PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v1.0, v2.0, v3.0
Phyllostachys heterocycla
HD-ZIP Family
Species TF ID Description
PH01000104G1190HD-ZIP family protein
PH01000569G0270HD-ZIP family protein
PH01005345G0020HD-ZIP family protein
PH01000038G2120HD-ZIP family protein
PH01001550G0050HD-ZIP family protein
PH01000129G1060HD-ZIP family protein
PH01004993G0070HD-ZIP family protein
PH01000188G0440HD-ZIP family protein
PH01000950G0510HD-ZIP family protein
PH01000113G0550HD-ZIP family protein
PH01000219G0690HD-ZIP family protein
PH01000841G0210HD-ZIP family protein
PH01001036G0340HD-ZIP family protein
PH01000007G1150HD-ZIP family protein
PH01002691G0230HD-ZIP family protein
PH01000171G1110HD-ZIP family protein
PH01000193G1220HD-ZIP family protein
PH01002645G0080HD-ZIP family protein
PH01000434G0400HD-ZIP family protein
PH01000407G0480HD-ZIP family protein
PH01000060G1850HD-ZIP family protein
PH01004339G0170HD-ZIP family protein
PH01000496G0570HD-ZIP family protein
PH01001885G0240HD-ZIP family protein
PH01000042G1220HD-ZIP family protein
PH01003417G0160HD-ZIP family protein
PH01000922G0150HD-ZIP family protein
PH01004633G0110HD-ZIP family protein
PH01000670G0190HD-ZIP family protein
PH01000718G0250HD-ZIP family protein
PH01000718G0100HD-ZIP family protein
PH01002645G0100HD-ZIP family protein
PH01000001G0190HD-ZIP family protein
PH01000420G0650HD-ZIP family protein
PH01001350G0200HD-ZIP family protein
PH01002523G0060HD-ZIP family protein
PH01000336G0690HD-ZIP family protein
PH01001914G0110HD-ZIP family protein
PH01000183G0940HD-ZIP family protein
PH01000039G0640HD-ZIP family protein
PH01001892G0010HD-ZIP family protein
PH01000996G0010HD-ZIP family protein
PH01000305G0590HD-ZIP family protein
PH01002498G0270HD-ZIP family protein
PH01000017G2520HD-ZIP family protein
PH01000517G0290HD-ZIP family protein
PH01000014G2500HD-ZIP family protein
PH01000928G0560HD-ZIP family protein
PH01000558G0420HD-ZIP family protein
PH01001857G0080HD-ZIP family protein
PH01001046G0030HD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401