PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Previous version: v3.0 v4.0
Petunia inflata
Species TF ID Description
Peinf101Scf00013g13014.1MIKC_MADS family protein
Peinf101Scf00041g04011.1MIKC_MADS family protein
Peinf101Scf00052g03007.1MIKC_MADS family protein
Peinf101Scf00073g18019.1MIKC_MADS family protein
Peinf101Scf00175g12011.1MIKC_MADS family protein
Peinf101Scf00197g27013.1MIKC_MADS family protein
Peinf101Scf00239g03011.1MIKC_MADS family protein
Peinf101Scf00304g15004.1MIKC_MADS family protein
Peinf101Scf00330g08001.1MIKC_MADS family protein
Peinf101Scf00359g02012.1MIKC_MADS family protein
Peinf101Scf00359g02013.1MIKC_MADS family protein
Peinf101Scf00395g04032.1MIKC_MADS family protein
Peinf101Scf00434g07017.1MIKC_MADS family protein
Peinf101Scf00468g03017.1MIKC_MADS family protein
Peinf101Scf00500g03031.1MIKC_MADS family protein
Peinf101Scf00665g21018.1MIKC_MADS family protein
Peinf101Scf00665g22050.1MIKC_MADS family protein
Peinf101Scf00791g02028.1MIKC_MADS family protein
Peinf101Scf00889g04017.1MIKC_MADS family protein
Peinf101Scf00959g01012.1MIKC_MADS family protein
Peinf101Scf01117g10019.1MIKC_MADS family protein
Peinf101Scf01166g07043.1MIKC_MADS family protein
Peinf101Scf01278g05026.1MIKC_MADS family protein
Peinf101Scf01278g05031.1MIKC_MADS family protein
Peinf101Scf01281g01001.1MIKC_MADS family protein
Peinf101Scf01329g05013.1MIKC_MADS family protein
Peinf101Scf01556g01036.1MIKC_MADS family protein
Peinf101Scf01556g01045.1MIKC_MADS family protein
Peinf101Scf01580g00020.1MIKC_MADS family protein
Peinf101Scf02008g05051.1MIKC_MADS family protein
Peinf101Scf02701g01019.1MIKC_MADS family protein
Peinf101Scf03145g00008.1MIKC_MADS family protein
Peinf101Scf03556g00038.1MIKC_MADS family protein
Peinf101Scf03855g00041.1MIKC_MADS family protein
Peinf101Scf05410g00028.1MIKC_MADS family protein
MIKC_MADS (MIKC-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513