protein
XP_008235150.1HD-ZIP family protein
XP_008219409.1HD-ZIP family protein
XP_008230746.1HD-ZIP family protein
XP_008238430.1HD-ZIP family protein
XP_008239846.1HD-ZIP family protein
XP_008221690.1HD-ZIP family protein
XP_008221689.1HD-ZIP family protein
XP_008240912.1HD-ZIP family protein
XP_008221688.1HD-ZIP family protein
XP_016648082.1HD-ZIP family protein
XP_008245761.1HD-ZIP family protein
XP_008245760.1HD-ZIP family protein
XP_016652685.1HD-ZIP family protein
XP_008237058.1HD-ZIP family protein
XP_008232450.1HD-ZIP family protein
XP_008234673.1HD-ZIP family protein
XP_008233081.1HD-ZIP family protein
XP_008241330.1HD-ZIP family protein
XP_008243444.2HD-ZIP family protein
XP_008220424.1HD-ZIP family protein
XP_008241637.1HD-ZIP family protein
XP_008223824.1HD-ZIP family protein
XP_008226425.1HD-ZIP family protein
XP_008228560.1HD-ZIP family protein
XP_008224792.1HD-ZIP family protein
XP_008230079.1HD-ZIP family protein
XP_008232742.1HD-ZIP family protein
XP_008232741.1HD-ZIP family protein
XP_008220092.1HD-ZIP family protein
XP_008240378.1HD-ZIP family protein
XP_008234278.1HD-ZIP family protein
XP_008225592.1HD-ZIP family protein
XP_008228437.1HD-ZIP family protein
XP_008225704.1HD-ZIP family protein
XP_016651445.1HD-ZIP family protein
XP_008238183.1HD-ZIP family protein
XP_016651446.1HD-ZIP family protein
XP_008238184.1HD-ZIP family protein
XP_016649213.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401