PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Petunia inflata
HD-ZIP Family
Species TF ID Description
Peinf101Scf07353g00026.1HD-ZIP family protein
Peinf101Scf00077g05011.1HD-ZIP family protein
Peinf101Scf02395g01020.1HD-ZIP family protein
Peinf101Scf06431g00032.1HD-ZIP family protein
Peinf101Scf02160g05037.1HD-ZIP family protein
Peinf101Scf01204g00038.1HD-ZIP family protein
Peinf101Scf00702g11003.1HD-ZIP family protein
Peinf101Scf00974g17007.1HD-ZIP family protein
Peinf101Scf01241g15008.1HD-ZIP family protein
Peinf101Scf00231g13016.1HD-ZIP family protein
Peinf101Scf00152g01009.1HD-ZIP family protein
Peinf101Scf00032g13016.1HD-ZIP family protein
Peinf101Scf00792g02019.1HD-ZIP family protein
Peinf101Scf00094g07015.1HD-ZIP family protein
Peinf101Scf04293g00005.1HD-ZIP family protein
Peinf101Scf02232g00005.1HD-ZIP family protein
Peinf101Scf00578g03013.1HD-ZIP family protein
Peinf101Scf00506g20013.1HD-ZIP family protein
Peinf101Scf00606g08019.1HD-ZIP family protein
Peinf101Scf07361g00035.1HD-ZIP family protein
Peinf101Scf01862g00018.1HD-ZIP family protein
Peinf101Scf00851g02013.1HD-ZIP family protein
Peinf101Scf01858g00011.1HD-ZIP family protein
Peinf101Scf02288g00009.1HD-ZIP family protein
Peinf101Scf00930g03013.1HD-ZIP family protein
Peinf101Scf00345g05019.1HD-ZIP family protein
Peinf101Scf00736g15008.1HD-ZIP family protein
Peinf101Scf00047g01010.1HD-ZIP family protein
Peinf101Scf00590g26017.1HD-ZIP family protein
Peinf101Scf00967g03002.1HD-ZIP family protein
Peinf101Scf01482g15029.1HD-ZIP family protein
Peinf101Scf01077g15028.1HD-ZIP family protein
Peinf101Scf00520g06005.1HD-ZIP family protein
Peinf101Scf00896g02007.1HD-ZIP family protein
Peinf101Scf01533g02007.1HD-ZIP family protein
Peinf101Scf02138g03014.1HD-ZIP family protein
Peinf101Scf00140g36005.1HD-ZIP family protein
Peinf101Scf02819g00007.1HD-ZIP family protein
Peinf101Scf00175g04023.1HD-ZIP family protein
Peinf101Scf00692g04010.1HD-ZIP family protein
Peinf101Scf00264g08021.1HD-ZIP family protein
Peinf101Scf00204g10013.1HD-ZIP family protein
Peinf101Scf00482g02011.1HD-ZIP family protein
Peinf101Scf01203g01012.1HD-ZIP family protein
Peinf101Scf02312g03028.1HD-ZIP family protein
Peinf101Scf00698g02035.1HD-ZIP family protein
Peinf101Scf05738g00028.1HD-ZIP family protein
Peinf101Scf05269g00031.1HD-ZIP family protein
Peinf101Scf00126g02006.1HD-ZIP family protein
Peinf101Scf01452g13036.1HD-ZIP family protein
Peinf101Scf00698g02036.1HD-ZIP family protein
Peinf101Scf00536g18015.1HD-ZIP family protein
Peinf101Scf02234g00026.1HD-ZIP family protein
Peinf101Scf01318g08011.1HD-ZIP family protein
Peinf101Scf00293g04013.1HD-ZIP family protein
Peinf101Scf01057g01003.1HD-ZIP family protein
Peinf101Scf01945g01005.1HD-ZIP family protein
Peinf101Ctg13741889g00003.1HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401