PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Pseudotsuga menziesii
HD-ZIP Family
Species TF ID Description
PSME_00038660-RAHD-ZIP family protein
PSME_00033843-RAHD-ZIP family protein
PSME_00017541-RAHD-ZIP family protein
PSME_00000196-RAHD-ZIP family protein
PSME_00004067-RAHD-ZIP family protein
PSME_00027334-RAHD-ZIP family protein
PSME_00032791-RAHD-ZIP family protein
PSME_00053173-RAHD-ZIP family protein
PSME_00032088-RAHD-ZIP family protein
PSME_00039873-RAHD-ZIP family protein
PSME_00045697-RAHD-ZIP family protein
PSME_00028375-RAHD-ZIP family protein
PSME_00022003-RAHD-ZIP family protein
PSME_00000604-RAHD-ZIP family protein
PSME_00014389-RAHD-ZIP family protein
PSME_00006756-RAHD-ZIP family protein
PSME_00044411-RAHD-ZIP family protein
PSME_00045510-RAHD-ZIP family protein
PSME_00014719-RAHD-ZIP family protein
PSME_00028455-RAHD-ZIP family protein
PSME_00000008-RAHD-ZIP family protein
PSME_00044412-RAHD-ZIP family protein
PSME_00054072-RAHD-ZIP family protein
PSME_00014391-RAHD-ZIP family protein
PSME_00051256-RAHD-ZIP family protein
PSME_00049755-RAHD-ZIP family protein
PSME_00011821-RAHD-ZIP family protein
PSME_00028456-RAHD-ZIP family protein
PSME_00018809-RAHD-ZIP family protein
PSME_00036692-RAHD-ZIP family protein
PSME_00016007-RAHD-ZIP family protein
PSME_00036693-RAHD-ZIP family protein
PSME_00011818-RAHD-ZIP family protein
PSME_00028315-RAHD-ZIP family protein
PSME_00036881-RAHD-ZIP family protein
PSME_00018808-RAHD-ZIP family protein
PSME_00017584-RAHD-ZIP family protein
PSME_00016008-RAHD-ZIP family protein
PSME_00027171-RAHD-ZIP family protein
PSME_00037622-RAHD-ZIP family protein
PSME_00038081-RAHD-ZIP family protein
PSME_00016005-RAHD-ZIP family protein
PSME_00024512-RAHD-ZIP family protein
PSME_00024511-RAHD-ZIP family protein
PSME_00008883-RAHD-ZIP family protein
PSME_00013876-RAHD-ZIP family protein
PSME_00049545-RAHD-ZIP family protein
PSME_00038082-RAHD-ZIP family protein
PSME_00056816-RAHD-ZIP family protein
PSME_00021027-RAHD-ZIP family protein
PSME_00048932-RAHD-ZIP family protein
PSME_00044817-RAHD-ZIP family protein
PSME_00013878-RAHD-ZIP family protein
PSME_00049435-RAHD-ZIP family protein
PSME_00040750-RAHD-ZIP family protein
PSME_00013877-RAHD-ZIP family protein
PSME_00038042-RAHD-ZIP family protein
PSME_00009599-RAHD-ZIP family protein
PSME_00032552-RAHD-ZIP family protein
PSME_00019435-RAHD-ZIP family protein
PSME_00031530-RAHD-ZIP family protein
PSME_00001149-RAHD-ZIP family protein
PSME_00033718-RAHD-ZIP family protein
PSME_00017677-RAHD-ZIP family protein
PSME_00019067-RAHD-ZIP family protein
PSME_00034651-RAHD-ZIP family protein
PSME_00028622-RAHD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401